Search Result

Results for "

cytochrome-c

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cytochrome P450 (5) 5-HT Receptor (2) Akt (1) Apoptosis (26) Autophagy (6) Bacterial (1) Bcl-2 Family (4) Biochemical Assay Reagents (3) Calcium Channel (1) Caspase (9) DNA/RNA Synthesis (1) Dopamine Receptor (2) Endogenous Metabolite (4) Ferroptosis (1) Fungal (2) GABA Receptor (1) HDAC (1) Histone Methyltransferase (1) HIV (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) Lactate Dehydrogenase (2) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) Molecular Glues (1) Neurokinin Receptor (1) Oxidative Phosphorylation (4) P-glycoprotein (1) p38 MAPK (1) Parasite (1) PARP (1) PPAR (1) Reactive Oxygen Species (6) Sirtuin (1) Topoisomerase (1) TRP Channel (2)
By Research Areas:	Cancer (29) Cardiovascular Disease (4) Infection (3) Inflammation/Immunology (6) Metabolic Disease (8) Neurological Disease (5)

By Targets:

Cytochrome P450 (5)

5-HT Receptor (2)

Akt (1)

Apoptosis (26)

Autophagy (6)

Bacterial (1)

Bcl-2 Family (4)

Biochemical Assay Reagents (3)

Calcium Channel (1)

Caspase (9)

DNA/RNA Synthesis (1)

Dopamine Receptor (2)

Endogenous Metabolite (4)

Ferroptosis (1)

Fungal (2)

GABA Receptor (1)

HDAC (1)

Histone Methyltransferase (1)

HIV (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (2)

Lactate Dehydrogenase (2)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (2)

Molecular Glues (1)

Neurokinin Receptor (1)

Oxidative Phosphorylation (4)

P-glycoprotein (1)

p38 MAPK (1)

Parasite (1)

PARP (1)

PPAR (1)

Reactive Oxygen Species (6)

Sirtuin (1)

Topoisomerase (1)

TRP Channel (2)

By Research Areas:

Cancer (29)

Cardiovascular Disease (4)

Infection (3)

Inflammation/Immunology (6)

Metabolic Disease (8)

Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Cytochrome P450

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125857

*Cytochrome C*	Biochemical Assay Reagents Apoptosis Reactive Oxygen Species	Metabolic Disease
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis .

HY-W012568

1-Methoxynaphthalene	Others	Others
1-Methoxynaphthalene is used as the substrate to investigate the activity of cytochrome c peroxidase (CcP). 1-Methoxynaphthalene also can be used to synthesize prenyl naphthalen-ols .

HY-14804

Tasisulam LY 573636	Molecular Glues Apoptosis	Cancer
Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization .

HY-103349

PETCM 1 Publications Verification	Caspase Apoptosis	Cancer
PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells .

HY-U00448

ADDA 5 hydrochloride 2 Publications Verification	Others	Cancer
ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO), with IC₅₀s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively.

HY-N10191

Hydroaurantiogliocladin	Others	Metabolic Disease
Hydroaurantiogliocladin is a quinol. Hydroaurantiogliocladin can be used as substrate for the quinol-cytochrome c oxidoreductase activity (beef heart enzyme) .

HY-103272

iMAC2	Apoptosis Bacterial	Others
iMAC2 is a potent MAC inhibitor with an IC₅₀ of 28 nM and an LD₅₀ of 15000 nM. iMAC2 shows anti-apoptotic effect. iMAC2 blocks cytochrome c release .

HY-129715

MPI-0441138	Apoptosis	Cancer
MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death .

HY-14804A

Tasisulam sodium LY 573636 sodium	Apoptosis	Cancer
Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization .

HY-W011254

Ac-VAD-CHO Ac-Val-Ala-Asp-CHO	Caspase	Cancer
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells .

HY-110073

iMAC2 hydrochloride	Apoptosis	Inflammation/Immunology Cancer
iMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an IC₅₀ of 28 nM and a LD₅₀ of 15000 nM. iMAC2 hydrochloride shows anti-apoptotic effect. iMAC2 hydrochloride blocks cytochrome c release .

HY-W011978

N-Acetyl-L-tryptophan	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related	Neurological Disease Inflammation/Immunology
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-P3586

HKPao Hunter-killer peptide ao; Prohibitin-targeting peptide 1; prohibitin-TP01; Adipotide	Apoptosis	Cancer
HKPao (Hunter-killer peptide ao) is a biologically active peptide. HKPao (Hunter-killer peptide ao) has anti-obesity and anti-tumor pro-apoptotic activity to cause release of cytochrome c from vesicles .

HY-156136

5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole	Biochemical Assay Reagents	Others
5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole is a competitive Q_o site inhibitor of the cytochrome bc 1 complex (cytochrome c oxidoreductase) from Saccharomyces cerevisiae .

HY-W009048

Dicyclohexano-18-crown-6-ether DCH18C6; Perhydrodibenzo-18-crown-6	Biochemical Assay Reagents	Others
Dicyclohexano-18-crown-6-ether selectively extracts lysine-rich cytochrome c proteins from other cationic proteins under weakly acidic and neutral conditions, demonstrating specificity in ligand-protein interactions .

HY-118452

cis-3,4',5-Trimethoxy-3'-hydroxystilbene	Microtubule/Tubulin Apoptosis	Cancer
cis-3,4',5-Trimethoxy-3'-hydroxystilbene is a stilbene. cis-3,4',5-Trimethoxy-3'-hydroxystilbene induces *cytochrome c* release to the cytoplasm. cis-3,4',5-Trimethoxy-3'-hydroxystilbene-induced apoptosis is associated with mitochondrial release of cytochrome c. cis-3,4',5-Trimethoxy-3'-hydroxystilbene also suppresses tubulin polymerization. cis-3,4',5-Trimethoxy-3'-hydroxystilbene can be used for leukemic research .

HY-N2374

Eupatorin	Apoptosis	Cancer
Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-N12443

Antioxidant agent-18	Others	Inflammation/Immunology
Antioxidant agent-18 (compound 5) is a flavonol glycoside with antioxidant activity isolated from Ginkgo biloba. Antioxidant agent-18 scavenges DPPH radicals (IC₅₀: 15.8 μM) and reduces cytochrome c (IC₅₀: 14.7 μM).

HY-122481

Thaspine acetate	Topoisomerase Apoptosis Bcl-2 Family Cytochrome P450	Cancer
Thaspine acetate, an alkaloid, is a topoisomerase I and II inhibitor. Thaspine acetate induces cancer cell apoptosis. Thaspine acetate induces Bak and Bax activation, mitochondrial cytochrome c release and mitochondrial membrane permeabilization. Thaspine acetate can be isoalted from the cortex of the South American tree Croton lechleri .

HY-122652

MitoBloCK-6	Apoptosis	Metabolic Disease
MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC₅₀ of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC₅₀=1.4 μM). MitoBloCK-6 can induce apoptosis via cytochrome c release in hESCs .

HY-10448

Capsaicin 35+ Cited Publications (E)-Capsaicin	TRP Channel Autophagy Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain-relieving, antioxidant, anti-inflammatory, anti-cancer and certain neurotoxic effects .

HY-10448S4

Capsaicin-d7 (E)-Capsaicin-d₇	TRP Channel Autophagy Endogenous Metabolite Apoptosis Isotope-Labeled Compounds	Cancer
Capsaicin-d₇ is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects .

HY-B0831

Buprofezin	Oxidative Phosphorylation Reactive Oxygen Species	Others
Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase .

HY-N2374R

Eupatorin (Standard)	Apoptosis	Cancer
Eupatorin (Standard) is the analytical standard of Eupatorin. This product is intended for research and analytical applications. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-B0831S

Buprofezin-d6	Oxidative Phosphorylation Reactive Oxygen Species	Metabolic Disease
Buprofezin-d₆ is the deuterium labeled Buprofezin. Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase[1][2].

HY-125018

QM31 SVT016426	Caspase	Cancer
QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC₅₀=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint .

HY-B0831R

Buprofezin (Standard)	Oxidative Phosphorylation Reactive Oxygen Species	Others
Buprofezin (Standard) is the analytical standard of Buprofezin. This product is intended for research and analytical applications. Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase .

HY-119682

Bax agonist 1	Bcl-2 Family Apoptosis	Cancer
Bax agonist 1 (compound SMBA2) is a Bax agonist (K_i=57.2 nM). Bax agonist 1 induces Bax conformational changes by blocking S184 phosphorylation, promoting Bax insertion into the mitochondrial membrane and forming Bax oligomers, which induce cytochrome c release and apoptosis in malignant cancer cells expressing Bax. Bax agonist 1 can be used in lung cancer research .

HY-131503

13-Methyltetradecanoic acid 13-MTD; 13-Methylmyristic acid	Apoptosis	Cancer
13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-148368

CYD-4-61	Bcl-2 Family Apoptosis	Cancer
CYD-4-61 is a novel Bax activator used for breast cancer research. CYD-4-61 inhibits triple-negative breast cancer MDA-MB-231 and ER-positive breast cancer MCF-7 cell lines proliferation. CYD-4-61 activates Bax protein to induce cytochrome c release and regulate apoptotic biomarkers, leading to cancer cell apoptosis .

HY-B0854

Mancozeb	Fungal Keap1-Nrf2 Apoptosis Lactate Dehydrogenase Cytochrome P450	Infection Metabolic Disease Cancer
Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and *cytochrome c* to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells .

HY-W012145

TMPD dihydrochloride	Others	Metabolic Disease
TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases . TMPD dihydrochloride is also a complex IV substrate .

HY-13653S

(+/-)-Epigallocatechin Gallate-13C3	Oxidative Phosphorylation Autophagy Reactive Oxygen Species HIV Ferroptosis Mitochondrial Metabolism Endogenous Metabolite	Cancer
(+/-)-Epigallocatechin Gallate- ¹³C₃ is the ¹³C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects[1]. (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation (OXPHOS) by activating cytochrome c oxidase.

HY-111329

JGB1741 ILS-JGB-1741	Sirtuin Apoptosis	Cancer
JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC₅₀ of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC₅₀>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research .

HY-121746

GW7845	PPAR Calcium Channel Apoptosis	Cardiovascular Disease Metabolic Disease
GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC₅₀ of 3 μM by using Ba ²⁺ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells .

HY-B0854R

Mancozeb (Standard)	Fungal Keap1-Nrf2 Apoptosis Lactate Dehydrogenase Cytochrome P450	Infection Metabolic Disease Cancer
Mancozeb (Standard) is the analytical standard of Mancozeb. This product is intended for research and analytical applications. Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and *cytochrome c* to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells.

HY-B0837

Emamectin Benzoate MK-244	Parasite GABA Receptor Reactive Oxygen Species Apoptosis	Infection Neurological Disease
Emamectin Benzoate (MK-244) is an orally active nervoussystem toxicant by binding g-aminobutyric (GABA) receptor in insects. Emamectin Benzoate is one of semi-synthetic derivative of Avermectin (HY-15311) with a broadspectrum of insecticidal and acaricidal activity. Emamectin Benzoate induces ROS-mediated DNA damage and cell apoptosis. Emamectin Benzoate, a mixture of the natural Emamectin B1a benzoate and Emamectin B1b benzoate, has the main component of Emamectin B1a benzoate .

HY-13610

N1,N11-Diethylnorspermine	Caspase	Cancer
N1,N11-Diethylnorspermine (DENSPM) is a potent anticancer agent. N1,N11-Diethylnorspermine is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .

HY-N3584

Paris saponin VII 2 Publications Verification Chonglou Saponin VII	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis	Cancer
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-13610B

N1,N11-Diethylnorspermine hydrobromide	Caspase	Cancer
N1,N11-Diethylnorspermine hydrobromide is a potent anticancer agent. N1,N11-Diethylnorspermine hydrobromide is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine hydrobromide induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine hydrobromide kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .

HY-130326

RAPTA-C Ru(η6-p-cymene)Cl2(pta)	Apoptosis Caspase	Cardiovascular Disease Cancer
RAPTA-C (Ru(η6-p-cymene)Cl2(pta)) acts as an anti-cancer and anti-angiogenic agent. RAPTA-C exhibits anti-metastatic, anti-angiogenic, and anti-tumoral activities through protein and histone-deoxyribonucleic acid alterations. RAPTA-C exhibits cell growth inhibition by triggering G(2)/M phase arrest in cancer cells. RAPTA-C also enhances the levels of p53 and triggers the mitochondrial Apoptotic pathway, resulting in cytochrome C release and caspase-9 activation. RAPTA-C reduces the growth of tumors with the inhibition of angiogenesis in a ovarian carcinoma model .

HY-156096

HDAC3-IN-2	HDAC Histone Methyltransferase Caspase Apoptosis DNA/RNA Synthesis	Cancer
HDAC3-IN-2 (compound 4i) is a pyrazinyl hydrazide-based HDAC3 inhibitor (IC₅₀: 14 nM) that efficiently targets triple-negative breast cancer cells. HDAC3-IN-2 is cytotoxic with an IC₅₀ of 0.55 μM against 4T1 and an IC₅₀ of 0.74 μM against MDA-MB-231. HDAC3-IN-2 has anti-tumor efficacy in vivo in tumor-bearing mouse models, selectively increasing the acetylation levels of H3K9, H3K27 and H4K12, increasing the contents of apoptosis-related caspase-3, caspase-7 and cytochrome c, and reducing Proliferation-related Bcl-2, CD44, EGFR, and Ki-67 levels .

HY-12708

Chlorpromazine Maximum Cited Publications 57 Publications Verification	Dopamine Receptor Cytochrome P450 Autophagy 5-HT Receptor	Cardiovascular Disease Neurological Disease Cancer
Chlorpromazine is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT_2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine also blocks hNa_v1.7 channels (IC₅₀=25.9 μM; concentration-dependent) and HERG potassium channels (IC₅₀=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine also can inhibit clathrin-mediated endocytosis .

HY-B0407A

Chlorpromazine hydrochloride Maximum Cited Publications 57 Publications Verification	Dopamine Receptor Autophagy Cytochrome P450 5-HT Receptor	Cardiovascular Disease Neurological Disease Cancer
Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT_2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNa_v1.7 channels (IC₅₀=25.9 μM; concentration-dependent) and HERG potassium channels (IC₅₀=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .

Cat. No.	Product Name

HY-L144

Mitochondrial Protection Compound Library	620 compounds
Normal mitochondrial function is critical for maintaining cellular homeostasis because mitochondria produce ATP and are the major intracellular source of free radicals. Cellular dysfunctions induced by intracellular or extracellular insults converge on mitochondria and induce a sudden increase in permeability on the inner mitochondrial membrane, the so-called mitochondrial membrane permeability transition (MMPT). MMPT is caused by the opening of pores in the inner mitochondrial membrane, matrix swelling, and outer membrane rupture. The MMPT is an endpoint to initiate cell death because the pore opening together with the release of mitochondrial cytochrome c activates the apoptotic pathway of caspases. The normal operation of mitochondrial function is important for maintaining normal cell death and treatment of mitochondrial diseases. MCE offers a unique collection of 620 compounds with identified and potential mitochondrial protective activity. MCE Mitochondrial Protection Compound Library is critical for drug discovery and development.

Mitochondrial Protection Compound Library

620 compounds

Normal mitochondrial function is critical for maintaining cellular homeostasis because mitochondria produce ATP and are the major intracellular source of free radicals. Cellular dysfunctions induced by intracellular or extracellular insults converge on mitochondria and induce a sudden increase in permeability on the inner mitochondrial membrane, the so-called mitochondrial membrane permeability transition (MMPT). MMPT is caused by the opening of pores in the inner mitochondrial membrane, matrix swelling, and outer membrane rupture. The MMPT is an endpoint to initiate cell death because the pore opening together with the release of mitochondrial cytochrome c activates the apoptotic pathway of caspases.

The normal operation of mitochondrial function is important for maintaining normal cell death and treatment of mitochondrial diseases. MCE offers a unique collection of 620 compounds with identified and potential mitochondrial protective activity. MCE Mitochondrial Protection Compound Library is critical for drug discovery and development.

Cat. No.	Product Name	Type

HY-125857

*Cytochrome C*	Cell Assay Reagents
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis .

HY-W009048

Dicyclohexano-18-crown-6-ether DCH18C6; Perhydrodibenzo-18-crown-6	Chelators
Dicyclohexano-18-crown-6-ether selectively extracts lysine-rich cytochrome c proteins from other cationic proteins under weakly acidic and neutral conditions, demonstrating specificity in ligand-protein interactions .

Cat. No.	Product Name	Target	Research Area

HY-P1089

Cytochrome c-pigeon (88-104) PCC 88-104	Peptides	Inflammation/Immunology
Cytochrome c-pigeon (88-104) (PCC 88-104) has full stimulatory activity for pigeon cytochrome c-primed T cells from B10.A mice. The I-E ^k-restricted T cell response to Cytochrome c pigeon (pcyt c) is specific for the COOH-terminal sequence 88-104 .

HY-P1735

*Moth Cytochrome C* (MCC) (88-103)**	Peptides	Inflammation/Immunology
Moth Cytochrome C (MCC) (88-103), derived from the carboxyl terminus of moth cytochrome c, induces positive selection of TCR transgenic thymocytes .

HY-W011254

Ac-VAD-CHO Ac-Val-Ala-Asp-CHO	Caspase	Cancer
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells .

HY-P3586

HKPao Hunter-killer peptide ao; Prohibitin-targeting peptide 1; prohibitin-TP01; Adipotide	Apoptosis	Cancer
HKPao (Hunter-killer peptide ao) is a biologically active peptide. HKPao (Hunter-killer peptide ao) has anti-obesity and anti-tumor pro-apoptotic activity to cause release of cytochrome c from vesicles .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W011978

N-Acetyl-L-tryptophan	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-N2374

Eupatorin	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Source classification Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Cancer	Apoptosis
Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-10448

Capsaicin 35+ Cited Publications (E)-Capsaicin	Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Solanaceae Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain-relieving, antioxidant, anti-inflammatory, anti-cancer and certain neurotoxic effects .

HY-131503

13-Methyltetradecanoic acid 13-MTD; 13-Methylmyristic acid	Classification of Application Fields Leguminosae Glycine max (L.) merr Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	Apoptosis
13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-N3584

Paris saponin VII 2 Publications Verification Chonglou Saponin VII	Structural Classification Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N10191

Hydroaurantiogliocladin	Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Disease Research Fields	Others
Hydroaurantiogliocladin is a quinol. Hydroaurantiogliocladin can be used as substrate for the quinol-cytochrome c oxidoreductase activity (beef heart enzyme) .

HY-N12443

Antioxidant agent-18	Structural Classification Ginkgoaceae Source classification Phenols Polyphenols Plants Ginkgo biloba	Others
Antioxidant agent-18 (compound 5) is a flavonol glycoside with antioxidant activity isolated from Ginkgo biloba. Antioxidant agent-18 scavenges DPPH radicals (IC₅₀: 15.8 μM) and reduces cytochrome c (IC₅₀: 14.7 μM).

HY-N2374R

Eupatorin (Standard)	Structural Classification Flavonoids Classification of Application Fields Cruciferae Source classification Phenols Isatis tinctoria L. Plants Disease Research Fields Cancer	Apoptosis
Eupatorin (Standard) is the analytical standard of Eupatorin. This product is intended for research and analytical applications. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

Species:	Human (5)
Tag:	His (4) SUMO (1) GST (1)
Source:	E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P70053

	Cytochrome c/CYCS Protein, Human (His) rHucytochrome c/CYCS, His; cytochrome C; CYCS; CYC	Human	E. coli
	Cytochrome c is an electron carrier protein that accepts electrons from cytochrome c1 and transfers them to the cytochrome oxidase complex in the mitochondrial electron transport chain. It is involved in apoptosis, where the release of cytochrome c into the cytosol leads to caspase-9 activation and subsequent acceleration of apoptosis. Cytochrome c/CYCS Protein, Human (His) is the recombinant human-derived Cytochrome c/CYCS protein, expressed by E. coli , with C-6*His labeled tag. The total length of Cytochrome c/CYCS Protein, Human (His) is 104 a.a., with molecular weight of ~16.0 kDa.

HY-P75686

	COX5B Protein, Human (His) cytochrome c oxidase subunit 5B, mitochondrial; COX5B	Human	E. coli
	The COX5B protein is a component of cytochrome c oxidase, the final enzyme in the mitochondrial electron transport chain. COX5B Protein, Human (His) is the recombinant human-derived COX5B protein, expressed by E. coli , with N-His labeled tag. The total length of COX5B Protein, Human (His) is 98 a.a., with molecular weight of ~14 kDa.

HY-P71088

	UQCRH Protein, Human (GST) cytochrome b-c1 complex subunit 6; mitochondrial; Complex III subunit 6; Complex III subunit VIII; cytochrome c1 non-heme 11 kDa protein; Mitochondrial hinge protein; Ubiquinol-cytochrome c reductase complex 11 kDa protein	Human	E. coli
	UQCRH is an important component of the mitochondrial electron transport chain and contributes to oxidative phosphorylation within the ubiquinol-cytochrome c oxidoreductase complex. It operates in the respiratory chain, transferring electrons from NADH and succinate to molecular oxygen, establishing an electrochemical gradient for ATP synthesis. UQCRH Protein, Human (GST) is the recombinant human-derived UQCRH protein, expressed by E. coli , with N-GST labeled tag. The total length of UQCRH Protein, Human (GST) is 91 a.a., with molecular weight of 33-45 kDa.

HY-P70211

	GGCT Protein, Human (His) rHuGamma-glutamylcyclotransferase/GGCT, His; Gamma-Glutamylcyclotransferase; cytochrome C-Releasing Factor 21; GGCT; C7orf24; CRF21	Human	E. coli
	The GGCT protein is a key player in sulfate assimilation, catalyzing the initial step in the conversion of inorganic sulfate and ATP to adenosine-5'-phosphate sulfate (APS). This activity is essential for the biosynthesis of sulfur-containing amino acids and is essential for cellular sulfur metabolism. GGCT Protein, Human (His) is the recombinant human-derived GGCT protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72150

	COX4I1 Protein, Human (His-SUMO) AL024441; COX 4; COX IV 1; COX IV; COX IV-1; Cox4; COX41_HUMAN; Cox4a; COX4B; COX4I1; COX4I2; COX4L2; COXIV; cytochrome c oxidase polypeptide IV; cytochrome c oxidase subunit 4 isoform 1 mitochondrial; cytochrome c oxidase subunit 4 isoform 1, mitochondrial; cytochrome C Oxidase subunit IV; cytochrome c oxidase subunit IV isoform 1; cytochrome c oxidase subunit IV isoform 2 lung; ; cytochrome c oxydase subunit 4; dJ857M17.2; MGC105470; MGC72016	Human	E. coli
	The COX4I1 protein is a component of cytochrome c oxidase, the final enzyme in the mitochondrial electron transport chain responsible for oxidative phosphorylation. COX4I1 Protein, Human (His-SUMO) is the recombinant human-derived COX4I1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of COX4I1 Protein, Human (His-SUMO) is 147 a.a., with molecular weight of ~33.2 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-10448S4

Capsaicin-d7
Capsaicin-d₇ is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects .

HY-B0831S

Buprofezin-d6

Buprofezin-d₆ is the deuterium labeled Buprofezin. Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase[1][2].

HY-13653S

(+/-)-Epigallocatechin Gallate-13C3

(+/-)-Epigallocatechin Gallate- ¹³C₃ is the ¹³C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects[1]. (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation (OXPHOS) by activating cytochrome c oxidase.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80102

	Cytochrome C Antibody	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
	Cytochrome C Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 12 kDa, targeting to Cytochrome C. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P83509

	MTCO2 Antibody (YA3254) MT-CO2; COX2; CO2; cytochrome c oxidase II; MTCO2; COII; COXII	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	MTCO2 Antibody (YA3254) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3254), targeting MTCO2, with a predicted molecular weight of 26 kDa (observed band size: 21 kDa). MTCO2 Antibody (YA3254) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

HY-P82866

	Cytochrome C Oxidase subunit Vic Antibody (YA2611) cytochrome c oxidase subunit 6C	WB, IHC-P	Human, Mouse, Rat
	Cytochrome C Oxidase subunit Vic Antibody (YA2611) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2611), targeting Cytochrome C Oxidase subunit Vic, with a predicted molecular weight of 9 kDa (observed band size: 12 kDa). Cytochrome C Oxidase subunit Vic Antibody (YA2611) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P82805

	COX5B Antibody (YA2550) COX5B; cytochrome c oxidase subunit 5B; mitochondrial; cytochrome c oxidase polypeptide Vb	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	COX5B Antibody (YA2550) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2550), targeting COX5B, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). COX5B Antibody (YA2550) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P82184

	Complex III Subunit 2 Antibody (YA1929) Core protein II; QCR2; mitochondrial; Ubiquinol cytochrome c reductase core protein II; UQCR2; Uqcrc2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Complex III Subunit 2 Antibody (YA1929) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1929), targeting Complex III Subunit 2, with a predicted molecular weight of 48 kDa (observed band size: 48 kDa). Complex III Subunit 2 Antibody (YA1929) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.