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peptide deformylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (1) Antibiotic (3) Apoptosis (1) Bacterial (3) Biochemical Assay Reagents (1) Influenza Virus (1) MMP (2) TNF Receptor (1)
By Research Areas:	Cancer (4) Infection (5)

8

Inhibitors & Agonists

1

Peptides

2

Natural
Products

2

Recombinant Proteins

Targets Recommended: Formyl Peptide Receptor (FPR) CGRP Receptor Amyloid-β

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Actinonin 5 Publications Verification (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

FR-202306	Others	Others
FR-202306 is a compound with antibacterial and peptide deformylase inhibitory activities, isolated from microorganisms, which has an inhibitory effect on the peptide deformylase of Staphylococcus aureus and also has antibacterial activity.

For-Met-Leu-pNA	Biochemical Assay Reagents	Cancer
For-Met-Leu-pNA is an N-formylated peptide substrate that can be used in the deformylase assays .

M7594_0037	Others	Cancer
M7594_0037 is a potent inhibitor of human peptide deformylase (HsPDF) that has anti-tumor activity .

PDF-IN-1	Antibiotic	Infection
PDF-IN-1 (compound 2) is a potential Peptide deformylase (PDF) inhibitor. PDF-IN-1 can be used for the development of new broad-spectrum antibiotics 。

FR198248	Influenza Virus	Infection
FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor. FR198248 can be isolated from Aspergillus flavipes. FR198248 potently inhibits the PDF of Staphylococcus aureus with an IC₅₀ of 3.6 µM. FR198248 can be used for antiviral and antibacterial research .

LBM-415 NVP-PDF 713; VIC-104959	Bacterial Antibiotic	Infection
LBM-415 (NVP-PDF 713) is a peptide deformylase (PDF) inhibitor that exhibits inhibitory activity against various antimicrobial-resistant gram-positive cocci, with a MIC₉₀ range of 0.12-8 µg/ml. Additionally, inhibiting efflux pump activity can enhance bacterial sensitivity to LBM415, thereby improving its antibacterial efficacy .

Cat. No.	Product Name	Target	Research Area

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

Cat. No.	Product Name	Category	Target	Chemical Structure

Actinonin 5 Publications Verification (-)-Actinonin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

FR198248	Structural Classification Microorganisms Source classification Phenols Polyphenols	Influenza Virus
FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor. FR198248 can be isolated from Aspergillus flavipes. FR198248 potently inhibits the PDF of Staphylococcus aureus with an IC₅₀ of 3.6 µM. FR198248 can be used for antiviral and antibacterial research .

Species:	Staphylococcus aureus (2)
Tag:	His (2) SUMO (1)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	Peptide deformylase Protein, S. aureus (P.pastoris, His) def; def1; pdf1peptide deformylase; PDF; Polypeptide deformylase	Staphylococcus aureus	P. pastoris
	Peptide deformylase, a crucial enzyme in protein biosynthesis, catalyzes the removal of the formyl group from the N-terminal methionine of newly synthesized proteins. Displaying broad specificity at positions beyond the N-terminal L-methionine, the enzyme ensures proper maturation and functionality of proteins, emphasizing its essential contribution to the intricate process of protein synthesis and modification. Peptide deformylase Protein, S. aureus (P.pastoris, His) is the recombinant Staphylococcus aureus-derived Peptide deformylase protein, expressed by P. pastoris , with N-6*His labeled tag.

	Peptide deformylase Protein, S. aureus (His, SUMO) def; def1; pdf1peptide deformylase; PDF; EC 3.5.1.88; Polypeptide deformylase	Staphylococcus aureus	E. coli

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