EML4 - EMAP like 4 Gene

Homo sapiens

Also known as C2orf2; ELP120; EMAP-4; EMAPL4; ROPP120

Gene ID: 27436 | Gene type: protein coding

About EML4

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:42,169,353-42,332,548 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues, 9 paralogues and is associated with 96 phenotypes. Ubiquitous expression in appendix (RPKM 24.1), duodenum (RPKM 22.4) and 25 other tissues.

Summary

This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung Cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]

EML4 Products(3)

mRNA	Protein	Name
NM_001145076.3	NP_001138548.2	echinoderm microtubule-associated protein-like 4 isoform b
NM_001410776.1	NP_001397705.1	echinoderm microtubule-associated protein-like 4 isoform c
NM_019063.5	NP_061936.3	echinoderm microtubule-associated protein-like 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	31409757	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	31409757	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25789526	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	25789526	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	25789526	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16890222	GOA
located in microtubule	IDA IDA: Inferred from direct assay	16890222	GOA
located in microtubule organizing center	IDA IDA: Inferred from direct assay	16890222	GOA
located in midbody	IDA IDA: Inferred from direct assay	25789526	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	16890222	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EML4 Protein Structure

HELP

WD40

0
200
400
600
800
981 a.a.

Protein Preferred Names

Protein Names

echinoderm microtubule-associated protein-like 4

echinoderm microtubule associated protein like 4

Related Diseases

Diseases

Alias

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Signet Ring Lung Adenocarcinoma

Nephroma

Benign Nephroma

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Anaplastic Large Cell Lymphoma

Alcl	Cd30 Positive Anaplastic Large Cell Lymphoma
Ki-1 Positive Anaplastic Large Cell Lymphoma	Primary Systemic Alcl
Sacl	Ki-1+ Anaplastic Large Cell Lymphoma

Lung Combined Large Cell Neuroendocrine Carcinoma

Combined Large Cell Neuroendocrine Carcinoma Of Lung	Pulmonary Combined Large Cell Neuroendocrine Carcinoma
Combined Large Cell Lung Neuroendocrine Carcinoma

Lung Non-Squamous Non-Small Cell Carcinoma

Non- Squamous Nsclc

Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor	Mesenchymal Tumor
Mesenchymal Tumors

Congenital Fibrosarcoma

Infantile Fibrosarcoma

Childhood Fibrosarcoma

Pediatric Fibrosarcoma

Epithelioid Inflammatory Myofibroblastic Sarcoma

Pulmonary Adenocarcinoma In Situ

Bronchioalveolar Carcinoma

Occipital Lobe Neoplasm

Neoplasm Of Occipital Lobe	Malignant Neoplasm Of Occipital Lobe
Tumor Of Occipital Lobe

Lung Sarcomatoid Carcinoma

Sarcomatoid Carcinoma Of The Lung

Pulmonary Sarcomatoid Carcinoma

Congenital Mesoblastic Nephroma

Mesoblastic Nephroma

Nephroma, Mesoblastic

Lung Carcinoma In Situ

Pleomorphic Carcinoma

Thyroid Gland Hurthle Cell Carcinoma

Oncocytic Carcinoma Of The Thyroid

Thyroid Cancer, Hurthle Cell

Lung Large Cell Carcinoma

Large Cell Carcinoma Of Lung	Large Cell Lung Carcinoma
Large Cell Lung Cancer

Large Cell Carcinoma

Carcinoma, Large Cell

Carcinoma Large Cell

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Gastrointestinal Stromal Tumor

GIST	Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Sarcoma	Gastrointestinal Stromal Tumor, Familial
Gant	Gastrointestinal Stromal Tumour
Stromal Tumor Of Gastrointestinal Tract	Stromal Tumour Of Gastrointestinal Tract
Gastrointestinal Stromal Neoplasm	Paraganglioma And Gastric Stromal Sarcoma
Plexosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12215	Lorlatinib		99.92%	Yes
HY-12215R	Lorlatinib (Standard)		/	Unkown

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153386	CPD-1224	Inhibitor	99.24%	Unkown
HY-111752	EML4-ALK kinase inhibitor 1	Inhibitor	98.02%	Unkown
HY-112140	JH-VIII-157-02	Inhibitor	99.67%	Unkown
HY-135509	Lorlatinib acetate		/	Unkown
HY-131244	ALK-IN-9	Inhibitor	/	Unkown
HY-143557	Trk-IN-7	Inhibitor	/	Unkown
HY-155227	ALK/EGFR-IN-1		/	Unkown
HY-155227A	ALK/EGFR-IN-2	Inhibitor	/	Unkown
HY-155227B	ALK/EGFR-IN-3	Inhibitor	/	Unkown
HY-161749	PROTAC ALK degrader-1	Degrader	/	Unkown
HY-161750	PROTAC ALK degrader-2	Degrader	/	Unkown
HY-161910	SH-E4A-66	Inhibitor	/	Unkown
HY-163807	22-SLF	Degrader	/	Unkown
HY-164397	XMU-MP-5		/	Unkown
HY-RS04356	EML4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EML4	MGD	MGI:1926048
Felis catus	EML4	VGNC	VGNC:61851
Macaca mulatta	EML4	VGNC	VGNC:72037
Bos taurus	EML4	VGNC	VGNC:28478
Rattus norvegicus	EML4	RGD	RGD:1304690
Canis familiaris	EML4	VGNC	VGNC:40349

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