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Results for "

KDM6B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Histone Demethylase (7) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (9)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

GSK-J1 10+ Cited Publications	Histone Demethylase	Cancer
GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and *UTX/KDM6A, with IC₅₀* of 60 nM towards KDM6B.

GSK-J2 2 Publications Verification	Others	Cancer
GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

YUKA1	Histone Demethylase	Cancer
YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC₅₀ of 2.66 μM, less active on KDM5C (IC₅₀, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity .

GSK-J4 hydrochloride Maximum Cited Publications 38 Publications Verification	Histone Demethylase	Cancer
GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases *JMJD3/KDM6B* and *UTX/KDM6A* with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 .

IOX1 10+ Cited Publications	Histone Demethylase	Cancer
IOX1, 5-Carboxy-8-hydroxyquinoline, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC₅₀ values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively . IOX1 also inhibits ALKBH5 .

GSK-J4 Maximum Cited Publications 38 Publications Verification	Histone Demethylase Apoptosis	Cancer
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases *JMJD3/KDM6B* and *UTX/KDM6A* with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 . GSK-J4 induces endoplasmic reticulum stress-related apoptosis .

KDM6B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KDM6B Human Pre-designed siRNA Set A contains three designed siRNAs for KDM6B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KDM6B Human Pre-designed siRNA Set A KDM6B Human Pre-designed siRNA Set A

GSK-J1 lithium salt	Histone Demethylase	Cancer
GSK-J1 lithium salt is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and *UTX/KDM6A, with IC₅₀* of 60 nM towards KDM6B.

GSK-J1 sodium	Histone Demethylase	Cancer
GSK-J1 sodium is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and *UTX/KDM6A, with IC₅₀* value of 60 nM towards KDM6B .

GSK-J2 sodium	Others	Cancer
GSK-J2 sodium is the sodium form of GSK-J2 (HY-15648A). GSK-J2 is an isomer of GSK-J1, and does not have any specific activity. GSK-J1 (HY-15648) is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A .

Cat. No.	Compare	Product Name	Species	Source

	KDM6B Protein, Human (Sf9) KDM6B; Lysine-specific demethylase 6B; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B; [histone H3]-trimethyl-L-lysine(27) demethylase 6B	Human	Sf9 insect cells
	KDM6B protein is a histone demethylase targeting "Lys-27" of histone H3, which mainly affects the histone code. Demethylates H3 "Lys-27" to shape the epigenetic landscape. KDM6B Protein, Human (Sf9) is the recombinant human-derived KDM6B protein, expressed by Sf9 insect cells , with tag free. The total length of KDM6B Protein, Human (Sf9) is 496 a.a., .

	KDM6B Protein, Human (Sf9, His) KDM6B; Lysine-specific demethylase 6B; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B; [histone H3]-trimethyl-L-lysine(27) demethylase 6B	Human	Sf9 insect cells
	KDM6B protein is a histone demethylase targeting "Lys-27" of histone H3, which mainly affects the histone code. Demethylates H3 "Lys-27" to shape the epigenetic landscape. KDM6B Protein, Human (Sf9, His) is the recombinant human-derived KDM6B protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of KDM6B Protein, Human (Sf9, His) is 496 a.a., .

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KDM6B Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
KDM6B Human Pre-designed siRNA Set A contains three designed siRNAs for KDM6B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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