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Ketoconazole-d<sub>8</sub>

" in MedChemExpress (MCE) Product Catalog:

2910

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8

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4

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1

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9

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Products

13

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2841

Isotope-Labeled Compounds

3

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16

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1

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0105S1
    Ketoconazole-d4

    Ketoconazol-d<sub>4sub>; R 41400-d<sub>4sub>

    		 Fungal Cytochrome P450 Ras Infection Cancer
    Ketoconazole-d4 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole-d4
  • HY-B0105S
    Ketoconazole-d8

    		Fungal Cytochrome P450 Ras Infection Cancer
    Ketoconazole-d8 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole-d8
  • HY-G0021S1
    N-Desmethylclozapine-d8 hydrochloride

    Norclozapine-d<sub>8sub> hydrochloride; Desmethylclozapine-d<sub>8sub> hydrochloride; Normethylclozapine-d<sub>8sub> hydrochloride

    		 mAChR Opioid Receptor Drug Metabolite Virus Protease Infection
    N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].
    N-Desmethylclozapine-d8 hydrochloride
  • HY-B0105BS
    (-)-Ketoconazole-d3

    (-)-Ketoconazol-d<sub>3sub>; (-)-R 41400-d<sub>3sub>

    		 Fungal Infection Inflammation/Immunology
    (-)-Ketoconazole-d3 is deuterium labeled (-)-Ketoconazole. (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole).
    (-)-Ketoconazole-d3
  • HY-RS13999
    SUB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SUB1 Human Pre-designed siRNA Set A
    SUB1 Human Pre-designed siRNA Set A
  • HY-146227
    DNA topoisomerase II inhibitor 1

    		Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .
    DNA topoisomerase II inhibitor 1
  • HY-10844S1
    Pretomanid-d5

    PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>

    		 Antibiotic Bacterial Isotope-Labeled Compounds Infection Cancer
    Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
    Pretomanid-d5
  • HY-B0615AS
    Moricizine-d8(Hydrochloride)

    EN 313-d<sub>8sub>; Ethmozin-d<sub>8sub>; Moracizine-d<sub>8sub>

    		 Isotope-Labeled Compounds Cardiovascular Disease
    Moricizine-d8 (Hydrochloride) is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1][2].
    Moricizine-d8(Hydrochloride)
  • HY-G0021S
    N-Desmethylclozapine-d8

    Norclozapine-d<sub>8sub>; Desmethylclozapine-d<sub>8sub>; Normethylclozapine-d<sub>8sub>

    		 mAChR Opioid Receptor Drug Metabolite Virus Protease Infection
    N-Desmethylclozapine-d8 is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].
    N-Desmethylclozapine-d8
  • HY-17037S1
    Pirenzepine-d8 dihydrochloride

    LS 519-d<sub>8sub> dihydrochloride; Pirenzepin-d<sub>8sub> dihydrochloride; Gastrozepin-d<sub>8sub> dihydrochloride

    		 Isotope-Labeled Compounds Cancer
    Pirenzepine-d8 (LS 519-d8; Pirenzepin-d8) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .
    Pirenzepine-d8 dihydrochloride
  • HY-17037S
    Pirenzepine-d8

    LS 519-d<sub>8sub> free base; Pirenzepin-d<sub>8sub>; Gastrozepin-d<sub>8sub>

    		 Isotope-Labeled Compounds mAChR Neurological Disease Inflammation/Immunology
    Pirenzepine-d8 is the deuterium labeled Pirenzepine dihydrochloride. Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.
    Pirenzepine-d8
  • HY-10227S
    Bortezomib-d8

    PS-341-d<sub>8sub>; LDP-341-d<sub>8sub>; NSC 681239-d<sub>8sub>

    		 Proteasome NF-κB Apoptosis Autophagy Cancer
    Bortezomib-d8 is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity[1][2].
    Bortezomib-d8
  • HY-13011S
    Alectinib-d8

    CH5424802-d<sub>8sub>; RO5424802-d<sub>8sub>; AF802-d<sub>8sub>

    		 Anaplastic lymphoma kinase (ALK) Cancer
    Alectinib-d8 is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].
    Alectinib-d8
  • HY-13463BS
    Avatrombopag-d8 hydrochloride

    AKR-501-d<sub>8sub> hydrochloride; E5501-d<sub>8sub> hydrochloride; YM477-d<sub>8sub> hydrochloride

    		 Isotope-Labeled Compounds Thrombopoietin Receptor Cardiovascular Disease
    Avatrombopag-d8 (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3].
    Avatrombopag-d8 hydrochloride
  • HY-14740S
    Elvitegravir-d8

    GS-9137-d<sub>8sub>; JTK-303-d<sub>8sub>; D06677-d<sub>8sub>

    		 Isotope-Labeled Compounds HIV Integrase HIV Infection
    Elvitegravir-d8 is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
    Elvitegravir-d8
  • HY-15531S
    Venetoclax-d8

    ABT-199-d<sub>8sub>; GDC-0199-d<sub>8sub>; RG7601-d<sub>8sub>

    		 Bcl-2 Family Autophagy Cancer
    Venetoclax-d8 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].
    Venetoclax-d8
  • HY-15581S
    MMAD-d8

    Demethyldolastatin 10-d<sub>8sub>; Monomethylauristatin D-d<sub>8sub>; Monomethyl Dolastatin 10-d<sub>8sub>

    		 ADC Cytotoxin Microtubule/Tubulin Cancer
    MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
    MMAD-d8
  • HY-B0104S2
    Glimepiride-d8

    Glimperide-d<sub>8sub>; HOE-490-d<sub>8sub>

    		 Amyloid-β Isotope-Labeled Compounds Metabolic Disease
    Glimepiride-d8 (Glimperide-d8; HOE-490-d8) is deuterium-labeled Glimepiride (HY-B0104) .
    Glimepiride-d8
  • HY-B0272S1
    Rifampicin-d8

    Rifampin-d<sub>8sub>; Rifamycin AMP-d<sub>8sub>

    		 Bacterial Influenza Virus Antibiotic Infection
    Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.
    Rifampicin-d8
  • HY-N0378S
    D-Mannitol-d8

    Mannitol-d<sub>8sub>; Mannite-d<sub>8sub>

    		 Endogenous Metabolite Apoptosis Metabolic Disease
    D-Mannitol-d8 is the deuterium labeled D-Mannitol. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.
    D-Mannitol-d8
  • HY-13502S
    Mitoxantrone-d8

    Mitozantrone-d<sub>8sub>; NSC 301739-d<sub>8sub>

    		 Isotope-Labeled Compounds Topoisomerase PKC Cancer
    Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM[1][2].
    Mitoxantrone-d8
  • HY-N0007S
    Bisdemethoxycurcumin-d8

    Curcumin III-d<sub>8sub>; Didemethoxycurcumin-d<sub>8sub>

    		 Apoptosis Autophagy Cancer
    Bisdemethoxycurcumin-d8 is the deuterium labeled Bisdemethoxycurcumin. Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.
    Bisdemethoxycurcumin-d8
  • HY-N0623S5
    L-Tryptophan-d8

    Tryptophan-d<sub>8sub>; Tryptophane-d<sub>8sub>

    		 Endogenous Metabolite Metabolic Disease
    L-Tryptophan-d8 is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
    L-Tryptophan-d8
  • HY-13502AS
    Mitoxantrone-d8 dihydrochloride

    Mitozantrone-d<sub>8sub>(dihydrochloride); NSC 301739-d<sub>8sub> dihydrochloride

    		 Endogenous Metabolite PKC Apoptosis Topoisomerase Orthopoxvirus Isotope-Labeled Compounds Infection Cancer
    Mitoxantrone-d8 dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
    Mitoxantrone-d8 dihydrochloride
  • HY-90001S2
    Ritonavir-d8

    ABT 538-d<sub>8sub>; RTV-d<sub>8sub>

    		 Apoptosis HIV Protease SARS-CoV HIV Isotope-Labeled Compounds Infection Cancer
    Ritonavir-d8 is deuterated labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.61 μM.
    Ritonavir-d8
  • HY-34444S
    1,1-Dioxothiolan-d8

    Bondelane A-d<sub>8sub>; Cyclic tetramethylene sulfone-d<sub>8sub>; Cyclotetramethylene sulfone-d<sub>8sub>

    		 Isotope-Labeled Compounds Others
    1,1-Dioxothiolan-d8 is the deuterium labeled 1,1-Dioxothiolan[1].
    1,1-Dioxothiolan-d8
  • HY-B1955S
    4',4-Dibromobiphenyl-d8

    NSC 2098-d<sub>8sub>; PBB 15-d<sub>8sub>; p,p'-Dibromobiphenyl-d<sub>8sub>

    		 Isotope-Labeled Compounds Others
    4',4-Dibromobiphenyl-d8 is the deuterium labeled 4',4-Dibromobiphenyl[1].
    4',4-Dibromobiphenyl-d8
  • HY-B1895S
    Levodropropizine-d8

    (S)-(-)-Dropropizine-d<sub>8sub>; DF-526-d<sub>8sub>

    		 Isotope-Labeled Compounds Histamine Receptor Inflammation/Immunology Endocrinology
    Levodropropizine-d8 is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.
    Levodropropizine-d8
  • HY-107434S
    Molindone-d8

    (±)-Molindone-d<sub>8sub>; SPN-810M-d<sub>8sub>

    		 Isotope-Labeled Compounds Dopamine Receptor Neurological Disease
    Molindone-d8 is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses[1][2].
    Molindone-d8
  • HY-13593S
    Chlorambucil-d8

    CB-1348-d<sub>8sub>; WR-139013-d<sub>8sub>

    		 Isotope-Labeled Compounds DNA Alkylator/Crosslinker Cancer
    Chlorambucil-d8 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].
    Chlorambucil-d8
  • HY-B0400S
    D-Sorbitol-d8

    Sorbitol-d<sub>8sub>; D-Glucitol-d<sub>8sub>

    		 Endogenous Metabolite Others
    D-Sorbitol-d8 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1].
    D-Sorbitol-d8
  • HY-G0016S2
    N-Acetyl dapsone-d8

    MADDS-d<sub>8sub>; Monoacetyldapsone-d<sub>8sub>

    		 Isotope-Labeled Compounds Others
    N-Acetyl Dapsone-d8 is the deuterium labeled N-Acetyl Dapsone[1].
    N-Acetyl dapsone-d8
  • HY-17401S
    Ranolazine-d8 dihydrochloride

    CVT 303-dd<sub>8sub> dihydrochloride; RS 43285-d<sub>8sub>

    		 Calcium Channel Sodium Channel Autophagy Cardiovascular Disease Cancer
    Ranolazine-d8 (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3].
    Ranolazine-d8 dihydrochloride
  • HY-10162S1
    Olaparib-d8

    AZD2281-d<sub>8sub>; KU0059436-d<sub>8sub>

    		 PARP Autophagy Mitophagy Cancer
    Olaparib-d8 is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].
    Olaparib-d8
  • HY-100665S
    Dehydroaripiprazole-d8

    OPC-14857-d<sub>8sub>; DM-14857-d<sub>8sub>

    		 Isotope-Labeled Compounds 5-HT Receptor Neurological Disease
    Dehydroaripiprazole-d8 is deuterium labeled Dehydroaripiprazole. Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole[1][2][3].
    Dehydroaripiprazole-d8
  • HY-14667S
    Lomitapide-d8

    AEGR-733-d<sub>8sub>; BMS-201038-d<sub>8sub>

    		 Isotope-Labeled Compounds Cardiovascular Disease
    Lomitapide-d8 is deuterium labeled Lomitapide. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
    Lomitapide-d8
  • HY-W009247S
    N-Desmethylolanzapine-d8

    N-Demethylolanzapine-d<sub>8sub>; LY170055-d<sub>8sub>

    		 Isotope-Labeled Compounds Others
    N-Desmethylolanzapine-d8 is deuterium labeled N-Desmethylolanzapine.
    N-Desmethylolanzapine-d8
  • HY-132386S
    Imatinib-d8 mesylate

    STI571-d<sub>8sub> mesylate; CGP-57148B-d<sub>8sub> mesylate

    		 Isotope-Labeled Compounds Others
    Imatinib-d8 (mesylate) is the deuterium labeled Imatinib mesylate[1].
    Imatinib-d8 mesylate
  • HY-W013376S
    Norcyclizine-d8

    1-(Diphenylmethyl)piperazine-d<sub>8sub>; 1-Benzhydrylpiperazine-d<sub>8sub>

    		 Isotope-Labeled Compounds Cancer
    Norcyclizine-d8 is the deuterium labeled Norcyclizine .
    Norcyclizine-d8
  • HY-15463S
    Imatinib-d8
    1 Publications Verification

    STI571-d<sub>8sub>; CGP-57148B-d<sub>8sub>

    		 Bcr-Abl PDGFR c-Kit SARS-CoV Autophagy Cancer
    Imatinib-d8 is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].
    Imatinib-d8
  • HY-B0688S
    Dapsone-d8

    4,4′-Diaminodiphenyl sulfone-d<sub>8sub>; DDS-d<sub>8sub>

    		 Antibiotic Parasite Bacterial Reactive Oxygen Species Infection Inflammation/Immunology Cancer
    Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].
    Dapsone-d8
  • HY-12522S
    PF-06380101-d8
    2 Publications Verification

    Aur0101-d<sub>8sub>; Auristatin-0101-d<sub>8sub>

    		 Microtubule/Tubulin ADC Cytotoxin Cancer
    PF-06380101-d8 is a deuterium labeled PF-06380101. PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue[1].
    PF-06380101-d8
  • HY-12678S1
    Entrectinib-d8

    NMS-E628-d<sub>8sub>; RXDX-101-d<sub>8sub>

    		 Isotope-Labeled Compounds Autophagy Anaplastic lymphoma kinase (ALK) Trk Receptor ROS Kinase Cancer
    Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC50 values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .
    Entrectinib-d8
  • HY-W009247S1
    N-Desmethylolanzapine-d8 hydrochloride

    N-Demethylolanzapine-d<sub>8sub> hydrochloride; LY170055-d<sub>8sub> hydrochloride

    		 Isotope-Labeled Compounds Neurological Disease
    N-Desmethylolanzapine-d8 hydrochloride (N-Demethylolanzapine-d8 hydrochloride) is the deuterium labeled N-Desmethylolanzapine (HY-W009247). N-Desmethylolanzapine is an antipsychotic drug. The formation of N-Desmethylolanzapine correlates with the level and activity of human liver flavin-containing monooxygenase (FMO3). N-Desmethylolanzapine can be used in the study of antipsychotic drugs .
    N-Desmethylolanzapine-d8 hydrochloride
  • HY-Y0921S
    (±)-1,2-Propanediol-d8

    1,2-(RS)-Propanediol-d<sub>8sub>; 1,2-Propylene glycol-d<sub>8sub>; Propylene glycol-d<sub>8sub>

    		 Endogenous Metabolite Isotope-Labeled Compounds Others
    (±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents.
    (±)-1,2-Propanediol-d8
  • HY-W062703S1
    (Rac)-Ruxolitinib-d8

    (Rac)-INCB18424-d<sub>8sub>; Ruxotinib racemate-d<sub>8sub>

    		 Isotope-Labeled Compounds Others
    (Rac)-Ruxolitinib-d8 is deuterium labeled (Rac)-Ruxolitinib.
    (Rac)-Ruxolitinib-d8
  • HY-117605S
    N-Desmethyl Sildenafil-d8

    Desmethylsildenafil-d<sub>8sub>; UK-103,320-d<sub>8sub>

    		 Phosphodiesterase (PDE) Isotope-Labeled Compounds Neurological Disease Cancer
    N-Desmethyl Sildenafil-d8 is the deuterium labeled N-Desmethyl Sildenafil (HY-117605). N-Desmethyl Sildenafil is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2][3].
    N-Desmethyl Sildenafil-d8
  • HY-B1342S
    Retinol-d8

    Vitamin A1-d<sub>8sub>; all-trans-Retinol-d<sub>8sub>

    		 Endogenous Metabolite Metabolic Disease
    Retinol-d8 is the deuterium labeled Retinol. Retinol is an endogenous metabolite.
    Retinol-d8
  • HY-136433S
    N,N'-Dinitrosopiperazine-d8

    1,4-Dinitrosopiperazine-d<sub>8sub>; DNP-d<sub>8sub>

    		 Isotope-Labeled Compounds Cancer
    N,N'-Dinitrosopiperazine-d8 is the deuterium labeled N,N'-Dinitrosopiperazine[1]. N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568[2].
    N,N'-Dinitrosopiperazine-d8
  • HY-13690S2
    Mitotane-d8

    2,4′-DDD-d<sub>8sub>; o,p'-DDD-d<sub>8sub>

    		 Apoptosis Cancer
    Mitotane-d8 is the deuterium labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].
    Mitotane-d8

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