AMPK

AMP-activated protein kinase

AMPK

AMPK Isoform Specific Products:

AMPK Isoform Comparison

AMPK Related Products (238)
Recombinant Proteins (4)
Antibodies (17)
AMPK Isoform Comparison

By Effects:	Inhibitors (48) Substrate (1) Agonists (3) Activators (154) Modulator (1) Inducers (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-15142

Doxorubicin hydrochloride	Inhibitor	99.90%
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.

HY-13418A

Dorsomorphin	Inhibitor	99.91%
Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (K_i=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).

HY-B0627

Metformin	Activator	99.98%
Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.

HY-13417

AICAR	Activator	99.98%
AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor.

HY-13418

Dorsomorphin dihydrochloride	Inhibitor	99.91%
Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a K_i of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).

HY-P10769

MOTS-c (mouse)	Activator	99.23%
MOTS-c (mouse) is a mitochondrial-derived polypeptide that can be used to regulates pancreatic cell function. MOTS-c (mouse) reduces insulin secretion and expression in INS-1E cells, and enhances glucagon secretion and expression in αTC-1 cells. MOTS-c (mouse) decreases the apoptosis in INS-1E and αTC-1. MOTS-c (mouse) counteracts diet-induced obesity and insulin resistance through AMPK activation.

HY-172157

HDAC11-IN-2	Agonist
HDAC11-IN-2 (compound B6) is a high selective Histone Deacetylase 11 (HDAC11) inhibitor. HDAC11-IN-2 inhibits HDAC11 and HDAC8 with IC₅₀s of 51.1 ×10^-3 μM and 5 μM, respectively. HDAC11-IN-2 inhibits denovolipogenesis (DNL) and promotes fatty acid oxidation, thus mitigating hepaticlipid accumulation and pathological symptoms in MASLD mice. HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at Thr172 through the inhibition of HDAC11, consequently modulating DNL and fatty acid oxidation in the liver.

HY-119327

Butylate
Butylate is a compound involved in platelet research. Platelet activation can cause autophagy, which is partly mediated by the AMPK-MTOR pathway and is related to sphingolipid metabolism. Butylate mentioned in the study may be a tool or control substance for studying related metabolic processes.

HY-17471A

Metformin hydrochloride	Activator	99.98%
Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.

HY-50662

A-769662	Activator	99.33%
A-769662 is a potent, reversible AMPK activator with EC₅₀ of 0.8 μM.

HY-111363

MK8722	Activator	99.55%
MK8722 is a potent and systemic pan-AMPK activator.

HY-156498

RMC-7977	Inhibitor	99.48%
RMC-7977 is an orally active triple-complex RAS inhibitor that can simultaneously bind to cyclophilin A (CYPA) (K_d = 195 nM) and KRAS (G12V) (K_d = 292 μM). It exhibits broad-spectrum inhibitory activity against KRAS, NRAS, and HRAS proteins and their various wild-type and mutant variants. RMC-7977 induces apoptosis by inhibiting the phosphorylation of ERK, CRAF, and RSK, as well as increasing PARP cleavage. This leads to tumor regression, reduces resistance in KRAS^G12C cancer models, and demonstrates good tolerability across various RAS cancer models.

HY-12357

Bempedoic acid	Activator	99.97%
Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK.

HY-112083

BAY-3827	Inhibitor	99.66%
BAY-3827 is a potent and selective AMPK inhibitor with IC₅₀ values of 1.4 nM at low (10 μM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines.

HY-148189

Aldometanib		99.37%
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis.

HY-10249

GSK-690693	Inhibitor	99.03%
GSK-690693 is an ATP-competitive pan-Akt inhibitor with IC₅₀s of 2 nM, 13 nM, 9 nM for Akt1, Akt2 and Akt3, respectively. GSK-690693 is also an AMPK inhibitor, affects Unc-51-like autophagy activating kinase 1 (ULK1) activity and robustly inhibits STING-dependent IRF3 activation.

HY-13417A

AICAR phosphate	Activator	99.98%
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor.

HY-14615

[6]-Gingerol	Activator	99.45%
[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

HY-16397A

Phenformin hydrochloride	Activator	99.64%
Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity.

HY-19805

STO-609	Inhibitor	98.13%
STO-609 is a selective and cell-permeable inhibitor of the Ca²⁺/calmodulin-dependent protein kinase kinase (CaM-KK), with K_i values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC₅₀ ~0.02 g/ml.

Dorsomorphin			AMPK, Ki: 109 nM					99.91%
Metformin			AMPK					99.98%
AICAR			AMPK					99.98%
Dorsomorphin dihydrochloride			AMPK, Ki: 109 nM					99.91%
HDAC11-IN-2				AMPK α1β1γ1
Metformin hydrochloride			AMPK					99.98%
A-769662			AMPK, EC₅₀: 0.8 μM					99.33%
MK8722			AMPK					99.55%
Bempedoic acid			AMPK					99.97%
AICAR phosphate			AMPK					99.98%
[6]-Gingerol			AMPK					99.45%
Phenformin hydrochloride			AMPK					99.64%
EX229				AMPK α1β1γ1, Kd: 0.06 μM	AMPK α2β1γ1, Kd: 0.06 μM	AMPK α1β2γ1, Kd: 0.51 μM		98.92%
WZ4003	NUAK1, IC₅₀: 20 nM	NUAK2, IC₅₀: 100 nM						98.03%
HTH-01-015	NUAK1, IC₅₀: 100 nM							98.81%
PF-06409577				AMPK α1β1γ1, EC₅₀: 7 nM				99.83%
Palmitelaidic Acid			AMPK					≥99.0%
Danthron			AMPK					99.19%
MOTS-c(human) acetate			AMPK					98.97%
MRT199665	NUAK1, IC₅₀: 3 nM	NUAK2, IC₅₀: 120 nM						99.74%
PF-739				AMPK α1β1γ1, EC₅₀: 8.99 nM	AMPK α2β1γ1, EC₅₀: 5.23 nM	AMPK α1β2γ1, EC₅₀: 126 nM	AMPK α2β2γ1, EC₅₀: 42.2 nM	98.05%
Narazaciclib	ARK5, IC₅₀: 5 nM							99.12%
ASP4132			AMPK, EC₅₀: 18 nM					99.32%
Metformin-d₆ hydrochloride			AMPK					98.79%
Ginkgolide C			AMPK					≥98.0%
RSVA405			AMPK, EC₅₀: 1 μM (in cell-based assays)					99.72%
8-Chloroadenosine			AMPK					99.97%
ZLN024 hydrochloride				AMPK α1β1γ1, EC₅₀: 0.42 μM	AMPK α2β1γ1, EC₅₀: 0.95 μM		AMPK α2β2γ1, EC₅₀: 0.13 μM	98.47%
MK-3903			AMPK, EC₅₀: 8 nM					98.03%
MT 63-78			AMPK, EC₅₀: 25 μM					98.50%
SAMS			AMPK					99.88%
PF-06685249				AMPK α1β1γ1, EC₅₀: 12 nM				98.32%
Ampkinone			AMPK					99.28%
YLF-466D			AMPK					98.58%
Gomisin J			AMPK					99.87%
AMPK activator 2 hydrochloride			AMPK					99.65%
AMPK activator 1			AMPK, EC₅₀: 0.1 μM					98.53%
AMPK-IN-1							AMPK α2β2γ1, EC₅₀: 551 nM
3α-Hydroxymogrol			AMPK					99.88%
IQZ23			AMPK
LRRK2-IN-8	NUAK1, IC₅₀: 10-100 nM
Kazinol B			AMPK
AMPK activator 9					AMPK α2β1γ1, EC₅₀: 1.1 μM
AMPK activator 8				AMPK α1β1γ1, EC₅₀: 11 nM	AMPK α2β1γ1, EC₅₀: 27 nM	AMPK α1β2γ1, EC₅₀: 4 nM	AMPK α2β2γ1, EC₅₀: 2 nM
AMPK activator 10			AMPK
Etilefrine			AMPK
Tanshinol borneol ester			AMPK
AMPK activator 2			AMPK
LRRK2/NUAK1/TYK2-IN-1	NUAK1
PF-06679142				AMPK α1β1γ1, EC₅₀: 22 nM
AMPK-IN-6			AMPK, IC₅₀: 0.093 μM
ZLN024				AMPK α1β1γ1, EC₅₀: 0.42 μM	AMPK α2β1γ1, EC₅₀: 0.95 μM		AMPK α2β2γ1, EC₅₀: 0.13 μM

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AMPK

AMPK

AMPK Isoform Specific Products:

AMPK Isoform Specific Products:

AMPK Related Products (238)

Recombinant Proteins (4)

Antibodies (17)

AMPK Isoform Comparison

AMPK Related Products (238):