α-Conotoxin MrIC 

α-Conotoxin MrIC is an α7nAChR biased agonist. α-Conotoxin MrIC exclusively activates α7nAChR regulated by type II positive allosteric modulators, including PNU120596. α-Conotoxin MrIC can be used to study neurological diseases and also to probe the pharmacological properties of α7nAChR^[1].

α7nAChR^[1].

1835.07

C₇₄H₁₁₁N₂₃O₂₄S₄

1417816-41-1

Pro-Glu-Cys-Cys-Thr-His-Pro-Ala-Cys-His-Val-Ser-Asn-Pro-Glu-Leu-Cys-NH2 (Disulfide bridge:Cys3-Cys9, Cys4-Cys17)

PECCTHPACHVSNPELC-NH2 (Disulfide bridge:Cys3-Cys9, Cys4-Cys17)

O=C1N2[C@@](CCC2)(C(=O)N[C@@H](C)C(=O)N[C@@]3(C(=O)N[C@@H](CC4=CN=CN4)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N5[C@](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(N)=O)CSSC[C@@](C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@H]1CC6=CN=CN6)[H])(NC(=O)[C@@H](NC([C@@H](NC(=O)[C@@H]7CCCN7)CCC(O)=O)=O)CSSC3)[H])(CCC5)[H])[H])[H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mueller A, et al. α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochem Pharmacol. 2015 Mar 15;94(2):155-63.  [Content Brief]