Search Result

Results for "

gap

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Gap Junction Protein (19) 11β-HSD (2) 5-HT Receptor (2) Amyloid-β (1) Antibiotic (3) Apoptosis (2) Bacterial (3) Biochemical Assay Reagents (1) Calcium Channel (1) Cannabinoid Receptor (1) Caspase (1) Endogenous Metabolite (9) Fat Mass and Obesity-associated Protein (FTO) (4) Fluorescent Dye (6) GnRH Receptor (3) HDAC (1) HIV (1) Isotope-Labeled Compounds (2) Keap1-Nrf2 (1) Liposome (1) Orthopoxvirus (1) Potassium Channel (2) Ras (1) Reactive Oxygen Species (1) Reverse Transcriptase (1) RGS Protein (1) Small Interfering RNA (siRNA) (5) Topoisomerase (3)
By Research Areas:	Cancer (6) Cardiovascular Disease (10) Endocrinology (3) Infection (5) Inflammation/Immunology (13) Metabolic Disease (6) Neurological Disease (9)
Oligonucleotides:	Pre-designed siRNA Sets (5) Phospholipids (1) siRNAs (5)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Gap Junction Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0139

Gap 27 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment .

HY-P1082

Gap 26 5+ Cited Publications	Gap Junction Protein	Cardiovascular Disease
Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-P1082A

Gap 26 TFA 5+ Cited Publications	Gap Junction Protein	Cardiovascular Disease
Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-P1136A

Gap19 TFA 4 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .

HY-10913A

Danegaptide Hydrochloride 1 Publications Verification gap-134 Hydrochloride; ZP 1609 Hydrochloride	Gap Junction Protein	Cardiovascular Disease
Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active *gap-junction* modifier with an antiarrhythmic effect .

HY-P3606

GnRH Associated Peptide (1-24), human gap (1-24), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-P3605

GnRH Associated Peptide (25-53), human gap (25-53), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-P1136

Gap19	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .

HY-10913

Danegaptide gap-134; ZP 1609	Gap Junction Protein	Cardiovascular Disease
Danegaptide (GAP-134) is a potent, selective and orally active *gap-junction* modifier with an antiarrhythmic effect .

HY-RS05272

GAP43 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GAP43 Human Pre-designed siRNA Set A contains three designed siRNAs for GAP43 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GAP43 Human Pre-designed siRNA Set A GAP43 Human Pre-designed siRNA Set A

HY-P1136B

*TAT-Gap19*	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-P1136C

*TAT-Gap19 TFA*	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19 TFA, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 TFA does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 TFA traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-P1174

*GnRH Associated Peptide (GAP) (1-13), human*	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-13), human is an amino acid peptide fragment derived from GnRH. GAP can increase the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in rat anterior pituitary cells. GAP also inhibit the secretion of prolactin .

HY-RS11654

RAP1GAP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAP1GAP Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1GAP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1GAP Human Pre-designed siRNA Set A RAP1GAP Human Pre-designed siRNA Set A

HY-RS11559

RAB3GAP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAB3GAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for RAB3GAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAB3GAP1 Human Pre-designed siRNA Set A RAB3GAP1 Human Pre-designed siRNA Set A

HY-RS11560

RAB3GAP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAB3GAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for RAB3GAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAB3GAP2 Human Pre-designed siRNA Set A RAB3GAP2 Human Pre-designed siRNA Set A

HY-RS11655

RAP1GAP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAP1GAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1GAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1GAP2 Human Pre-designed siRNA Set A RAP1GAP2 Human Pre-designed siRNA Set A

HY-114865

BMS-192364	RGS Protein Calcium Channel	Neurological Disease
BMS-192364 is targeting the G_α-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux .

HY-106225

Rotigaptide ZP123	Gap Junction Protein	Cardiovascular Disease
Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically atrial fibrillation .

HY-117275

Meclofenamic acid 4 Publications Verification Meclofenamate	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite	Neurological Disease Metabolic Disease Inflammation/Immunology
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective *gap-junction* blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-117275A

Meclofenamic acid sodium hydrate Meclofenamate sodium hydrate	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite	Neurological Disease Metabolic Disease Inflammation/Immunology
Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective *gap-junction* blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-14584A

PQ-1 succinate	Gap Junction Protein Apoptosis Caspase	Others
PQ-1 succinate is an inhibitor for gap junction, which suppresses the gap junction dye transfer activity in retinal neurosensory R28 cells, and inhibits the CoCl₂-induced ischemic apoptosis in retinal cell .

HY-15204

Tonabersat Maximum Cited Publications 15 Publications Verification SB-220453	Gap Junction Protein	Neurological Disease Inflammation/Immunology
Tonabersat (SB-220453) is a *gap-junction* modulator. Tonabersat prevents inflammatory damage in the central nervous system .

HY-153125

DLRIE	Biochemical Assay Reagents	Others
DLRIE can be used for the synthesis of cationic lipid GAP-DLRIE which can be used to enhance the delivery and expression of plasmid DNA .

HY-112766

DPyPE	Liposome	Others
DPyPE is a phosphatidylethanolamine lipid composed of polyisoprene alkyl chains. DPyPE is a co-lipid forvaxfectin mixed with GAP-DMORIE in a 1:1 ratio .

HY-D1777

Pyrromethene 605 PM605	Fluorescent Dye	Others
Pyrromethene 605 (PM605) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-W248118

Pyrromethene 556 PM556	Fluorescent Dye	Others
Pyrromethene 556 (PM556) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-W248583

Pyrromethene 650 PM650	Fluorescent Dye	Others
Pyrromethene 650 (PM650) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-124381

ML10375	Others	Others
ML10375 is a compound that modulates 5-HT4 and 5-HT2 receptors, affects gap junction coupling in rat atrial myocytes, and regulates intracellular cAMP concentration and L-type calcium current.

HY-B1320

Meclofenamic acid sodium 4 Publications Verification Meclofenamate sodium	Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)	Inflammation/Immunology Cancer
Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective *gap-junction* blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .

HY-B2227

Lactate 5+ Cited Publications Lactic acid	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .

HY-117275S1

Meclofenamic acid-13C6 Meclofenamate-¹³C₆	Isotope-Labeled Compounds Gap Junction Protein Endogenous Metabolite	Inflammation/Immunology
Meclofenamic acid- ¹³C₆ is the ¹³C₆ labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.

HY-B1320R

Meclofenamic acid sodium (Standard)	Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)	Inflammation/Immunology Cancer
Meclofenamic acid (sodium) (Standard) is the analytical standard of Meclofenamic acid (sodium). This product is intended for research and analytical applications. Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .

HY-117275S

Meclofenamic acid-d4 Meclofenamate-d₄	Isotope-Labeled Compounds Gap Junction Protein Endogenous Metabolite	Inflammation/Immunology
Meclofenamic acid-d₄ is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker[1][2][3].

HY-D2194

AgAuSe-COOH (1000 nm)	Fluorescent Dye	Others
AgAuSe-COOH (1000 nm) is a fluorescent quantum dot that emits fluorescence in the near-infrared II region, with an emission peak reaching 1000 nm. AgAuSe-COOH (1000 nm) has the advantages of narrow band gap, large Stokes shift, and good photostability. AgAuSe-COOH (1000 nm) can bind proteins, antibodies, peptides, PEG, etc., and can be widely used in the field of biological imaging.

HY-B2227R

Lactate (Standard)	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
Lactate (Standard) is the analytical standard of Lactate. This product is intended for research and analytical applications. Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .

HY-B1367

Carbenoxolone disodium 3 Publications Verification	Gap Junction Protein Orthopoxvirus 11β-HSD	Infection Inflammation/Immunology
Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD . Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication . Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation. Carbenoxolone disodium inhibits Vaccinia virus replication.

HY-106644

Femoxetine FG4963 free acid	5-HT Receptor	Neurological Disease
Femoxetine is a serotonin (5-HT) inhibitor with antidepressant properties. Femoxetine increases serotonin levels in the brain by preventing serotonin from being reabsorbed by nerve cells, resulting in increased concentrations of the neurotransmitter in the synaptic gap, which enhances serotonin signaling. Femoxetine can be used to study the role of serotonin in depression and other emotional disorders, and how 5-HT reuptake inhibitors affect mood and behavior .

HY-106644A

Femoxetine hydrochloride FG4963	5-HT Receptor	Neurological Disease
Femoxetine hydrochloride is a serotonin (5-HT) inhibitor with antidepressant properties. Femoxetine hydrochloride increases serotonin levels in the brain by preventing serotonin from being reabsorbed by nerve cells, resulting in increased concentrations of the neurotransmitter in the synaptic gap, which enhances serotonin signaling. Femoxetine hydrochloride can be used to study the role of serotonin in depression and other emotional disorders, and how 5-HT reuptake inhibitors affect mood and behavior .

HY-128692

Lucifer Yellow CH dilithium salt 1 Publications Verification	Fluorescent Dye	Neurological Disease
Lucifer Yellow CH dilithium salt is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .

HY-W127715

Lucifer Yellow CH dipotassium salt 1 Publications Verification	Fluorescent Dye	Others
Lucifer Yellow CH dipotassium is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .

HY-134110

N-Methylarachidonamide	Endogenous Metabolite	Metabolic Disease
Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid (CB1) receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.

HY-134055

Arachidonoyl-N,N-dimethyl amide Arachidonic acid-N,N-dimethyl amide	Cannabinoid Receptor	Metabolic Disease
Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N,N-dimethyl amide is an analog of anandamide that exhibits weak or no binding to the human central cannabinoid (CB1) receptor (Ki >1 μM). It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.

HY-A0170

Trovafloxacin 2 Publications Verification	Bacterial Topoisomerase Antibiotic	Infection
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC₅₀ of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .

HY-103399

Trovafloxacin mesylate 2 Publications Verification	Bacterial Topoisomerase Antibiotic	Infection
Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC₅₀ of 4 μM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .

HY-126247

BI-2852	Ras	Cancer
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

HY-A0170R

Trovafloxacin (Standard)	Bacterial Topoisomerase Antibiotic	Infection
Trovafloxacin (Standard) is the analytical standard of Trovafloxacin. This product is intended for research and analytical applications. Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC₅₀ of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .

HY-15350

Trovirdine hydrochloride LY 300046 hydrochloride	Reverse Transcriptase	Others
Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells .

HY-126247B

(R)-BI-2852	Others	Cancer
(R)-BI-2852 is the isomer of BI-2852 (HY-126247), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

HY-161783

HDAC6-IN-45	HDAC Keap1-Nrf2 Reactive Oxygen Species Apoptosis	Neurological Disease
HDAC6-IN-45 (Compound 15) is a selective inhibitor for HDAC6 with IC₅₀ of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H₂O₂-induced ROS production, inhibits apoptosis in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimer's Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier (BBB) permeability .

Cat. No.	Product Name	Type

HY-128692

Lucifer Yellow CH dilithium salt

1 Publications Verification

Fluorescent Dyes/Probes

Lucifer Yellow CH dilithium salt is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .

HY-W127715

Lucifer Yellow CH dipotassium salt

1 Publications Verification

Fluorescent Dyes/Probes

Lucifer Yellow CH dipotassium is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .

HY-D1777

Pyrromethene 605 PM605	Fluorescent Dyes/Probes
Pyrromethene 605 (PM605) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-W248118

Pyrromethene 556 PM556	Fluorescent Dyes/Probes
Pyrromethene 556 (PM556) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-W248583

Pyrromethene 650 PM650	Dyes
Pyrromethene 650 (PM650) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-D2194

AgAuSe-COOH (1000 nm)	Fluorescent Dyes/Probes
AgAuSe-COOH (1000 nm) is a fluorescent quantum dot that emits fluorescence in the near-infrared II region, with an emission peak reaching 1000 nm. AgAuSe-COOH (1000 nm) has the advantages of narrow band gap, large Stokes shift, and good photostability. AgAuSe-COOH (1000 nm) can bind proteins, antibodies, peptides, PEG, etc., and can be widely used in the field of biological imaging.

Cat. No.	Product Name	Target	Research Area

HY-P0139

Gap 27 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment .

HY-P1082

Gap 26 Maximum Cited Publications 7 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-P1082A

Gap 26 TFA Maximum Cited Publications 7 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-P1136A

Gap19 TFA 4 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .

HY-P1136B

*TAT-Gap19*	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-P1136C

*TAT-Gap19 TFA*	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19 TFA, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 TFA does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 TFA traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-P3606

GnRH Associated Peptide (1-24), human gap (1-24), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-P3605

GnRH Associated Peptide (25-53), human gap (25-53), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-P1136

Gap19	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .

HY-P5389

Connexin mimetic peptide 40GAP27	Peptides	Others
Connexin mimetic peptide 40GAP27 is a biological active peptide. (This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.)

HY-P5387

Connexin mimetic peptide 40,37GAP26	Peptides	Others
Connexin mimetic peptide 40,37GAP26 is a biological active peptide. (This peptide corresponds to the GAP26 domain of the extracellular loop of the major vascular connexins (Cx37, Cx40), designated as 37, 40Gap 26 according to Cx homology. It was used to investigate the role of gap junctions in the spread of endothelial hyperpolarizations evoked by cyclopiazonic acid (CPA) through the wall of the rodent iliac artery. The gap junction plaques constructed from Cx37 and Cx40 were abundant in the endothelium. This peptide provides inhibitory effects against subintimal hyperpolarization.)

HY-P1174

*GnRH Associated Peptide (GAP) (1-13), human*	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-13), human is an amino acid peptide fragment derived from GnRH. GAP can increase the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in rat anterior pituitary cells. GAP also inhibit the secretion of prolactin .

HY-P1137

10Panx	Peptides	Others
10Panx is a biological active peptide. (This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1b (IL-1b) in response to P2X7R activation.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-117275

Meclofenamic acid 4 Publications Verification Meclofenamate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective *gap-junction* blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-B1320

Meclofenamic acid sodium 4 Publications Verification Meclofenamate sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)
Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective *gap-junction* blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .

HY-B2227

Lactate Maximum Cited Publications 7 Publications Verification Lactic acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .

HY-117275A

Meclofenamic acid sodium hydrate Meclofenamate sodium hydrate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective *gap-junction* blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-B1320R

Meclofenamic acid sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)
Meclofenamic acid (sodium) (Standard) is the analytical standard of Meclofenamic acid (sodium). This product is intended for research and analytical applications. Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .

HY-B2227R

Lactate (Standard)	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Lactate (Standard) is the analytical standard of Lactate. This product is intended for research and analytical applications. Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .

Species:	Human (5)
Tag:	His (5)
Source:	HEK293 (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P75175

	GAP43 Protein, Human (HEK293, His) Neuromodulin; pp46; gap43; B-50	Human	HEK293
	The GAP43 protein plays a central role in nerve growth and is found primarily in the active "growth cones" at the tips of axons. It induces axonal and dendritic filopodia, which are critical for neurodevelopmental dynamics. GAP43 Protein, Human (HEK293, His) is the recombinant human-derived GAP43 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72205

	GJA1 Protein, Human (His) Connexin 43; Connexin-43; Cx 43; Cx43; CXA1_HUMAN; DFNB38; gap junction 43 kDa heart protein; gap junction alpha-1 protein; gap junction protein alpha 1 43kDa connexin 43; ; gap junction protein alpha 1 43kDa; gap junction protein alpha like; GJA 1; Gja1; GJAL; ODD; ODDD; ODOD; SDTY3	Human	E. coli
	The GJA1 protein regulates bladder capacity through gap junctions, clusters of transmembrane channels that allow the diffusion of low molecular weight materials between adjacent cells. GJA1 protein also regulates NOV expression and localization and is important for ventricular gap junction communication. GJA1 Protein, Human (His) is the recombinant human-derived GJA1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GJA1 Protein, Human (His) is 150 a.a., with molecular weight of ~22 kDa.

HY-P70997

	SUMO1 Protein, Human (His) Small Ubiquitin-Related Modifier 1; SUMO-1; gap-Modifying Protein 1; GMP1; SMT3 Homolog 3; Sentrin; Ubiquitin-Homology Domain Protein PIC1; Ubiquitin-Like Protein SMT3C; Smt3C; Ubiquitin-Like Protein UBL1; SUMO1; SMT3C; SMT3H3; UBL1	Human	E. coli
	SUMO1 Protein is a member of the SUMO (small ubiquitin-like modifier) protein family. SUMO1 binds to target proteins as part of a post-translational modification system. It is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO1 also regulates the function of several proteins via non-covalent interactions. SUMO1 Protein, Human (His) is the recombinant human-derived SUMO1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SUMO1 Protein, Human (His) is 101 a.a., with molecular weight of 17-19 kDa.

HY-P71619

	SYNGAP1 Protein, Human (His) DKFZp761G1421 ; KIAA1938; MRD5; Neuronal Rasgap; OTTHUMP00000064825; p135 Syngap; Ras GTPase activating protein Syngap; Synaptic Ras-gap 1; SYNgap 1; SYNgap1	Human	E. coli
	SYNGAP1 protein is a major postsynaptic density component that plays a critical regulatory role in the Ras-cAMP pathway, affecting synaptic function and plasticity. At excitatory synapses, it is part of the NMDAR signaling complex and may influence NMDAR-dependent control of AMPAR potentiation, trafficking, and synaptic plasticity. SYNGAP1 Protein, Human (His) is the recombinant human-derived SYNGAP1 protein, expressed by E. coli , with N-His labeled tag. The total length of SYNGAP1 Protein, Human (His) is 183 a.a., with molecular weight of ~25.5 kDa.

HY-P702856

	G3BP1 Protein, Human (His) G3BP-1; ATP-dependent DNA helicase VIII; hDH VIII; gap SH3 domain-binding protein 1	Human	E. coli
	G3BP1 Protein, Human (His) is the recombinant human-derived G3BP1, expressed by E. coli , with N-6*His labeled tag. The total length of G3BP1 Protein, Human (His) is 466 a.a.,

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-117275S1

Meclofenamic acid-13C6
Meclofenamic acid- ¹³C₆ is the ¹³C₆ labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.

HY-117275S

Meclofenamic acid-d4
Meclofenamic acid-d₄ is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker[1][2][3].

HY-B1588S

Carbenoxolone-d4

Carbenoxolone-d₄ is deuterium labeled Carbenoxolone. Carbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties[3]. Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the research of chronic liver disease[2]. Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD[1]. Carbenoxolone is small molecule Pannexin1 (Panx1,is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop[4].Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that converts inactive glucocorticoid into an active form. Carbenoxolone has antiviral activity against DENV infection targeting the virus itself[6].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83146

	GAP43 Antibody (YA2891) gap43; Neuromodulin; Axonal membrane protein gap-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	GAP43 Antibody (YA2891) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2891), targeting GAP43, with a predicted molecular weight of 25 kDa (observed band size: 46 kDa). GAP43 Antibody (YA2891) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P80628

	Connexin 43 Antibody Connexin 43; Connexin-43; Cx 43; Cx43; CXA1_HUMAN; DFNB38; gap junction 43 kDa heart protein; gap junction alpha-1 protein; gap junction protein alpha 1 43kDa (connexin 43); gap junction protein alpha 1 43kDa; gap junction protein alpha like; GJA 1; Gja1	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Connexin 43 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 43 kDa, targeting to Connexin 43. It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P82687

	G3BP Antibody (YA2432) G3BP1; G3BP; Ras GTPase-activating protein-binding protein 1; G3BP-1; ATP-dependent DNA helicase VIII; hDH VIII; gap SH3 domain-binding protein 1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	G3BP Antibody (YA2432) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2432), targeting G3BP, with a predicted molecular weight of 52 kDa (observed band size: 68 kDa). G3BP Antibody (YA2432) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

HY-P80905

	SUMO1 Antibody (YA047) SUMO1; SMT3C; SMT3H3; UBL1; OK/SW-cl.43; Small ubiquitin-related modifier 1; SUMO-1; gap-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein	WB, IHC-P	Human, Mouse, Rat
	SUMO1 Antibody (YA047) is a non-conjugated and Rabbit origined monoclonal antibody, targeting to SUMO1. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P83136

	RACGAP1 Antibody (YA2881) CYK4; gap; gap1; ID gap; MgcRacgap; Racgap1	WB, IHC-P, ICC/IF	Human
	RACGAP1 Antibody (YA2881) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2881), targeting RACGAP1, with a predicted molecular weight of 71 kDa (observed band size: 71 kDa). RACGAP1 Antibody (YA2881) can be used for WB, IHC-P, ICC/IF experiment in human background.

HY-P82081

	RAP1GAP Antibody (YA1826) RAP1gap; KIAA0474; RAP1GA1; Rap1 GTPase-activating protein 1; Rap1gap; Rap1gap1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	RAP1GAP Antibody (YA1826) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1826), targeting RAP1GAP, with a predicted molecular weight of 73 kDa (observed band size: 95 kDa). RAP1GAP Antibody (YA1826) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P82000

	GIT1 Antibody (YA1745) ARF gap GIT1; CAT 1; CaT1; GIT1	WB, FC	Human, Mouse, Rat
	GIT1 Antibody (YA1745) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1745), targeting GIT1, with a predicted molecular weight of 84 kDa (observed band size: 84 kDa). GIT1 Antibody (YA1745) can be used for WB, FC experiment in human, mouse, rat background.

HY-P83466

	RGS6 Antibody (YA3211) regulator of G protein signaling 6; gap; S914; HA117	WB	Human
	RGS6 Antibody (YA3211) is a biotin-conjugated non-conjugated IgG antibody, targeting RGS6, with a predicted molecular weight of 54 kDa (observed band size: 54 kDa). RGS6 Antibody (YA3211) can be used for WB experiment in human background.