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dopamine beta-hydroxylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine β-hydroxylase (14) Antibiotic (2) Apoptosis (2) Aryl Hydrocarbon Receptor (1) Bacterial (1) BCRP (1) Cytochrome P450 (2) Endogenous Metabolite (1) Fungal (1) Influenza Virus (2) Monoamine Oxidase (2) P-glycoprotein (1) Phosphatase (1) PKC (2) Reverse Transcriptase (2) Telomerase (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (9) Infection (5) Metabolic Disease (2) Neurological Disease (3)

16

Inhibitors & Agonists

5

Natural
Products

1

Recombinant Proteins

Targets Recommended: Dopamine β-hydroxylase Dopamine Receptor Tryptophan Hydroxylase Dopamine Transporter HIF/HIF Prolyl-Hydroxylase Amyloid-β TGF-β Receptor Beta-secretase β-glucuronidase TGF-beta/Smad 17β-HSD β-catenin 11β-HSD Beta-lactamase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Guanoclor Vatensol	Dopamine β-hydroxylase	Cardiovascular Disease
Guanoclor is an antihypertensive compound. Guanoclor is an adrenergic neurone-blocking agent, which also interferes with noradrenaline synthesis by inhibition of the enzyme dopamine beta-hydroxylase .

U-14624	Dopamine β-hydroxylase	Neurological Disease
U-14624 is a potent and orally active **dopamine beta-hydroxylase** inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes .

Fusaric acid	Dopamine β-hydroxylase	Infection
Fusaric acid is a potent **dopamine β-hydroxylase** inhibitor.

Nepicastat hydrochloride 3 Publications Verification SYN-117 hydrochloride; RS-25560-197 hydrochloride	Dopamine β-hydroxylase	Cardiovascular Disease
Nepicastat hydrochloride (SYN-117 hydrochloride) is a selective, potent, and orally active inhibitor of *dopamine-beta-hydroxylase. Nepicastat hydrochloride produces concentration-dependent inhibition of bovine (IC₅₀=8.5 nM) and human (IC₅₀=9 nM) dopamine-beta-hydroxylase*. Nepicastat hydrochloride can cross the blood-brain barrier (BBB) .

Etamicastat hydrochloride BIA 5-453 hydrochloride	Dopamine β-hydroxylase	Cardiovascular Disease
Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible *dopamine-β-hydroxylase* (DBH) inhibitor with an IC₅₀ value of 107 nM . Etamicastat can be used in the research of cardiovascular diseases .

Oosponol	Dopamine β-hydroxylase Fungal	Infection Cardiovascular Disease
Oosponol is a **dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi** .

Dopastin	Others	Others
Dopastin is a compound that inhibits dopamine β-hydroxylase.

Nepicastat SYN117; RS-25560-197	Dopamine β-hydroxylase	Cardiovascular Disease
Nepicastat (SYN117) is a selective, potent, and orally active inhibitor of *dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC₅₀=8.5 nM) and human (IC₅₀=9 nM) dopamine-beta-hydroxylase*. Nepicastat (SYN117) can cross the blood-brain barrier (BBB) .

(R)-Nepicastat hydrochloride (R)-SYN117 hydrochloride; (R)-RS-25560-197 hydrochloride; RS-25560-198 hydrochloride	Dopamine β-hydroxylase	Cardiovascular Disease
(R)-Nepicastat hydrochloride is the isomer of Nepicastat (HY-13289). Nepicastat (SYN117) is a selective，potent，and orally active inhibitor of *dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC₅₀=8.5 nM) and human (IC₅₀=9 nM) dopamine-beta-hydroxylase*. Nepicastat (SYN117) can cross the blood-brain barrier (BBB) .

Etamicastat BIA 5-453	Dopamine β-hydroxylase	Cardiovascular Disease
Etamicastat (BIA 5-453) is a potent and reversible *dopamine-β-hydroxylase* (DBH) inhibitor with an IC₅₀ value of 107 nM . Etamicastat can be used in the research of cardiovascular diseases .

2-Mercaptobenzothiazole	Endogenous Metabolite Aryl Hydrocarbon Receptor	Metabolic Disease
2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR) , inhibiting thyroid hormone synthesis and dopamine beta-hydroxylase activity . 2-Mercaptobenzothiazole promotes bladder cancer cell invasion by altering the conformation of the AhR ligand binding domain (LBD), activating AhR transcription, and upregulating the mRNA and protein expression of target genes CYP1A1 and CYP1B1 . 2-Mercaptobenzothiazole inhibits thyroid peroxidase (TPO) with an IC₅₀ value of 11.5 μM, induces histological changes such as follicular cell hypertrophy in Xenopus laevis tadpoles, delaying metamorphosis . 2-Mercaptobenzothiazole increases chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, and enhances carcinogenicity in F344/N rats . 2-Mercaptobenzothiazole inhibits norepinephrine synthesis in mice and completely blocks the conversion of exogenous dopamine to norepinephrine in rat cardiomyocytes .

A32390A	Dopamine β-hydroxylase Bacterial	Infection Cardiovascular Disease Metabolic Disease
A32390A is a **dopamine β-hydroxylase inhibitor and copper chelator. A32390A can inhibit the synthesis of norepinephrine, which helps lower blood pressure in DOCA hypertensive rats. A32390A can be used in research on hypertension, bacterial** infections, and metabolic disorders .

Hypericin 3 Publications Verification	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase	Infection Neurological Disease Cancer
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), *dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450*). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

EWP 815	Phosphatase Dopamine β-hydroxylase	Others
EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4)P₂ phosphatase and Ins(1,4,5)P₃ 5-phosphatase. EWP 815 also inhibits enzyme **dopamine β-hydroxylase** activity .

Hypericin (Standard) 3 Publications Verification	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase	Infection Neurological Disease Cancer
Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), *dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450*). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

Zamicastat BIA 5-1058	Dopamine β-hydroxylase P-glycoprotein BCRP	Cardiovascular Disease Cancer
Zamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC₅₀ values of 73.8 μM and 17.0 μM, respectively . Zamicastat reduces high blood pressure .

Cat. No.	Compare	Product Name	Species	Source

	Dopamine beta-Hydroxylase Protein, Human (HEK293, His) dopamine beta-hydroxylase; DBH; DOPBHY	Human	HEK293
	Dopamine beta-hydroxylase protein is an essential enzyme involved in the regulation of neurotransmitters. Its main function is to catalyze the hydroxylation of dopamine, converting it into norepinephrine (also known as norepinephrine). Dopamine beta-Hydroxylase Protein, Human (HEK293, His) is the recombinant human-derived Dopamine beta-Hydroxylase protein, expressed by HEK293 , with N-His labeled tag. The total length of Dopamine beta-Hydroxylase Protein, Human (HEK293, His) is 578 a.a., with molecular weight of ~68 kDa.

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