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Results for "

xc(-) inhibitor

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139087
    Erastin2

    		Ferroptosis Metabolic Disease
    Erastin2, an Erastin (HY-15763) analog, is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter
    Erastin2
  • HY-114481
    Imidazole ketone erastin
    25+ Cited Publications

    IKE

    		 Ferroptosis Cancer
    Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system xc - and an activator of ferroptosis. Imidazole ketone erastin has anti-tumor activity .
    Imidazole ketone erastin
  • HY-B0774
    Seratrodast
    4 Publications Verification

    AA 2414

    		 Ferroptosis JNK MDM-2/p53 Prostaglandin Receptor Reactive Oxygen Species Neurological Disease Inflammation/Immunology Endocrinology Cancer
    Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity .
    Seratrodast
  • HY-162785
    XC219

    		CDK Infection
    XC219 (compound 43) is a cyclin-dependent kinase CDK) inhibitor, that covalently binds to CDK active site Lys. XC219 can be used in antifungal research .
    XC219
  • HY-14986
    JAK-IN-32

    		JAK Others
    JAK-IN-32 (XC) is a bi-aryl meta-pyrimidine inhibitor of JAK kinase .
    JAK-IN-32
  • HY-122006
    NPD926

    		Reactive Oxygen Species Cancer
    NPD926 is a small molecule that targets glutathione and induces cancer cell death. The Xc - system and glutathione are therapeutic targets in cancer. NPD926 causes cellular glutathione depletion and subsequent generation of reactive oxygen species (ROS), thereby sensitizing fibroblasts to Xc - system inhibitors. NPD926 is a ROS inducer with anticancer activity. .
    NPD926
  • HY-111137
    Puquitinib

    XC-302 free base

    		 Others Cancer
    Puquitinib (XC-302 free base) is a multi-target inhibitor with the activity of inducing autophagy in nasopharyngeal carcinoma cells by inhibiting the PI3K/AKT/mTOR signaling pathway. Puquitinib was able to inhibit the proliferation of CNE-2 cells, showing a dose-dependent antiproliferative effect. Puquitinib induced the formation of autophagosomes and autolysosomes in CNE-2 cells, which were observed by fluorescence microscopy and electron microscopy. Puquitinib promoted the formation of LC3-II and increased the expression of beclin 1, while reducing the level of p62. Puquitinib inhibited the PI3K/AKT/mTOR pathway by reducing the expression of p-AKT and p-mTOR. Puquitinib also induced apoptosis in CNE-2 cells, and when autophagy was inhibited, the apoptosis rate was reduced, which means that autophagy may interact with apoptosis to induce cell death .
    Puquitinib
  • HY-B0774R
    Seratrodast (Standard)

    		Ferroptosis JNK MDM-2/p53 Prostaglandin Receptor Reactive Oxygen Species Neurological Disease Inflammation/Immunology Endocrinology Cancer
    Seratrodast (Standard) is the analytical standard of Seratrodast. This product is intended for research and analytical applications. Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity .
    Seratrodast (Standard)

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