2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. GDNF Receptor

GDNF Receptor

Glial-cell-line-derived neurotrophic factor receptor

Glial-cell-line-derived neurotrophic factor receptor (GDNF receptor) is a class of cell surface receptors that can specifically recognize and bind to GDNF. By binding to GDNF, it can initiate the intracellular signal transduction process, thereby regulating various biological functions of cells such as growth, differentiation, and survival. GDNF receptor can guide the migration and differentiation of neurons, facilitate the survival of neurons and axonal guidance, and is crucial for the construction of the nervous system. In addition, GDNF receptor has a neuroprotective effect, which can protect neurons from various damaging factors such as oxidative stress and inflammation, and enable neurons to resist degeneration. GDNF receptor is closely related to the degeneration of neurons in neurodegenerative diseases, also plays an important role in the repair of spinal cord and peripheral nerve injuries, and its abnormal expression is also associated with the occurrence, development, and metastasis of tumors such as neuroblastoma[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-111969
    BT18
    		99.77%
    BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function.
    BT18
  • HY-119910
    (E)-Aminoquinol
    		99.70%
    (E)-Aminoquinol (XIB4035) is a GFRα-1 agonist. (E)-Aminoquinol has mimic neurotrophic effects of GDNF, and induces Ret autophosphorylation in Neuro-2A cells. (E)-Aminoquinol can be used for research of Parkinson’s disease.
    (E)-Aminoquinol
  • HY-163840
    GFRα2/3-IN-1
    		Inhibitor
    GFRα2/3-IN-1 (Compound 16) is a selective GFRα2/3 inhibitor with IC50 values of 0.1 and 0.2 μM for GFRα2 and GFRα3, respectively. GFRα2 is a glial cell line-derived neurotrophic factor (GDNF) receptor related to GFRα1, GFRα2/3-IN-1 can be used for pain and itch research.
    GFRα2/3-IN-1
  • HY-119910B
    Aminoquinol phosphate
    		Agonist
    Aminoquinol ((E/Z)-XIB4035) phosphate is a GFRα-1 agonist. Aminoquinol phosphate exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol phosphate can be used in research related to Parkinson's disease.
    Aminoquinol phosphate
  • HY-119910C
    Aminoquinol triphosphate
    		Agonist
    Aminoquinol ((E/Z)-XIB4035) phosphate is a GFRα-1 agonist. Aminoquinol phosphate exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol phosphate can be used in research related to Parkinson's disease.
    Aminoquinol triphosphate
Cat. No. Product Name / Synonyms Application Reactivity