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NAD

" in MedChemExpress (MCE) Product Catalog:

147

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3

Fluorescent Dye

7

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1

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32

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31

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16

Isotope-Labeled Compounds

6

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1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0445A
    NAD sodium
    20+ Cited Publications

    β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium

    Endogenous Metabolite Metabolic Disease
    NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .
    NAD sodium
  • HY-P2996

    Others Others
    NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants, the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .
    NAD(P)H-Nitrate reductase
  • HY-10351A

    NAD-​299 hydrochloride

    5-HT Receptor Neurological Disease
    Robalzotan hydrochloride (NAD-​299 hydrochloride) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan hydrochloride increases the firing rate of 5-HT cells. Robalzotan hydrochloride induces 5-HT1A receptor occupancy. Robalzotan hydrochloride has the potential for the research of a cholinergic deficit in the central -nervous system .
    Robalzotan hydrochloride
  • HY-B0445
    NAD+
    20+ Cited Publications

    β-DPN; β-NAD; β-Nicotinamide Adenine Dinucleotide

    Endogenous Metabolite Metabolic Disease
    NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
    NAD+
  • HY-W654288

    β-DPN-d4; β-NAD-d4; β-Nicotinamide Adenine Dinucleotide-d4

    Isotope-Labeled Compounds Others
    NAD+-d4 is the deuterium-labeled NAD+ (HY-B0445). NAD+-d4 is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
    NAD+-d4
  • HY-P3186A

    GDH-NAD

    Endogenous Metabolite Others
    NAD-dependent Glucose dehydrogenase (EC 1.1.1.47) is an enzyme used as a regeneration cofactor to convert glucose and NAD(P) into NAD(P)H and gluconic acid .
    NAD-dependent Glucose dehydrogenase
  • HY-E70410

    NAD+ Synthetase; Nicotinamide adenine dinucleotide synthetase

    Endogenous Metabolite Neurological Disease Metabolic Disease Cancer
    NAD synthetase is responsible for the final step in the synthesis of nicotinamide adenine dinucleotide (NAD). The Km values for NAD, ATP, and ammonia of NAD synthetase from Escherichia coli are 200 μM, 11 μM, and 0.65 μM, respectively, while the Km values for NAD, ATP, and ammonia of NAD synthetase from yeast are 170 μM, 190 μM, and 64 μM, respectively. NAD synthetase can be used for enzymatic assays to determine ATP, ammonia, urea, or creatinine, and is also suitable for enzymatic cycling methods. Additionally, NAD synthetase holds potential for research into metabolic diseases, cancer, aging, and neurodegenerative diseases .
    NAD Synthetase
  • HY-B0445R

    Endogenous Metabolite Metabolic Disease
    NAD+ (Standard) is the analytical standard of NAD+. This product is intended for research and analytical applications. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. In Vitro: NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. NAD+ is the oxidized form of NADH . NAD+ is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (Nadide) . In Vivo: Oral NAD+ supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia .
    NAD+ (Standard)
  • HY-W250163

    β-DPN lithium; β-NAD lithium; β-Nicotinamide Adenine Dinucleotide lithium

    Biochemical Assay Reagents Metabolic Disease
    NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function .
    NAD+ lithium
  • HY-10351

    NAD-​299

    5-HT Receptor Neurological Disease
    Robalzotan (NAD-​299) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan increases the firing rate of 5-HT cells. Robalzotan induces 5-HT1A receptor occupancy. Robalzotan has the potential for the research of a cholinergic deficit in the central -nervous system .
    Robalzotan
  • HY-B0445S1

    β-DPN-13C5; β-NAD-13C5; β-Nicotinamide Adenine Dinucleotide-13C5

    Endogenous Metabolite Metabolic Disease
    NAD+- 13C5-1 is the 13C labeled NAD+[1]. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
    NAD+-13C5
  • HY-B0445S

    β-DPN-13C5 ammonium; β-NAD-13C5 ammonium; β-Nicotinamide Adenine Dinucleotide-13C5 ammonium

    Isotope-Labeled Compounds Metabolic Disease
    NAD+-13C5 (ammonium) is the 13C labled NAD+ (HY-B0445), with an ammonium .
    NAD+-13C5 ammonium
  • HY-131009

    PARP Others
    Fluorescein-NAD+ is an alternative to radiolabeled NAD and a substrate for ADP-ribosylation. Fluorescein-NAD+ can be used in PARP assays by fluorescence microscopy. Extinction Coefficient: 262 nm.
    Fluorescein-NAD+
  • HY-134358

    CD38 Neurological Disease
    Ara-F-NAD+ is an arabino analogue of NAD +. Ara-F-NAD+ is a potent, reversible and slow-binding CD38 NADase inhibitor .
    Ara-F-NAD+
  • HY-134358A

    CD38 Neurological Disease
    Ara-F-NAD+ sodium is an arabino analogue of NAD +. Ara-F-NAD+ sodium is a potent, reversible and slow-binding CD38 NADase inhibitor .
    Ara-F-NAD+ sodium
  • HY-137673A

    Others Others
    2'-Deoxy-NAD+ sodium is the sodium salt form of 2'-Deoxy-NAD+ (HY-137673). 2'-Deoxy-NAD+ sodium is a noncompetitive inhibitor of NAD+ with a Ki of 32 μM. 2'-Deoxy-NAD+ sodium can be used as a substrate to study ADP-ribosyl transfer reactions.
    2'-Deoxy-NAD+ sodium
  • HY-131485A

    3-APAD, 95%; 3-Acetylpyridine NAD, 95%

    Lactate Dehydrogenase Metabolic Disease
    3-Acetylpyridine adenine dinucleotide, 95% (3-APAD, 95%)is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 95% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .
    3-Acetylpyridine adenine dinucleotide, 95%
  • HY-127127

    Others Others
    Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a Km of 2300 pm, and a Kd of 112 pm .
    Deamino-NAD
  • HY-127127A

    Others Others
    Deamino-NAD sodium is a structural analog of NAD+ (HY-B0445). Deamino-NAD sodium is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a Km of 2300 pm, and a Kd of 112 pm .
    Deamino-NAD sodium
  • HY-117029

    Deamido NAD sodium

    Endogenous Metabolite Metabolic Disease
    NAAD sodium (Deamido nad sodium), a functional NAD + precursor, is the substrate of glutamine-dependent NAD + synthetase. NAAD sodium is used to study the structure of nicotinate mononucleotide adenylyltransferases .
    NAAD sodium
  • HY-137673

    Others Others
    2'-Deoxy-NAD+ is a noncompetitive inhibitor for NAD + with a Ki of 32 μM. 2'-Deoxy-NAD+ can be utilized as a substrate to study the ADP-ribosyl transfer reaction .
    2'-Deoxy-NAD+
  • HY-134279

    Others Others
    8-Br-NAD+ sodium is an NAD+ derivative that acts as a substrate for transfer to diversely modified ADP-ribosylated molecules .
    8-Br-NAD+ sodium
  • HY-P2947

    Aldehyde dehydrogenase (NAD(P))

    Aldehyde Dehydrogenase (ALDH) Others Cancer
    ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress .
    ALDH
  • HY-E70238

    Nicotinamide 2-azidoadenine dinucleotide

    Others Others
    2-Azido-NAD is a NAD + analog that can be used for visualization of intracellular Poly(ADP ribos)ylation (PARylation) processes .
    2-Azido-NAD
  • HY-131924

    Thio-NAD

    Biochemical Assay Reagents Others
    Thionicotinamide adenine dinucleotide (Thio-NAD) is a dinucleotide substrate .
    Thionicotinamide adenine dinucleotide
  • HY-B0445B

    α-Nicotinamide Adenine Dinucleotide

    Others Others
    α-NAD (α-Nicotinamide Adenine Dinucleotide) serves as a substrate for renalase and functions as an analog of β-NAD, influencing the kinetics of NAD-dependent enzymes, while also playing a crucial role as a cofactor in mitochondrial oxidation-reduction reactions.
    α-NAD
  • HY-144776

    NAMPT Neurological Disease Cancer
    NAT is an initial hit of NAMPT activator. NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the research of many diseases associated with NAD exhaustion such as neurodegenerative diseases .
    NAT
  • HY-P2911

    GLDH

    Mitochondrial Metabolism Others
    Glutamate dehydrogenase NAD(P) (GLDH) can be found in hepatocytes, renal tissue, brain, muscle, and intestinal cells. Glutamate dehydrogenase NAD(P) is often used in biochemical studies. Glutamate dehydrogenase is a mitochondrial enzyme, it catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate (α-KG) as part of the urea cycle .
    Glutamate dehydrogenase (NAD(P))
  • HY-P2996B

    Others Others
    Nitrate Reductase (NAD[P]H), Pichia pastoris (recombinant) is a simplified version of nitrate reductase S-NaR1 expressed and purified by Pichia pastoris. Nitrate Reductase (NAD[P]H), Pichia Pastoris (recombinant) contains sites binding molybdenum-molybdenopyridine (Mo-MPT) and nitrate reduction active sites and only contains two domains instead of the five domains of the complete NaR. This simplified form of nitrate reductase was expressed in high density in P. pastoris and purified to homogeneity in one step by fixed metal affinity chromatography (IMAC). Nitrate Reductase (NAD[P]H), Pichia Pastoris (recombinant) can be used in the development of biosensors and environmental monitoring .
    Nitrate Reductase (NAD[P]H), Pichia Pastoris (recombinant)
  • HY-137592

    ε-NAD

    Fluorescent Dye Others
    Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) , a fluorescent analogue of NAD, is able to serve as a substrate for the bacterial toxincatalyzed G-ADP ribosylation of signal-transducing G-proteins. Nicotinamide 1,N6-ethenoadenine dinucleotide can be used as a fluorescent substrate for the studies of the ADP ribosylation reaction .
    Nicotinamide 1,N6-ethenoadenine dinucleotide
  • HY-147342

    Others Others
    β-Benzamide adenine dinucleotide is a bioactive metabolite of benzamide nucleoside and a potent inhibitor of inosine 5 '-monophosphate dehydrogenase (IMPDH). β-Benzamide adenine dinucleotide is a potent, competitive inhibitor of human NAD kinase (Ki = 90 µM) .
    β-Benzamide adenine dinucleotide
  • HY-131485

    3-APAD, 90%; 3-Acetylpyridine NAD, 90%

    Lactate Dehydrogenase Metabolic Disease
    3-Acetylpyridine adenine dinucleotide, 90% is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 90% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .
    3-Acetylpyridine adenine dinucleotide, 90%
  • HY-E70408

    Endogenous Metabolite Metabolic Disease
    12α-Hydroxysteroid dehydrogenase, bacillus sphaericus is a dehydrogenase expressed in Bacillus sphaericus. 12α-Hydroxysteroid dehydrogenase, bacillus sphaericus is NAD-dependent and is active on both bound and unbound bile salts. This enzyme can be used to measure the concentration of 12α-hydroxy bile acids in serum .
    12α-Hydroxysteroid dehydrogenase, bacillus sphaericus
  • HY-P2807F

    LAD, LD, L-LDH, (S)-Lactate: NAD+ oxidoreductase

    Others Others
    Lactate Dehydrogenase (LDH), Bovine Heart (LAD, LD, L-LDH, (S)-Lactate: NAD+ oxidoreductase) is a biological material or organic compound that can be used in life science research .
    Lactate Dehydrogenase (LDH), Bovine Heart
  • HY-161712

    Others Cancer
    Nampt-IN-12 (compound 9) is a derivative of N-Pyridinylthiophene carboxamide, exhibiting activity against peripheral nerve sheath tumor cells. Nampt-IN-12 is metabolized via the enzymes NAMPT and NMNAT1, both integral to the NAD salvage pathway, into an adenosine diphosphate (AD) derivative, which is an analog of NAD and capable of inhibiting inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within cells. With its favorable ability to cross the blood-brain barrier, Nampt-IN-12 holds potential for research in cancers affecting both the central and peripheral nervous systems .
    Nampt-IN-12
  • HY-F0004
    β-Nicotinamide mononucleotide
    10+ Cited Publications

    β-NM; NMN

    Endogenous Metabolite Neurological Disease Cancer
    β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD + intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .
    β-Nicotinamide mononucleotide
  • HY-113432

    2PY

    Endogenous Metabolite PARP Metabolic Disease
    Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .
    Nudifloramide
  • HY-108631
    EB-47 dihydrochloride
    2 Publications Verification

    PARP Inflammation/Immunology
    EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD + and extends from the nicotinamide to the adenosine subsite .
    EB-47 dihydrochloride
  • HY-15046

    PARP Cardiovascular Disease Inflammation/Immunology
    EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD + and extends from the nicotinamide to the adenosine subsite .
    EB-47
  • HY-W104368

    Endogenous Metabolite Metabolic Disease Cancer
    Nicotinic acid riboside is a NAD + precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD + metabolism .
    Nicotinic acid riboside
  • HY-P2996A

    Others Others
    Nitrate Reductase, Arabidopsis thaliana is the isomer of NAD(P)H-Nitrate reductase (HY-P2996). NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants,the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .
    Nitrate Reductase, Arabidopsis thaliana
  • HY-D0808

    Fluorescent Dye
    Meldola blue is a biosensor for measuring lactate in serum based on screen-printed carbon electrodes modified with Meldola's Blue-Reinecke salt (MBRS-SPCE) coated with lactate dehydrogenase NAD+-dependent enzyme (from pig heart) and NAD+.
    Meldola blue
  • HY-128895
    KL1333
    1 Publications Verification

    Mitochondrial Metabolism Metabolic Disease
    KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .
    KL1333
  • HY-159009

    NAMPT Cancer
    MS7 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). NAMPT is the rate-limiting enzyme in the NAD + biosynthetic pathway, responsible for converting nicotinamide to nicotinamide mononucleotide, which is then converted to NAD +. NAMPT is overexpressed in many cancer cells to meet the continuous replenishment of NAD + required for rapid proliferation. PROTAC A7, a derivative of MS7, is an effective NAMPT degrader. MS7 can be used in cancer research .
    MS7
  • HY-E70014

    FAD-GDH; Glucose 1-dehydrogenase

    Endogenous Metabolite Others
    FAD-dependent glucose dehydrogenase (EC 1.1.5.9), or glucose dehydrogenase (FAD)/Pseudomonas glucose dehydrogenase. Glucose 1-dehydrogenase is an enzyme used as a regeneration cofactor to convert glucose and NAD(P) into NAD(P)H and gluconic acid .
    FAD-dependent glucose dehydrogenase
  • HY-163445

    NAMPT Cancer
    NAMPT activator-6 is a NAMPT activator, a regulatory molecule for the optical control system of NAMPT and NAD+. NAMPT activator-6 can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) to achieve up-down reversible regulation of NAMPT and NAD+ in a light-dependent manner and reduce the toxicity associated with inhibitor-based PS-PROTACs. PS-PROTAC can be used to achieve antitumor activity, NAMPT, and NAD+ modulation in vivo via optical manipulation .
    NAMPT activator-6
  • HY-P2993

    ICDH; IDH

    Isocitrate Dehydrogenase (IDH) Metabolic Disease Cancer
    Isocitrate dehydrogenase, Porcine heart (ICDH) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P) + to NAD(P)H, it plays important roles in cellular metabolism .
    Isocitrate dehydrogenase, Porcine heart
  • HY-B0150S
    Nicotinamide-d4
    1 Publications Verification

    Niacinamide-d4; Nicotinic acid amide-d4

    Sirtuin Endogenous Metabolite Neurological Disease Cancer
    Nicotinamide-d4 is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
    Nicotinamide-d4
  • HY-W615108B

    NMNH, reduced form disodium

    Endogenous Metabolite Cancer
    β-Nicotinamide mononucleotide, reduced form disodium (β-NMN) is the oxidized form of NAD+ precursor and is a NAD+ enhancer. β-Nicotinamide mononucleotide, reduced form disodium can be reduced to dihydronicotinamide mononucleotide (NMNH). NMNH inhibits glycolysis, TCA cycle, and cell growth .
    β-Nicotinamide mononucleotide, reduced form disodium
  • HY-B0150S2

    Niacinamide-13C6; Nicotinic acid amide-13C6

    Endogenous Metabolite Sirtuin Neurological Disease Cancer
    Nicotinamide- 13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
    Nicotinamide-13C6

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