2. Recombinant Proteins
  3. Receptor Proteins
  4. Nuclear Receptor Superfamily

Nuclear Receptor Superfamily

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Nuclear Receptor Superfamily

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Nuclear receptors (NRs) are important transcription factors capable of exerting regulation of gene expression in the nucleus in response to various extracellular and intracellular signals. NRs are activated by binding of small hydrophobic compounds, such as steroids, retinoids, and thyroid hormones. The interaction of ligand and receptor triggers a conformational change in the receptor proteins, which enables an interaction with cofactors and specific cis-regulatory DNA sequences called hormone response elements (HREs) to subsequently modify gene expression. NRs are involved in widely diverse physiological functions such as control of development, reproduction, metabolism, cell differentiation, and homeostasis. NRs share a similar modular domain structure, which includes, from N-terminus to C-terminus: 1) domains A and B make up the highly variable (both in length and sequence) amino/N-terminal domain (NTD); 2) the DNA-binding domain (DBD), which consists of two zinc finger DNA-binding motifs; 3) the hinge D-region, often contains the main nuclear localization sequence (NLS); 4) the ligand-binding domain (LBD); 5) some receptors also contain a short, variable carboxy/C-terminal domain (CTD; F domain). Most NRs are regulated endogenously by small lipophilic ligands, but this protein family also contains “orphan” members for which lack identified ligand molecules. NRs are divided into seven subfamilies, Subgroup 0 to Subgroup 6, based on sequence alignment and phylogenetic tree construction. Among them, the Subgroup 1 is large family which is formed by thyroid hormone receptors (TR), retinoic acid receptors (RAR), peroxisome proliferator activated receptors (PPAR), reverse-Erb receptors (REV-ERB, retinoic acid related receptors (ROR), farnesoid X receptors (FXR), liver X receptors (LXR), and vitamin D receptors (VDR).

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Cat. No. Product Name / Synonyms Species Source
  • HY-P790012
    PPAR-gamma Protein, Human (P37231-2, His)

    CIMT1; GLM1; NR1C31; PPARG2; PPARG5; PPARgamma; PPARG

    		Human E. coli
    The PPAR gamma protein is a nuclear receptor that binds to peroxisome proliferators and is activated upon ligand binding to specific PPREs on DNA. It regulates target gene transcription and controls fatty acid metabolism. PPAR-gamma Protein, Human (P37231-2, His) is the recombinant human-derived PPAR-gamma protein, expressed by E. coli , with C-6*His labeled tag.
  • HY-P7996
    PPAR alpha Protein, Human (His)

    PPARA, PPAR-α

    		Human E. coli
    PPAR alpha Protein, human (His), a member of the nuclear receptor family, is a transcription factor that regulates the expression of genes related to lipid metabolism in a ligand-dependent manner.
  • HY-P7999
    PPAR gamma Protein, Human (His)

    PPAR-γ-LBD

    		Human E. coli
    PPAR gamma LBD Protein, Human (His) is a His-fused PPAR-gamma-LBD protein expressed by E. coli, approximately 32.6 kDa. PPAR gamma LBD Protein can be used in the ligand screening assays, western blotting, and ELISA, et al.
  • HY-P70248
    ER alpha/ESR1 Protein, Human (His)

    rHuEstrogen receptor/ER alpha, His; Estrogen Receptor; ER; ER-Alpha; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A Member 1; ESR1; ESR; NR3A1

    		Human E. coli
    The ER α/ESR1 protein is a nuclear receptor that plays a critical regulatory role in gene expression, affecting cell proliferation and differentiation. Ligand-dependent transactivation involves binding of homodimers to estrogen response elements or association with transcription factors. ER alpha/ESR1 Protein, Human (His) is the recombinant human-derived ER alpha/ESR1 protein, expressed by E. coli , with N-6*His labeled tag.
  • HY-P70791
    ER beta/ESR2 Protein, Human (His)

    Estrogen Receptor Beta; ER-Beta; Nuclear Receptor Subfamily 3 Group A Member 2; ESR2; ESTRB; NR3A2

    		Human E. coli
    ER beta/ESR2 Protein, a nuclear hormone receptor, binds estrogens akin to ESR1/ER-alpha. It activates estrogen-dependent reporter genes with ERE. However, it lacks ligand binding ability and exhibits minimal ERE binding, resulting in the loss of ligand-dependent transactivation ability. ER beta/ESR2 Protein, Human (His) is the recombinant human-derived ER beta/ESR2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ER beta/ESR2 Protein, Human (His) is 323 a.a., with molecular weight of 35-40 kDa.
  • HY-P73701
    PPAR gamma Protein, Human (sf9, His-GST)

    CIMT1; GLM1; NR1C31; PPARG2; PPARG5; PPARgamma; PPARG

    		Human Sf9 insect cells
    The PPAR gamma protein is a nuclear receptor that binds to peroxisome proliferators and is activated upon ligand binding to specific PPREs on DNA. It regulates target gene transcription and controls fatty acid metabolism. PPAR gamma Protein, Human (sf9, His-GST) is the recombinant human-derived PPAR gamma protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
  • HY-P700275
    PPAR gamma Protein, Human (C-His)

    PPAR-γ-LBD

    		Human E. coli
    The PPAR gamma protein is a nuclear receptor that binds to peroxisome proliferators and is activated upon ligand binding to specific PPREs on DNA. It regulates target gene transcription and controls fatty acid metabolism. PPAR gamma Protein, Human (C-His) is the recombinant human-derived PPAR gamma protein, expressed by E. coli , with C-6*His labeled tag.
  • HY-P701106
    ER alpha/ESR1 Protein, Human (P. pastoris, N-His)

    rHuEstrogen receptor/ER alpha, His; Estrogen Receptor; ER; ER-Alpha; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A Member 1; ESR1; ESR; NR3A1

    		Human P. pastoris
    The ER α/ESR1 protein is a nuclear receptor that plays a critical regulatory role in gene expression, affecting cell proliferation and differentiation. Ligand-dependent transactivation involves binding of homodimers to estrogen response elements or association with transcription factors. ER alpha/ESR1 Protein, Human (P. pastoris, N-His) is the recombinant human-derived ER alpha/ESR1 protein, expressed by P. pastoris , with N-6*His labeled tag.
  • HY-P701404
    LXR-α Protein, Human

    NR1H3; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3

    		Human E. coli
    LXR-α protein is a nuclear receptor that activates transcription by interacting with RXR. It regulates cholesterol uptake through MYLIP-dependent ubiquitination and is critical for cholesterol homeostasis. LXR-α Protein, Human is the recombinant human-derived LXR-α protein, expressed by E. coli , with tag free. The total length of LXR-α Protein, Human is 266 a.a., .
  • HY-P702572
    PPAR gamma Protein, Human (P.pastoris, His)

    CIMT1, GLM1, NR1C31, PPARG2, PPARG5, PPARgamma, PPARG

    		Human P. pastoris
    The PPAR gamma protein is a nuclear receptor that binds to peroxisome proliferators and is activated upon ligand binding to specific PPREs on DNA. It regulates target gene transcription and controls fatty acid metabolism. PPAR gamma Protein, Human (P.pastoris, His) is the recombinant human-derived PPAR gamma protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of PPAR gamma Protein, Human (P.pastoris, His) is 477 a.a., with molecular weight of 56-60 kDa.
  • HY-P701336
    PPAR gamma Protein, Human

    PPARG; Peroxisome proliferator-activated receptor gamma; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3

    		Human E. coli
    The PPAR gamma protein is a nuclear receptor that binds to peroxisome proliferators and is activated upon ligand binding to specific PPREs on DNA. It regulates target gene transcription and controls fatty acid metabolism. PPAR gamma Protein, Human is the recombinant human-derived PPAR gamma protein, expressed by E. coli , with tag free. The total length of PPAR gamma Protein, Human is 272 a.a., .
  • HY-P701405
    LXR-α Protein, Human (His)

    NR1H3; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3

    		Human E. coli
    LXR-α protein is a nuclear receptor that activates transcription by interacting with RXR. It regulates cholesterol uptake through MYLIP-dependent ubiquitination and is critical for cholesterol homeostasis. LXR-α Protein, Human (His) is the recombinant human-derived LXR-α protein, expressed by E. coli , with N-6*His labeled tag. The total length of LXR-α Protein, Human (His) is 266 a.a., .
  • HY-P702843
    PPAR alpha Protein, Mouse (His)

    PPARA, PPAR-α

    		Mouse E. coli
    PPAR alpha Protein, Mouse (His), a member of the nuclear receptor family, is a transcription factor that regulates the expression of genes related to lipid metabolism in a ligand-dependent manner.
  • HY-P701402
    RXRB Protein, Human

    RXRB; Retinoic acid receptor RXR-beta; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta

    		Human E. coli
    RXRB protein is a receptor for retinoic acid and forms a heterodimer, especially RAR/RXR, which regulates gene expression through the retinoic acid response element (RARE). RXRB exhibits homodimerization and forms heterodimers with other retinoic acid receptor family members. RXRB Protein, Human is the recombinant human-derived RXRB protein, expressed by E. coli , with tag free. The total length of RXRB Protein, Human is 235 a.a., .
  • HY-P701403
    RXRB Protein, Human (His)

    RXRB; Retinoic acid receptor RXR-beta; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta

    		Human E. coli
    RXRB protein is a receptor for retinoic acid and forms a heterodimer, especially RAR/RXR, which regulates gene expression through the retinoic acid response element (RARE). RXRB exhibits homodimerization and forms heterodimers with other retinoic acid receptor family members. RXRB Protein, Human (His) is the recombinant human-derived RXRB protein, expressed by E. coli , with N-6*His labeled tag. The total length of RXRB Protein, Human (His) is 235 a.a., .
Cat. No. Product Name Effect Purity