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  5. Pulvomycin

Pulvomycin (Antibiotic 1063Z) is an antibiotic with protein biosynthesis inhibitory activity. Pulvomycin is able to block protein biosynthesis in Bacillus brevis grown in cells. Pulvomycin is highly sensitive to poly(Phe) synthesis in cell-free systems. Pulvomycin does not affect the transfer of phenylalanine to tRNA. Studies have shown that the target of Pulvomycin is the elongation of the polypeptide chain. Pulvomycin can also prevent the formation of a ternary complex between the elongation factor Tu, GTP and aminoacyl-tRNA.

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Pulvomycin Chemical Structure

Pulvomycin Chemical Structure

CAS No. : 11006-66-9

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Pulvomycin Related Antibodies

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Description

Pulvomycin (Antibiotic 1063Z) is an antibiotic with protein biosynthesis inhibitory activity. Pulvomycin is able to block protein biosynthesis in Bacillus brevis grown in cells. Pulvomycin is highly sensitive to poly(Phe) synthesis in cell-free systems. Pulvomycin does not affect the transfer of phenylalanine to tRNA. Studies have shown that the target of Pulvomycin is the elongation of the polypeptide chain. Pulvomycin can also prevent the formation of a ternary complex between the elongation factor Tu, GTP and aminoacyl-tRNA[1].

Molecular Weight

839.02

Formula

C47H66O13
CAS No.
SMILES

O=C(C/C=C(C)/[C@H](O)/C=C(C)/C=C/C=C1\C)O[C@H]([C@@H](C)[C@H](O)[C@H](C)C(/C=C/C=C/C=C/[C@H](O)[C@@H](O[C@H]2[C@@H]([C@H]([C@H]([C@@H](C)O2)OC)O)OC)C)=O)C/C=C/C=C/C=C/[C@H](O)C1=O
Structure Classification
Initial Source

Streptoverticillium mobaraense
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pulvomycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pulvomycin11006-66-9Antibiotic 1063ZOthersInhibitorinhibitorinhibit

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