HSF4 - heat shock transcription factor 4 Gene

Homo sapiens

Also known as CTM; CTRCT5

Gene ID: 3299 | Gene type: protein coding

About HSF4

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,163,761-67,169,941 (from NCBI)

This gene has 29 transcripts (splice variants), 217 orthologues, 9 paralogues and is associated with 5 phenotypes. Ubiquitous expression in prostate (RPKM 12.6), skin (RPKM 8.5) and 24 other tissues.

Summary

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]

HSF4 Products(4)

mRNA	Protein	Name
NM_001040667.3	NP_001035757.1	heat shock factor protein 4 isoform b
NM_001374674.1	NP_001361603.1	heat shock factor protein 4 isoform a
NM_001374675.1	NP_001361604.1	heat shock factor protein 4 isoform b
NM_001538.4	NP_001529.2	heat shock factor protein 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8972228	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8972228	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	16581800	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8972228	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	8972228	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSF4 Protein Structure

HSF_DNA-bind

0
100
200
300
400
492 a.a.

Protein Preferred Names

Protein Names

heat shock factor protein 4

HSF 4

Related Diseases

Diseases

Alias

Cataract 5, Multiple Types

CTRCT5	Cataract, Marner Type
Cataract 5 Multiple Types	Cam
Cataract, Lamellar	Cataract Marner Type
Ctm	Cataract, Type 5, Multiple Types

Early-Onset Lamellar Cataract

Cataract 44

CTRCT44	Total Early-Onset Cataract
Cataract 44 And Hypotrichosis	Cataract And Hypotrichosis
Cataract, Type 44

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Anterior Spinal Artery Syndrome

Anterior Spinal Artery Occlusion Syndrome

Posterior Polar Cataract

Cataract, Posterior Polar

Nance-Horan Syndrome

NHS	Cataract-Dental Syndrome
Cataract, X-Linked, With Hutchinsonian Teeth	Mesiodens-Cataract Syndrome
Cataract X-Linked With Hutchinsonian Teeth	Cataract Dental Syndrome
Mesiodens Cataract Syndrome

Senile Cataract

Amblyopia

Lazy Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06411	HSF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HSF4	VGNC	VGNC:67663
Mus musculus	HSF4	MGD	MGI:1347058
Rattus norvegicus	HSF4	RGD	RGD:1310808
Macaca mulatta	HSF4	VGNC	VGNC:73533
Bos taurus	HSF4	VGNC	VGNC:29984

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