TTLL6 - tubulin tyrosine ligase like 6 Gene

Homo sapiens

Also known as TTL.6

Gene ID: 284076 | Gene type: protein coding

About TTLL6

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,762,234-48,817,229 (from NCBI)

This gene has 9 transcripts (splice variants), 120 orthologues and 12 paralogues. Biased expression in testis (RPKM 10.4), colon (RPKM 1.9) and 5 other tissues.

Summary

Predicted to enable tubulin binding activity and tubulin-glutamic acid Ligase activity. Predicted to be involved in microtubule Cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within microtubule bundle formation; microtubule severing; and positive regulation of cilium movement. Located in ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]

TTLL6 Products(3)

mRNA	Protein	Name
NM_001130918.3	NP_001124390.1	tubulin polyglutamylase TTLL6 isoform 1
NM_001366314.2	NP_001353243.1	tubulin polyglutamylase TTLL6 isoform 3
NM_173623.4	NP_775894.2	tubulin polyglutamylase TTLL6 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22246503	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	22246503	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTLL6 Protein Structure

TTL

0
200
400
600
800
891 a.a.

Protein Preferred Names

Protein Names

tubulin polyglutamylase TTLL6

protein polyglutamylase TTLL6

Related Diseases

Diseases

Alias

Joubert Syndrome 33

JBTS33

Joubert Syndrome, Type 33

Joubert Syndrome 15

JBTS15

Joubert Syndrome, Type 15

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15233	TTLL6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TTLL6	VGNC	VGNC:36494
Rattus norvegicus	TTLL6	RGD	RGD:1311922
Canis familiaris	TTLL6	VGNC	VGNC:47977
Felis catus	TTLL6	VGNC	VGNC:66688
Macaca mulatta	TTLL6	VGNC	VGNC:79632
Mus musculus	TTLL6	MGD	MGI:2683461

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