Chemerin Receptor

Chemerin receptors are a type of membrane receptors that can specifically bind to chemerin and belong to the G-protein-coupled receptor family Class A. Currently, the main chemerin receptors include chemerin receptor 1, also known as ChemR23 or CMKLR1, and chemerin receptor 2, also known as GPR1. After chemerin binds to its receptor, it can recruit and activate immune cells, enhancing the body's innate and adaptive immune responses. At the same time, it can also regulate the functions of vascular endothelial cells and promote angiogenesis. Chemerin receptors are also involved in the regulation of energy metabolism and adipose tissue. Abnormalities in the expression and function of chemerin and its receptors are closely related to cancer, inflammatory diseases, and metabolic diseases such as obesity and diabetes^[1]^[2].

References:

[1]. Kennedy AJ, et al. International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) Nomenclature, Pharmacology, and Function. Pharmacol Rev. 2018 Jan;70(1):174-196. [Content Brief]

[2]. Zhang M, et al. G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery. Signal Transduct Target Ther. 2024 Apr 10;9(1):88. [Content Brief]

Chemerin Receptor Inhibitor (1)

Chemerin Receptor Related Products (6):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-138097

α-NETA		≥98.0%
α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC₅₀ of 9 μM. α-NETA is a potent ALDH1A1 (IC₅₀=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC₅₀=84 µM) and acetylcholinesterase (AChE; IC₅₀=300 µM). α-NETA has anti-cancer activity.

HY-P1844A

Chemerin-9 (149-157) (TFA)		98.22%
Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ_1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism.

HY-126536

ChemR23-IN-1		98.82%
ChemR23-IN-1 (compound 2) is a ChemR23 inhibitor with IC₅₀s of 38 nM and 100 nM for human and mouse ChemR23, respectively. ChemR23-IN-1 inhibits chemotaxis of CAL-1 triggered by Chemerin in vitro.

HY-P1844

Chemerin-9 (149-157)
Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ_1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism.

HY-P2712

Chemerin-9, mouse
Chemerin-9, mouse (Chemerin148-156, mouse) is a C-terminal nonapeptide of chemerin. Chemerin-9, mouse is a ligand for ChemR23 (EC₅₀ = 42 nM). Chemerin-9, mouse reduces basal lipolysis in primary mouse white adipocytes(IC₅₀ = 3.3 nM). Chemerin-9, mouse enhances memory and relieves Aβ1-42-induced memory impairment in AD mice. Chemerin-9, mouse also inhibits atherogenesis.

HY-145352

ChemR23-IN-2	Inhibitor
ChemR23-IN-2 is a potent and orally efficacious ChemR23 inhibitor with an IC₅₀ value of 3.2 nM.

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