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Results for "

Ach

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Adenosine Receptor (2) Amyloid-β (1) Apoptosis (1) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) Calcium Channel (9) Caspase (1) Cholinesterase (ChE) (7) Complement System (2) Endogenous Metabolite (12) HBV (1) HCV (2) HCV Protease (1) Histamine Receptor (1) Isotope-Labeled Compounds (4) mAChR (23) Melatonin Receptor (1) MMP (1) nAChR (18) Opioid Receptor (1) Parasite (1) Potassium Channel (4) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (11) Infection (5) Inflammation/Immunology (5) Metabolic Disease (8) Neurological Disease (47)

By Targets:

5-HT Receptor (4)

Adenosine Receptor (2)

Amyloid-β (1)

Apoptosis (1)

Autophagy (1)

Bacterial (1)

Biochemical Assay Reagents (1)

Calcium Channel (9)

Caspase (1)

Cholinesterase (ChE) (7)

Complement System (2)

Endogenous Metabolite (12)

HBV (1)

HCV (2)

HCV Protease (1)

Histamine Receptor (1)

Isotope-Labeled Compounds (4)

mAChR (23)

Melatonin Receptor (1)

MMP (1)

nAChR (18)

Opioid Receptor (1)

Parasite (1)

Potassium Channel (4)

Prolyl Endopeptidase (PREP) (2)

Prostaglandin Receptor (1)

By Research Areas:

Cancer (9)

Cardiovascular Disease (11)

Infection (5)

Inflammation/Immunology (5)

Metabolic Disease (8)

Neurological Disease (47)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138626

ACH-000143	Melatonin Receptor	Metabolic Disease
ACH-000143 is a potent and orally active melatonin receptor agonist, with EC₅₀ values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively .

HY-117930

Danicopan 3 Publications Verification Ach-4471	Complement System	Inflammation/Immunology
Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with K_d value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .

HY-101086

Acetylcholine iodide 10+ Cited Publications Ach iodide	Endogenous Metabolite	Neurological Disease Cancer
Acetylcholine iodide (ACh iodide) is a common neurotransmitter found in the central and peripheral nerve system .

HY-B0282

Acetylcholine chloride 10+ Cited Publications Ach chloride	nAChR Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

HY-B0282S1

Acetylcholine-d9 chloride Ach-d₉(chloride)	nAChR Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Acetylcholine-d₉ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-B0282S

Acetylcholine-d4 chloride Ach-d₄ (chloride)	nAChR Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Acetylcholine-d₄ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-123451

ACH-702	Bacterial	Infection
ACH-702 is a potent anti-tubercular agent. ACH-702 also shows broad-spectrum antibacterial activity .

HY-19512

ACH-806 GS9132	HCV Protease HCV	Infection
ACH-806 is an NS4A antagonist which can inhibit Hepatitis C Virus (HCV) replication with an EC₅₀ of 14 nM.

HY-W003576

ACHE-IN-38 hydrochloride	Others	Neurological Disease
ACHE-IN-38 hydrochloride (Compound 13b) inhibits the metabolic breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase (AChE) and hence alleviates memory deficits in patients with Alzheimer’s Disease by potentiating cholinergic transmission .

HY-W415004

ACHE-IN-38	Others	Neurological Disease
ACHE-IN-38 (Compound mol-8) inhibits the metabolic breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase (AChE) and hence alleviates memory deficits in patients with Alzheimer’s Disease by potentiating cholinergic transmission .

HY-139588

Vemircopan ALXN2050; Ach 0145228; Ach-5228	Complement System	Metabolic Disease Inflammation/Immunology
Vemircopan (ALXN2050) is an orally active complement factor D inhibitor. Vemircopan is promising for research of paroxysmal nocturnal hemoglobinuria .

HY-13401

Sovaprevir Ach 0141625	Others	Others
Sovaprevir is an active compound.

HY-B0282A

Acetylcholine bromide 10+ Cited Publications Ach bromide	Biochemical Assay Reagents	Others Cancer
Acetylcholine bromide is an organic choline salt compound commonly used in neurophysiology and pharmacology experiments. It plays an important role in the nervous system, acting as a neurotransmitter that transmits signals and regulates many important physiological functions. Due to its special biological activity, Acetylcholine bromide is widely used in the study of neurotransmitters, nerve damage and muscle movement.

HY-B0282AS1

Acetylcholine-d4 bromide Ach-d₄ bromide	nAChR Calcium Channel Endogenous Metabolite Isotope-Labeled Compounds	Others
Acetylcholine-d₄ (bromide) is the deuterium labeled Acetylcholine bromide[1].

HY-B0282AS

Acetylcholine-d9 bromide Ach-d₉ bromide	nAChR Calcium Channel Endogenous Metabolite Isotope-Labeled Compounds	Others
Acetylcholine-d₉ (bromide) is the deuterium labeled Acetylcholine bromide .

HY-B0282AS2

Acetylcholine-d13 bromide Ach-d₁₃ bromide	nAChR Calcium Channel Endogenous Metabolite Isotope-Labeled Compounds	Others
Acetylcholine-d₁₃ (bromide) is the deuterium labeled Acetylcholine bromide[1].

HY-B0282AS3

Acetylcholine-d16 bromide Ach-d₁₆ bromide	nAChR Calcium Channel Endogenous Metabolite Isotope-Labeled Compounds	Others
Acetylcholine-d₁₆ (bromide) is the deuterium labeled Acetylcholine bromide[1].

HY-P2860

Acetylcholinesterase, Fly head AchE; EC 3.1.1.7	Cholinesterase (ChE)	Neurological Disease
Acetylcholinesterase, Fly head (ACHE; EC 3.1.1.7) is a cholinergic enzyme mainly found in neuromuscular junctions and cholinergic type chemical synapses used in biochemical research. Acetylcholinesterase, Fly head catalyzes the breakdown or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetate and choline. Acetylcholinesterase, Fly head's main role is to terminate neuronal transmission and signaling between synapses to prevent ACh spread and activation of nearby receptors .

HY-B1304A

(+)-Sparteine sulfate pentahydrate 1 Publications Verification (+)-Lupinidine sulfate pentahydrate	nAChR	Neurological Disease
(+)-sparteine (sulfate pentahydrate) is a ganglionic blocking agent. (+)-Sparteine competitively blocks *nicotinic ACh* receptor** in the neurons .

HY-107562

JNJ 10181457 dihydrochloride	Histamine Receptor	Neurological Disease
JNJ-10181457 is a neutral, potent, brain-penetrant and selective non-imidazole H₃ antagonist which increases NE and ACh concentrations in rat frontal cortex. JNJ-10181457 can be used for neurological research .

HY-103182A

PSB-1115 potassium salt	Adenosine Receptor	Others
PSB-1115 potassium salt is a selective A2B Adenosine Receptor antagonist. PSB-1115 potassium salt inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh) .

HY-18138

PF-03382792	5-HT Receptor	Neurological Disease
PF-03382792 is a potent 5-HT₄ partial agonist with a K_i of 2.7 nM and an EC₅₀ of 0.9 nM for 5-HT_4d. PF-03382792 can penetrate the brain. PF-03382792 produces moderate increases in cortical Ach in the rat prefrontal cortex .

HY-B1205

Atropine Maximum Cited Publications 16 Publications Verification Tropine tropate; DL-Hyoscyamine	mAChR Endogenous Metabolite	Cardiovascular Disease Neurological Disease
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .

HY-B0394

Atropine sulfate monohydrate Maximum Cited Publications 16 Publications Verification Tropine tropate sulfate monohydrate; DL-Hyoscyamine sulfate monohydrate	mAChR	Cardiovascular Disease Neurological Disease
Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

HY-B1205A

Atropine sulfate Maximum Cited Publications 16 Publications Verification Tropine tropate sulfate; DL-Hyoscyamine sulfate; Sulfatropinol	mAChR	Cardiovascular Disease Neurological Disease
Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-B1205B

Atropine hydrobromide Tropine tropate hydrobromide; DL-Hyoscyamine hydrobromide	mAChR	Cardiovascular Disease Neurological Disease
Atropine (Tropine tropate) hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia .

HY-12439

ML380 1 Publications Verification	mAChR	Neurological Disease
ML380 is a potent, subtype-selective, and brain-penetrant positive allosteric modulator (PAM) of M5 mAChR, with EC₅₀s of 190 and 610 nM for human and rat M5, respectively. ML380 exhibits moderate selectivity versus the M1 and M3 mAChR subtypes. ML380 could increase the affinity of ACh for the M5 mAChR .

HY-B1205AR

Atropine sulfate (Standard)	mAChR	Cardiovascular Disease Neurological Disease
Atropine (sulfate) (Standard) is the analytical standard of Atropine (sulfate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-B0394R

Atropine sulfate monohydrate (Standard)	mAChR	Cardiovascular Disease Neurological Disease
Atropine (sulfate monohydrate) (Standard) is the analytical standard of Atropine (sulfate monohydrate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

HY-B2152

Hemicholinium 3 Hemicholinium dibromide	Cholinesterase (ChE)	Neurological Disease
Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a K_i value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh) . Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [ ³H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively .

HY-120184

VU0467485 AZ13713945	mAChR	Neurological Disease
VU0467485 (AZ13713945) is a potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator (PAM). VU0467485 (AZ13713945) potentiates activity of ACh at M4 with EC₅₀s of 26.6 nM and 78.8 nM at rat and human M4 receptors, respectively. VU0467485 (AZ13713945) shows selectivity for M4 over human and rat M1/2/3/5. VU0467485 (AZ13713945) displays moderate to high CNS penetration. VU0467485 (AZ13713945) has antipsychotic-like activity .

HY-N7247

Thiochrome	mAChR	Metabolic Disease
Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors .

HY-19411

SSR180711 hydrochloride	nAChR	Neurological Disease
SSR180711 hydrochloride is an orally active, selective and reversible α7 acetylcholine nicotinic receptor (n-AChRs) partial agonist. SSR180711 hydrochloride can act on rat α7 n-AChR (K_i=22 nM; IC₅₀=30 nM) and human α7 n-AChR (K_i=14 nM; IC₅₀=18 nM). SSR180711 hydrochloride increases glutamatergic neurotransmission, ACh release and long-term potentiation (LTP) in the hippocampus .

HY-16658C

Z-VA-DL-D-FMK Z-VA-DL-D(OH)-FMK	Caspase	Infection
Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) is an inhibitor for caspase . Z-VA-DL-D-FMK binds irreversibly to caspases, increases the sensitivity of TNF-α, and activates HIV replication in infected T cell ACH-2 .

HY-N7247R

Thiochrome (Standard)	mAChR	Metabolic Disease
Thiochrome (Standard) is the analytical standard of Thiochrome. This product is intended for research and analytical applications. Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors .

HY-N8376

Fustin (±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone	Amyloid-β mAChR Cholinesterase (ChE)	Neurological Disease
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research .

HY-144801A

DDO-02005	Potassium Channel	Cardiovascular Disease
DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC₅₀ value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl₂-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine .

HY-W008350

(+)-Sparteine 1 Publications Verification PAchycarpine	nAChR	Neurological Disease
(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks *nicotinic ACh* receptor** in the neurons.

HY-144801

DDO-02005 free base	Potassium Channel	Cardiovascular Disease
DDO-02005 (free base) is a potent Kv1.5 potassium channel inhibitor with an IC₅₀ value of 0.72 μM. DDO-02005 (free base) has good anti-atrial fibrillation (AF) effect in CaCl₂-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine .

HY-145780

Cytidine 5′-diphosphoethanolamine	Cholinesterase (ChE)	Others
Cytidine 5′-diphosphoethanolamine is an intermediate compound in the synthesis of phosphatidylethanolamine. Cytidine 5′-diphosphoethanolamine is a stimulant of Ach synthesis .

HY-16678

Helioxanthin	HBV HCV	Infection
Helioxanthin (ACH126447) has in vitro antiviral activity with an EC₅₀ of 1 μM against HBV and is also active against flaviviruses.

HY-129826

J-104129	mAChR	Others
J-104129 is a selective and orally active muscarinic M3 receptor antagonist (K_i = 4.2 nM). J-104129 is effective in promoting bronchodilation .

HY-111161

GSK575594A	nAChR Parasite	Infection
GSK575594A is a modulator of the nicotinic acetylcholine receptor (nAChR) in Ascaris suum. GSK575594A enhances muscle contractions induced by acetylcholine (ACh) by binding to the allosteric binding site between subunits within the transmembrane domain of nAChR. At a concentration of 3 μM, GSK575594A significantly increased the contraction induced by ACh in Ascaris suum (E_max increased from 1.19 g to 1.51 g). GSK575594A may be used in research within the field of antiparasitic studies .

HY-B1178A

R-(+)-Cotinine (+)-Cotinine; (R)-Cotinine; (R)-NIH-10498	nAChR	Neurological Disease
R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs .

HY-100795

Pirmenol (±)-Pirmenol; CI-845 free base	mAChR Potassium Channel	Cardiovascular Disease
Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits *I_K.ACh* (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation .

HY-103182

PSB-1115	Adenosine Receptor	Others
PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh) .

HY-100795A

Pirmenol hydrochloride (±)-Pirmenol hydrochloride; CI-845	mAChR Potassium Channel	Cardiovascular Disease
Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits *I_K.ACh* (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation .

HY-P2626

[D-Ala2]-Met-Enkephalin	Opioid Receptor	Neurological Disease
[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release .

HY-128783

VU0090157	mAChR	Neurological Disease
VU0090157 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR). VU0090157 increases the affinity of ACh by binding to the allosteric site. VU0090157 can be used in the study of schizophrenia and Alzheimer's disease .

HY-112209

VU0467154 1 Publications Verification	mAChR	Neurological Disease
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR), potentiating the response to ACh with pEC₅₀s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively.

Cat. No.	Product Name	Type

HY-B0282A

Acetylcholine bromide

10+ Cited Publications

Ach bromide

Biochemical Assay Reagents

Acetylcholine bromide is an organic choline salt compound commonly used in neurophysiology and pharmacology experiments. It plays an important role in the nervous system, acting as a neurotransmitter that transmits signals and regulates many important physiological functions. Due to its special biological activity, Acetylcholine bromide is widely used in the study of neurotransmitters, nerve damage and muscle movement.

Cat. No.	Product Name	Target	Research Area

HY-P2626

[D-Ala2]-Met-Enkephalin	Opioid Receptor	Neurological Disease
[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-101086

Acetylcholine iodide 10+ Cited Publications Ach iodide	Structural Classification Natural Products Animals Source classification	Endogenous Metabolite
Acetylcholine iodide (ACh iodide) is a common neurotransmitter found in the central and peripheral nerve system .

HY-B0282

Acetylcholine chloride 10+ Cited Publications Ach chloride	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	nAChR Calcium Channel Endogenous Metabolite
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

HY-B0282A

Acetylcholine bromide 10+ Cited Publications Ach bromide	Classification of Application Fields Disease Research Fields Cancer	Biochemical Assay Reagents
Acetylcholine bromide is an organic choline salt compound commonly used in neurophysiology and pharmacology experiments. It plays an important role in the nervous system, acting as a neurotransmitter that transmits signals and regulates many important physiological functions. Due to its special biological activity, Acetylcholine bromide is widely used in the study of neurotransmitters, nerve damage and muscle movement.

HY-B1304A

(+)-Sparteine sulfate pentahydrate 1 Publications Verification (+)-Lupinidine sulfate pentahydrate	Alkaloids Piperidine Alkaloids other families Source classification Plants	nAChR
(+)-sparteine (sulfate pentahydrate) is a ganglionic blocking agent. (+)-Sparteine competitively blocks *nicotinic ACh* receptor** in the neurons .

HY-B1205

Atropine Maximum Cited Publications 16 Publications Verification Tropine tropate; DL-Hyoscyamine	Alkaloids Structural Classification Microorganisms Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants Endogenous metabolite	mAChR Endogenous Metabolite
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .

HY-B0394

Atropine sulfate monohydrate Maximum Cited Publications 16 Publications Verification Tropine tropate sulfate monohydrate; DL-Hyoscyamine sulfate monohydrate	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR
Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

HY-B1205A

Atropine sulfate Maximum Cited Publications 16 Publications Verification Tropine tropate sulfate; DL-Hyoscyamine sulfate; Sulfatropinol	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR
Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-N8376

Fustin (±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone	Flavanonols Flavonoids Source classification Plants Rhus glabra L. Anacardiaceae	Amyloid-β mAChR Cholinesterase (ChE)
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research .

HY-B1205AR

Atropine sulfate (Standard)	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR
Atropine (sulfate) (Standard) is the analytical standard of Atropine (sulfate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-B0394R

Atropine sulfate monohydrate (Standard)	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR
Atropine (sulfate monohydrate) (Standard) is the analytical standard of Atropine (sulfate monohydrate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

HY-W008350

(+)-Sparteine 1 Publications Verification PAchycarpine	Alkaloids Piperidine Alkaloids Structural Classification other families Source classification Plants	nAChR
(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks *nicotinic ACh* receptor** in the neurons.

HY-N7038

Phytohemagglutinin 4 Publications Verification PHA-M	Natural Products Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Plants Disease Research Fields Inflammation/Immunology	Others
Phytohemagglutinin (PHA-M), the major seed lectin of the common bean, Phaseolus vulgaris, accumulates in the parenchyma cells of the cotyledons. Phytohemagglutinin is a T-cell activator. Stimulation of human mononuclear leukocytes by Phytohemagglutinin induces the expression of ChAT mRNA, and potentiated ACh synthesis .

HY-N1064

Xanthoplanine	Alkaloids Structural Classification Monophenols other families Source classification Phenols Plants Isoquinoline Alkaloids	nAChR
Xanthoplanine, isolated from theroot of Xylopia parviflora, fully inhibits the EC₅₀ ACh responses of both alpha7 and alpha4beta2 nACh receptors with estimated IC₅₀ values of 9 μM (alpha7) and 5 μM (alpha4beta2) .

HY-B0282R

Acetylcholine chloride (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	nAChR Calcium Channel Endogenous Metabolite
Acetylcholine (chloride) (Standard) is the analytical standard of Acetylcholine (chloride). This product is intended for research and analytical applications. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

HY-N0801

Polygalacic acid	Triterpenes Terpenoids Source classification Polygalaceae Plants Polygala tenuifolia Willd.	MMP Cholinesterase (ChE)
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex .

HY-B1205R

Atropine (Standard) Tropine tropate (Standard); DL-Hyoscyamine (Standard)	Source classification Atropa belladonna Linn. Solanaceae Plants Endogenous metabolite	mAChR Endogenous Metabolite
Atropine (Standard) is the analytical standard of Atropine. This product is intended for research and analytical applications. Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .

Species:	Human (9) Mouse (2)
Tag:	His (11) Avi (8) B2M (1) Fc (1)
Source:	HEK293 (10) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72196

	FGFR-3 Protein, Human (His-B2M) Ach; CD 333; CD333; CD333 antigen; CEK 2; CEK2; FGFR 3; FGFR-3; FGFR3; FGFR3_HUMAN; Fibroblast growth factor receptor 3 Achondroplasia thanatophoric dwarfism; ; Fibroblast growth factor receptor 3; Heparin binding growth factor receptor; HSFGFR3EX; Hydroxyaryl protein kinase; JTK 4; JTK4; MFR 3; SAM 3; Tyrosine kinase JTK 4; Tyrosine kinase JTK4; Z FGFR 3	Human	E. coli
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (His-B2M) is the recombinant human-derived FGFR-3 protein, expressed by E. coli , with N-6*His, N-B2M labeled tag.

HY-P77662

	FGFR-3 alpha (IIIb) Protein, Mouse (HEK293, His) Ach; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Mouse	HEK293
	FGFR-3 alpha (IIIb) Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-3 alpha, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-3 alpha (IIIb) Protein, Mouse (HEK293, His) is 328 a.a., with molecular weight of 53-70 kDa.

HY-P78439

	FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) Ach; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P77655

	FGFR-3 alpha (IIIb) Protein, Human (HEK293, His-Avi) Ach; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIb) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 alpha (IIIb) Protein, Human (HEK293, His-Avi) is 355 a.a., with molecular weight of 65-75 kDa.

HY-P77657

	FGFR-3 beta (IIIb) Protein, Human (HEK293, His-Avi) Ach; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIb) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 beta (IIIb) Protein, Human (HEK293, His-Avi) is 249 a.a., with molecular weight of 40-55 kDa.

HY-P78440

	FGFR-3 beta (IIIc) Protein, Human (HEK293, His-Avi) Ach; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P77656

	FGFR-3 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) Ach; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is 355 a.a., with molecular weight of 65-75 kDa.

HY-P77658

	FGFR-3 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) Ach; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is 249 a.a., with molecular weight of 40-55 kDa.

HY-P78124

	FGFR-3 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) Ach; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha IIIc protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78126

	FGFR-3 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) Ach; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta IIIc protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P73056

	FGFR-3 Protein, Mouse (HEK293, His-Fc) Fibroblast growth factor receptor 3; FGFR-3; CD333; JTK4	Mouse	HEK293
	The FGFR-3 Protein is a member of the fibroblast growth factor receptor family. FGFR-3 Protein regulates chondrocyte differentiation and chondrocyte proliferation by activating the MAPK/STAT signaling pathway. FGFR-3 mutations are also associated with sperm cell tumors. FGFR-3 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived FGFR-3 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0282S1

Acetylcholine-d9 chloride

Acetylcholine-d₉ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-B0282S

Acetylcholine-d4 chloride

Acetylcholine-d₄ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-B0282AS1

Acetylcholine-d4 bromide
Acetylcholine-d₄ (bromide) is the deuterium labeled Acetylcholine bromide[1].

HY-B0282AS

Acetylcholine-d9 bromide
Acetylcholine-d₉ (bromide) is the deuterium labeled Acetylcholine bromide .

HY-B0282AS2

Acetylcholine-d13 bromide
Acetylcholine-d₁₃ (bromide) is the deuterium labeled Acetylcholine bromide[1].

HY-B0282AS3

Acetylcholine-d16 bromide
Acetylcholine-d₁₆ (bromide) is the deuterium labeled Acetylcholine bromide[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82871

	Nicotinic Acetylcholine Receptor alpha 4 Antibody (YA2616) Ach4; AchR; Acra4; BFNC; CHRNA4; EBN; EBN1; NAchR; NACRA4	WB, IP	Human, Mouse, Rat
	Nicotinic Acetylcholine Receptor alpha 4 Antibody (YA2616) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2616), targeting Nicotinic Acetylcholine Receptor alpha 4, with a predicted molecular weight of 70 kDa (observed band size: 70 kDa). Nicotinic Acetylcholine Receptor alpha 4 Antibody (YA2616) can be used for WB, IP experiment in human, mouse, rat background.

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