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Results for "

hURAT1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W011711
    Benzarone

    Fragivix

    		 URAT1 Oxidative Phosphorylation Apoptosis Metabolic Disease
    Benzarone (Fragivix) is an oral inhibitor of human urate transporter 1 (hURAT1) with an IC50 value of 2.8 μM, and it also acts as an uncoupler of oxidative phosphorylation. Benzarone can cause liver damage and promote cell apoptosis and necrosis. Benzarone can be used to lower serum uric acid levels and for research in vascular diseases [1] .
    Benzarone
  • HY-153969
    URAT1 inhibitor 6

    		URAT1 Inflammation/Immunology
    URAT1 inhibitor 6 (Compound 1h) is a potent URAT1 inhibitor (IC50: 35 nM for hURAT1). URAT1 inhibitor 6 is 200- and 8-fold more potent than parent Lesinurad (HY-15258) and Benzbromarone (HY-B1135). URAT1 inhibitor 6 can be used for research of inflammation [1].
    URAT1 inhibitor 6
  • HY-162829
    hURAT1 inhibitor 1

    		URAT1 GLUT Metabolic Disease
    hURAT1 inhibitor 1 (compound 27b) is an isomarine-based, orally active dual hURAT1/GLUT9 inhibitor with IC50s of 0.16 μM and 4.47 μM, respectively, and has anti-hyperuricemia effects. hURAT1 inhibitor 1 showed significant uric acid-lowering activity in a hyperuricemia mouse model (10 mg/kg dose). hURAT1 inhibitor 1 had no significant in vitro cytotoxicity or in vivo hepatotoxicity and showed good PK characteristics [1].
    hURAT1 inhibitor 1
  • HY-W011711R
    Benzarone (Standard)

    		URAT1 Metabolic Disease
    Benzarone (Standard) is the analytical standard of Benzarone. This product is intended for research and analytical applications. Benzarone (Fragivix) is a potent human uric acid transporter 1 (hURAT1) inhibitor, with an IC50 of 2.8 μM in oocyte. Benzarone could lower uric acid serum levels [1].
    Benzarone (Standard)
  • HY-156624
    Lingdolinurad

    		URAT1 Metabolic Disease
    Lingdolinurad is urate transporter inhibitor, targeting to hURAT1.Lingdolinurad can be used for research in hyperuricemia in vitro and in vivo [1].
    Lingdolinurad

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