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OC43

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By Targets:	HSV (1) Influenza Virus (2) PI3K (1) PROTACs (2) Protein Arginine Deiminase (1) RSV (1) SARS-CoV (11) Virus Protease (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (10) Inflammation/Immunology (1)

12

Inhibitors & Agonists

2

Natural
Products

6

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*HCoV-OC43-IN-1*	SARS-CoV	Infection
HCoV-OC43-IN-1 (Compound IV-16) is a coronavirus *HCoV-OC43* inhibitor. HCoV-OC43-IN-1 has antiviral efficacy (EC₅₀: 90 nM). HCoV-OC43-IN-1 inhibits the mRNA level and expression of viral nucleocapsid protein (NP) .

Vps34-IN-2 2 Publications Verification	PI3K SARS-CoV	Cancer
Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34 with IC₅₀s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively . Vps34-IN-2 shows antiviral activity against SARS-CoV-2 (IC₅₀ of 3.1 μM), HCoV-229E (IC₅₀ of 0.7 μM) and *HCoV-OC43* .

Antiviral agent 58	SARS-CoV Influenza Virus RSV HSV	Infection
Antiviral agent 58 (Compound J1) is an orally active antiviral agent with broad-spectrum antiviral activity against enveloped viruses, including influenza A virus (IAV), respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human coronavirus OC43 (HCoV-OC43), herpes simplex virus type 1 (HSV-1), and HSV-2 .

Isocannflavin B Caflanone	SARS-CoV	Infection
Isocannflavin B (Caflanone) is a flavonoid and can be isolated from Cannabis sativaL. Isocannflavin B inhibits *HCoV-OC43* with an EC₅₀ value of 0.42 µM .

SARS-CoV-2-IN-93	SARS-CoV	Infection
SARS-CoV-2-IN-93 (compound 24) is an inhibitor of SARS-CoV-2 and *HCoV-OC43*. SARS-CoV-2-IN-93 can be used in antiviral research .

SARS-CoV-2-IN-96	SARS-CoV	Infection
SARS-CoV-2-IN-96 (compound 12b) is an inhibitor of HCoV-OC43 (EC₅₀= 97 nM) and SARS-CoV-2 (EC₅₀= 45 nM) and low cytotoxicity (CC₅₀> 10 μM) in Huh7 cells .

Antiviral agent 54	Virus Protease Influenza Virus SARS-CoV	Infection
Antiviral agent 54 (compound 33) is a broad-spectrum and orally active antiviral agent. Antiviral agent 54 shows antiviral activity for ZIKV, *HCoV-OC43* and influenza A virus (IVA). Antiviral agent 54 decreases the ZIKV RNA and protein level .

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one	SARS-CoV	Infection
1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one is a potent nucleocapsid (N) protein inhibitor can be isolated from Curcuma kwangsiensis. 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one exhibits excellent antiviral activity against HCoV-OC43 and SARS-CoV-2,with EC₅₀ values of 0.16 μM and 0.17 μM, respectively .

PROTAC SARS-CoV-2 Mpro degrader-2	PROTACs SARS-CoV	Infection
PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of SARS-CoV-2 M ^pro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC₅₀ = 10.8 μM), HCoV-OC43 (EC₅₀ = 1.6 μM) and HCoV-229E (EC₅₀ = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC₅₀ of 0.89 μM .

PROTAC SARS-CoV-2 Mpro degrader-3	PROTACs SARS-CoV Virus Protease	Infection
PROTAC SARS-CoV-2 Mpro degrader-3 (Compound P2) exhibits antiviral activity through the degradation of the main protease (Mpro) of human coronaviruses (HCoVs) (DC₅₀=27 μM). PROTAC SARS-CoV-2 Mpro degrader-3 inhibits the viral replication, with EC₅₀ of 4.6 μM, 4.6 μM, and 0.71 μM, for human coronaviruses HCoV-229E, HCoV-OC43 and SARS-CoV-2, respectively. (Pink: ligand for target protein Mpro ligand 2 (HY-161791); Black: linker (HY-161792); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845)) .

SARS-CoV-IN-5	SARS-CoV	Infection
SARS-CoV-IN-5 (compound 49) is a highly selective, nonpeptidic and noncovalent 3CL ^pro inhibitor with IC₅₀s of 38 nM, 21.1 nM and 86 nM for 3CL ^pro of SARS-CoV-1, SARS-CoV-2, Bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the SARS-CoV-2 delta variant with an EC₅₀ of 0.272 μM. SARS-CoV-IN-5 significantly reduces the lung viral copies in a K18-hACE2 transgenic mouse model. SARS-CoV-IN-5 has good target-specific and potential broad-spectrum anticoronavirus activities against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9 .

GSK199	Protein Arginine Deiminase	Cardiovascular Disease Inflammation/Immunology Cancer
GSK199 is an orally active, reversible, and selective PAD4 inhibitor with an IC₅₀ of 200 nM in the absence of calcium. GSK199 can be used for the research of rheumatoid arthritis .

Species:	Virus (6)
Tag:	His (6) Myc (1)
Source:	HEK293 (2) Sf9 insect cells (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	*HCoV-OC43* Spike/S Protein (Sf9, His, myc)** E2; Peplomer protein ; Human coronavirus OC43 Spike glycoprotein	Virus	Sf9 insect cells
	HCoV-OC43 Spike/S Protein, particularly the S1 subunit, initiates infection by attaching the virion to the cell membrane. It interacts with sialic acid-containing cell receptors, facilitating virus binding and marking the initial step in the infection process, establishing a connection with the host receptor for infection commencement. HCoV-OC43 Spike/S Protein (Sf9, His, myc) is the recombinant Virus-derived HCoV-OC43 Spike/S protein, expressed by Sf9 insect cells , with C-Myc, N-10*His labeled tag. The total length of HCoV-OC43 Spike/S Protein (Sf9, His, myc) is 330 a.a., with molecular weight of ~41.0 kDa.

	*HCoV-OC43* Nucleoprotein/NP Protein (His)** Human coronavirus (HCoV-OC43) NucleOCapsid Protein (His)	Virus	E. coli
	HCoV-OC43 Nucleoprotein (NP, N) is a homodimer with nonspecific binding activity toward nucleic acids. NP packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly, enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication through its interactions with the viral genome and membrane protein M. HCoV-OC43 Nucleoprotein/NP Protein (His) is the recombinant Virus-derived HCoV-OC43 Nucleoprotein/NP protein, expressed by E. coli , with N-His labeled tag. The total length of HCoV-OC43 Nucleoprotein/NP Protein (His) is 448 a.a., with molecular weight of ~50.43 KDa.

	*HCoV-OC43* Hemagglutinin esterase Protein (HEK293, His)** Human coronAvirus (HCoV-OC43) Hemagglutinin esterase Protein (His)	Virus	HEK293
	HCoV-OC43 is a type of coronavirus 1 that infects humans and cattle. HCoV-OC43 forms a spiky structural protein on the surface of the virus, contains receptor binding and receptor destruction activities, and mediates the deacetylation of n-acetyl-4-o-acetylneuraminic acid. HCoV-OC43 Hemagglutinin esterase Protein (HEK293, His) is the recombinant Virus-derived HCoV-OC43 Hemagglutinin esterase protein, expressed by HEK293 , with C-His labeled tag. The total length of HCoV-OC43 Hemagglutinin esterase Protein (HEK293, His) is 378 a.a., with molecular weight of ~44 KDa.

	*HCoV-OC43* Spike/S1 Protein (HEK293, His)** Human coronavirus (HCoV-OC43) Spike S1 Protein (His)	Virus	HEK293
	Coronaviruses, enveloped positive-strand RNA viruses, generally cause mild to moderate upper-respiratory tract illness. OC43, like SARS-CoV-2, is in the genus Betacoronavirus but grouped in another subgenus called Embecovirus. The NS2 protein of HCoV-OC43 has cyclic phosphodiesterase activity, which may modulate cAMP-mediated signaling and important physiological processes such as lipid metabolism and apoptosis. HCoV-OC43 replicate principally in the upper respiratory tract epithelial cells, where they produce virus and cause local respiratory symptoms. HCoV-OC43 Spike/S1 Protein (HEK293, His) is the recombinant Virus-derived HCoV-OC43 Spike/S1 protein, expressed by HEK293 , with C-His labeled tag. The total length of HCoV-OC43 Spike/S1 Protein (HEK293, His) is 794 a.a., with molecular weight of ~89.02 KDa.

	*HCoV-OC43* Spike/S2 Protein (AVR40344, sf9, His)** Human coronAvirus (HCoV-OC43) Spike S2 Protein (ECD, His)	Virus	Sf9 insect cells
	Coronaviruses, enveloped positive-strand RNA viruses, generally cause mild to moderate upper-respiratory tract illness. OC43, like SARS-CoV-2, is in the genus Betacoronavirus but grouped in another subgenus called Embecovirus. The NS2 protein of HCoV-OC43 has cyclic phosphodiesterase activity, which may modulate cAMP-mediated signaling and important physiological processes such as lipid metabolism and apoptosis. HCoV-OC43 replicate principally in the upper respiratory tract epithelial cells, where they produce virus and cause local respiratory symptoms. HCoV-OC43 Spike/S2 Protein (AVR40344, sf9, His) is the recombinant Virus-derived HCoV-OC43 Spike/S2 protein, expressed by Sf9 insect cells , with C-His labeled tag.

	*HCoV-OC43* Spike/S Protein (AVR40344, sf9, His)** Human coronAvirus (HCoV-OC43) Spike Protein (S1+S2 ECD, His)	Virus	Sf9 insect cells
	Coronaviruses, enveloped positive-strand RNA viruses, generally cause mild to moderate upper-respiratory tract illness. OC43, like SARS-CoV-2, is in the genus Betacoronavirus but grouped in another subgenus called Embecovirus. The NS2 protein of HCoV-OC43 has cyclic phosphodiesterase activity, which may modulate cAMP-mediated signaling and important physiological processes such as lipid metabolism and apoptosis. HCoV-OC43 replicate principally in the upper respiratory tract epithelial cells, where they produce virus and cause local respiratory symptoms. HCoV-OC43 Spike/S Protein (AVR40344, sf9, His) is the recombinant Virus-derived HCoV-OC43 Spike/S protein, expressed by Sf9 insect cells , with C-His labeled tag.

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