endocytosis blocker

By Targets:	5-HT Receptor (2) Apoptosis (1) Arrestin (1) Autophagy (3) Biochemical Assay Reagents (1) Cytochrome P450 (2) Dopamine Receptor (2) Dynamin (4) iGluR (1) Influenza Virus (2) PIKfyve (1) SARS-CoV (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (5) Inflammation/Immunology (1) Neurological Disease (7)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1083

Dynamin inhibitory peptide 1 Publications Verification	Dynamin	Neurological Disease
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors .

HY-D1027

Dansylcadaverine 5+ Cited Publications Monodansyl cadaverine	Autophagy	Others
Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands .

HY-P2259

TAT-GluA2 3Y 1 Publications Verification	iGluR	Neurological Disease
TAT-GluA2 3Y, an interference peptide, blocks long-term depression (LTD) at glutamatergic synapses by disrupting the endocytosis of AMPAR. TAT-GluA2 3Y can alleviate Pentobarbital-induced spatial memory deficits and synaptic depression .

HY-N6025

Clemastanin B	Influenza Virus	Infection Inflammation/Immunology
Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities .

HY-101461

Methyl-β-cyclodextrin 45+ Cited Publications Methyl-beta-cyclodextrin	Biochemical Assay Reagents	Cancer
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent . Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis . Methyl-β-cyclodextrin blocks cell migrasome formation .

HY-164290

Rhodady C10	Dynamin	Infection Neurological Disease
Rhodady C10 (Compound C10) is a dynamin I GTPase inhibitor. Rhodady C10 blocks receptor-mediated endocytosis (IC₅₀: 7 μM). Dynamin is involved in clathrin-independent endocytosis, phagocytosis, and caveolae internalization .

HY-P1083A

Dynamin inhibitory peptide TFA	Dynamin	Neurological Disease
Dynamin inhibitory peptide TFA competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide TFA blocks the dopamine D₃ effect on GABA_A receptors .

HY-158097

IAV-IN-2	Influenza Virus	Infection
IAV-IN-2 (Compound MC-22) inhibits for Influenza A Virus (IAV) through blocking the entry of IAV into host cell via clathrin-mediated endocytosis (CME) .

HY-152216

Dynamin IN-2	Dynamin	Neurological Disease
Dynamin IN-2 (compound 43), a Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC₅₀ of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated *endocytosis* (CME), with an IC₅₀ of 9.5 μM .

HY-115513

Pitstop 1	Others	Infection
Pitstop 1 is a small molecule inhibitor with endocytosis-inhibiting activity. Pitstop 1 blocks the interaction of chaperones with the Krasin terminal domain in cells, thereby affecting the function of Krasin. Pitstop 1 exhibits superior biological activity in significantly inhibiting the effects of Krasin. Pitstop 1 acts as a dose that inhibits the entry of viruses and pathogens into cells and modulates cell signaling .

HY-119706

Barbadin 5+ Cited Publications	Apoptosis Arrestin	Others
Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC₅₀ values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis .

HY-163943

UNI418	SARS-CoV PIKfyve	Infection
UNI418 is a dual inhibitor of PIKfyve and PIP5K1C with antiviral activity against SARS-CoV-2 (EC₅₀=1.4 μM). UNI418 blocks ACE2-mediated SARS-CoV-2 viral endocytosis by inhibiting PIP5K1C (IC₅₀=60.1 nM; K_d=61 nM). In addition, UNI418 inhibits the proteolytic activation of proteases regulated by PIKfyve (K_d=0.78 nM) to prevent SARS-CoV-2 from entering host cells .

HY-12708

Chlorpromazine Maximum Cited Publications 57 Publications Verification	Dopamine Receptor Cytochrome P450 Autophagy 5-HT Receptor	Cardiovascular Disease Neurological Disease Cancer
Chlorpromazine is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT_2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine also blocks hNa_v1.7 channels (IC₅₀=25.9 μM; concentration-dependent) and HERG potassium channels (IC₅₀=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine also can inhibit clathrin-mediated endocytosis .

HY-B0407A

Chlorpromazine hydrochloride Maximum Cited Publications 57 Publications Verification	Dopamine Receptor Autophagy Cytochrome P450 5-HT Receptor	Cardiovascular Disease Neurological Disease Cancer
Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT_2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNa_v1.7 channels (IC₅₀=25.9 μM; concentration-dependent) and HERG potassium channels (IC₅₀=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .

Cat. No.	Product Name	Type

HY-D1027

Dansylcadaverine 5+ Cited Publications Monodansyl cadaverine	Fluorescent Dyes/Probes
Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands .

Cat. No.	Product Name	Type

HY-101461

Methyl-β-cyclodextrin 45+ Cited Publications Methyl-beta-cyclodextrin	Co-solvents
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent . Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis . Methyl-β-cyclodextrin blocks cell migrasome formation .

Cat. No.	Product Name	Target	Research Area

HY-P1083

Dynamin inhibitory peptide 1 Publications Verification	Dynamin	Neurological Disease
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors .

HY-P2259

TAT-GluA2 3Y 1 Publications Verification	iGluR	Neurological Disease
TAT-GluA2 3Y, an interference peptide, blocks long-term depression (LTD) at glutamatergic synapses by disrupting the endocytosis of AMPAR. TAT-GluA2 3Y can alleviate Pentobarbital-induced spatial memory deficits and synaptic depression .

HY-P1083A

Dynamin inhibitory peptide TFA	Dynamin	Neurological Disease
Dynamin inhibitory peptide TFA competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide TFA blocks the dopamine D₃ effect on GABA_A receptors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6025

Clemastanin B	Structural Classification Classification of Application Fields Cruciferae Source classification Lignans Isatis tinctoria L. Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Influenza Virus
Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities .

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endocytosis blocker

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