FXR

FXR; NR1H4

FXR

Related Products

Farnesoid X receptor (FXR) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. FXR regulates the expression of various genes by binding to DNA either as a monomer or a heterodimer with the common partner for NRs, retinoid x receptor (RXR), to FXR response elements. Two known FXR genes exist, the FXRα and FXRβ.

FXR is mainly expressed in liver and small intestine, where it plays an important role in bile acid, lipid, and glucose metabolism. FXR affects several metabolic pathways through its specific target genes, regulating bile acid (BA) synthesis and homeostasis, glucose and lipid metabolism, also exhibiting a crucial role in intestinal bacterial growth and liver regeneration.

FXR Related Products (83)
Antibodies (2)

By Effects:	Inhibitors (7) Agonists (44) Antagonists (19) Activators (10) Modulators (3)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-13771S1

Ursodeoxycholic acid-¹³C	Antagonist
Ursodeoxycholic acid-¹³C is the ¹³C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].

HY-109083A

Cilofexor tromethamine	Agonist
Cilofexor tromethamine (GS-9674 tromethamine) is a nonsteroidal farnesene oxide receptor agonist with activity in improving markers of cholestasis and liver injury. Cilofexor tromethamine was shown to be well tolerated in patients without cirrhosis and resulted in significant improvements in liver biochemical parameters and cholestatic markers. Cilofexor tromethamine offers a potential inhibitory option for the management of primary sclerosing cholangitis.

HY-N3891

Fargesone A	Agonist
Fargesone A is a potent and selective FXR agonist. Fargesone A shows anti-inflammatory activity.

HY-163466

FXR agonist 7	Inhibitor
FXR agonist 7 (compound 33) is a potent agonist of FXR, with EC₅₀ of 0.1 nM. FXR agonist 7 shows high intestinal distribution, good anti-inflammatory activity.

HY-76847A

Chenodeoxycholic acid sodium	Antagonist
Chenodeoxycholic acid sodium is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-50108A

(E)-GW 4064	Agonist
(E)-GW 4064 is a FXR agonist.

HY-122338

Fexarine	Agonist
Fexarine is a potent, non-steroidal and selective agonist of farnesoid X receptor (EC₅₀: 38 nM). Fexarine can be used for the research of diseases linked to cholesterol, bile acids.

HY-168516

FXR/CES2 modulator 1	Inhibitor
FXR/CES2 modulator 1 (compound LE-77) is a doul modulator that activates FXR and inhibits CES2. FXR/CES2 modulator 1 effectively mitigates the intestinal toxicity of irinotecan.

HY-160929

Linafexor	Agonist
Linafexor (CS-0159) is an agonist for farnesoid X receptor (FXR).

HY-169192

BAR-2227	Agonist
BAR-2227 (compound 3a) is a FXR agonist and LIFR inhibitor. BAR-2227 can be used to study liver fibrosis and inflammation.

HY-N3209

Nelumol A	Agonist
Nelumol A is a farnesoid X receptor (FXR) agonist.

HY-121153

Altenusin	Agonist
Altenusin shows markedly DPPH radical scavenging activities.

HY-135400S

Glyco-obeticholic acid-d₅	Agonist
Glyco-obeticholic acid-d₅ is the deuterium labeled Glyco-Obeticholic acid. Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist[1].

HY-133890

Tauro-α-muricholic acid	Activator
Tauro-alpha-muricholic acid (T-alpha-MCA) is a bile acid that belongs to a class of compounds that are synthesized in the liver and play an important role in the digestive process. Tauro-α-muricholic acid activates Farni X receptors (FXR) which are involved in the regulation of bile acid synthesis, metabolism and transport. Tauro-alpha-muricholic acid can be used in the study of metabolic syndrome and cardiovascular disease.

HY-159845

Lecufexor	Agonist
Lecufexor is a farnesoid X receptor (FXR) agonist.

HY-135399S

Tauro-obeticholic acid-d₅ sodium	Agonist
Tauro-obeticholic acid-d₅ sodium is deuterium labeled Tauro-obeticholic acid. Tauro-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist.

HY-110066R

(Z)-Guggulsterone (Standard)	Antagonist
(Z)-Guggulsterone (Standard) is the analytical standard of (Z)-Guggulsterone. This product is intended for research and analytical applications. (Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection.

HY-76847S1

Chenodeoxycholic Acid-d₉	Activator
Chenodeoxycholic Acid-d₉ is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-151959

FXR agonist 4	Inhibitor
FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC₅₀ value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD).

HY-163071

V023-9340	Antagonist
V023-9340 is a potent FXR inhibitor with IC₅₀ of 4.27 μM that can be used in NASH (nonalcoholic steatohepatitis) research.

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FXR

FXR

FXR Related Products (83)

Antibodies (2)

FXR Related Products (83):