2. Gene
  3. TTF1 - transcription termination factor 1 Gene

TTF1 - transcription termination factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TTF-1; TTF-I

Gene ID: 7270 | Gene type: protein coding

About TTF1

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:132,375,548-132,406,840 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 5.3), testis (RPKM 4.8) and 25 other tissues.

Summary

This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]

TTF1 Products(2)

mRNA Protein Name
NM_001205296.2 NP_001192225.1 transcription termination factor 1 isoform 2
NM_007344.4 NP_031370.2 transcription termination factor 1 isoform 1

TTF1 Protein Structure

Myb_DNA-bind_6

Myb_DNA-bind_6: Myb-like DNA-binding domain (621 - 677)

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  • 905 a.a.
Protein Preferred Names Protein Names

transcription termination factor 1

transcription termination factor, RNA polymerase I

Related Diseases

Diseases Alias
Cervical Carcinosarcoma

Cervical Malignant Mixed Mesodermal Mullerian Tumor

Cervical Malignant Mixed Mullerian Tumor

Cervical Mixed Epithelial And Mesenchymal Neoplasm
Blastoma

Embryoma
Chordoid Glioma

Chordoid Glioma Of The Third Ventricle
Smarca4-Deficient Sarcoma Of Thorax

Smarca4-Dts

Smarca4-Deficient Thoracic Sarcoma
Pulmonary Blastoma

Blastoma Of Lung

Pneumoblastoma
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15222 TTF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TTF1 RGD RGD:1565673
Bos taurus TTF1 VGNC VGNC:36483
Canis familiaris TTF1 VGNC VGNC:47967
Macaca mulatta TTF1 VGNC VGNC:78669
Mus musculus TTF1 MGD MGI:105044
Felis catus TTF1 VGNC VGNC:103003