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Deubiquitinating enzymes (DUBs) are a large group of proteases that specifically remove ubiquitin (Ub) or ubiquitin-like proteins (UBLs) from of interest undergoing proteasomal degradation. The DUBs are classified into distinct families based on their sequence similarities and likely mechanisms of action, the vast majority of which are cysteine proteases. These include ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), ovarian tumor proteases (OTUs), Machado-Joseph disease proteases (MJDs), Jab1/Mov34/Mpr1 (JAMM) metalloproteases, and the recently-discovered MIU-containing novel DUB family, (MINDY) proteases. They regulate several cellular functions, including proteasome-dependent and lysosome-dependent proteolysis, gene expression, cell cycle progression, chromosome segregation, kinase activation, apoptosis, localization, DNA repair, maintenance of stemness, spermatogenesis, and degradation of signaling intermediates.
UCHL1 Protein, a ubiquitin carboxyl-terminal hydrolase, plays a crucial role in protein degradation and regulation of cellular processes.It is involved in maintaining neuronal integrity and has been linked to neurodegenerative diseases.UCHL1 Protein's potential as a biomarker and therapeutic target in neurodegenerative disorders makes it a subject of intense research in the field of neuroscience.UCHL1 Protein, Mouse (His) is the recombinant mouse-derived UCHL1 protein, expressed by E.coli , with N-His labeled tag.
USP5 protein selectively cleaves branched multiubiquitin polymers, favoring 'Lys-48'-linked polyubiquitin disassembly. It exhibits lower affinity for linear and 'Lys-63'-linked polyubiquitin. USP5 knockdown leads to p53/TP53 accumulation, enhancing p53/TP53 transcriptional activity, as unanchored polyubiquitin competes with ubiquitinated p53/TP53 for proteasomal recognition, unlike MDM2. USP5 Protein, Human (sf9, His) is the recombinant human-derived USP5 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of USP5 Protein, Human (sf9, His) is 835 a.a., with molecular weight of ~100 kDa.
USP14 is a proteasome-associated deubiquitinase that regulates ubiquitin dynamics by releasing ubiquitin from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment. USP14 Protein, Human (His) is the recombinant human-derived USP14 protein, expressed by E. coli , with N-6*His labeled tag. The total length of USP14 Protein, Human (His) is 404 a.a., with molecular weight of 47-52 kDa.
The UCHL1 protein is a ubiquitin proteolytic enzyme essential for processing ubiquitin precursors and hydrolyzing ubiquitinated proteins. As a thiol protease, it specifically cleaves the C-terminal glycine of ubiquitin. UCHL1 Protein, Rat (His) is the recombinant rat-derived UCHL1 protein, expressed by E. coli , with N-10*His labeled tag. The total length of UCHL1 Protein, Rat (His) is 222 a.a., with molecular weight of ~28 kDa.
USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9) is the recombinant human, mouse-derived USP46 protein, expressed by Sf9 insect cells , with tag free. The total length of USP46 Protein, Human/Mouse (sf9) is 366 a.a., with molecular weight of ~43 kDa.
UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is responsible for protein degradation and regulation of cellular processes. It is prominently expressed in the testes and plays a crucial role in spermatogenesis. UCHL3 Protein's involvement in male fertility and its potential as a therapeutic target in reproductive disorders make it a subject of interest in reproductive medicine. UCHL3 Protein, Human (His) is the recombinant human-derived UCHL3 protein, expressed by E. coli , with C-6*His labeled tag. The total length of UCHL3 Protein, Human (His) is 230 a.a., with molecular weight of ~25.0 kDa.
The USP7 protein is a hydrolase that deubiquitinates multiple targets, including FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5, and DAXX. It cooperates with DAXX to enhance the E3 ligase activity of MDM2 and promote ubiquitination and degradation of p53/TP53. USP7 Protein, Human (sf9) is the recombinant human-derived USP7 protein, expressed by Sf9 insect cells , with tag free. The total length of USP7 Protein, Human (sf9) is 353 a.a., with molecular weight of ~41 kDa.
OTUB1 protein directly interacts with RNF128, forming a ternary complex with USP8 through OTUB1's binding to the C-terminal UCH catalytic domain of USP8. OTUB1 Protein, Human (His) is the recombinant human-derived OTUB1 protein, expressed by E. coli , with N-His labeled tag.
The UCHL3 protein is a deubiquitinating enzyme (DUB) that complexly controls cellular ubiquitin levels by processing ubiquitin precursors and ubiquitinated proteins. As a thiol protease, UCHL3 selectively recognizes and hydrolyzes the peptide bond of ubiquitin or the C-terminal glycine of NEDD8, showing a 10-fold preference for Arg and Lys at the P3 position, and has a special preference for "Lys-48" linked ubiquitin chains. affinity. UCHL3 Protein, Rat (His) is the recombinant rat-derived UCHL3 protein, expressed by E. coli , with N-His labeled tag. The total length of UCHL3 Protein, Rat (His) is 229 a.a., with molecular weight of ~28 kDa.
OTUB2 is a hydrolase that efficiently removes conjugated ubiquitin from proteins in vitro, implying a crucial role in preventing protein degradation and regulating turnover. Its deubiquitinating activity targets “Lys-11”, “Lys-48” and “Lys-63” linked polyubiquitin chains, with preference for the latter. OTUB2 Protein, Human (His) is the recombinant human-derived OTUB2 protein, expressed by E. coli , with N-6*His labeled tag.
USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human is the recombinant human-derived USP46 protein, expressed by E. coli , with tag free. The total length of USP46 Protein, Human is 366 a.a., .
The USP47 protein is a ubiquitin-specific protease that deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizes POLB, and regulates base excision repair (BER). In addition to DNA repair, USP47 is an important regulator of cell growth and genome integrity. USP47 Protein, Human (Sf9, FLAG) is the recombinant human-derived USP47 protein, expressed by Sf9 insect cells , with C-Flag labeled tag. The total length of USP47 Protein, Human (Sf9, FLAG) is 1374 a.a., .
USP48 protein, a deubiquitinase, hydrolyzes ubiquitin bonds at the C-terminal Gly, processing poly-ubiquitin precursors and ubiquitinated proteins. It may regulate NF-kappa-B activation by the TNF receptor superfamily via RELA and TRAF2 interactions. With potential roles at postsynaptic sites, USP48 exhibits multifunctionality, influencing ubiquitin processing and signaling pathways involved in immune response and synaptic function. USP48 Protein, Human (Sf9, FLAG) is the recombinant human-derived USP48 protein, expressed by Sf9 insect cells , with C-Flag labeled tag. The total length of USP48 Protein, Human (Sf9, FLAG) is 1034 a.a., .
USP6 protein is an ATP-independent isopeptidase with unique deubiquitinase activity that can cleave the C-terminus of ubiquitin and catalyze its own deubiquitination. Notably, it coordinates ARF6 plasma membrane localization and selectively affects ARF6-dependent endocytic protein trafficking. USP6 Protein, Human (Sf9, GST) is the recombinant human-derived USP6 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of USP6 Protein, Human (Sf9, GST) is 878 a.a., .
The USP25 protein acts as a deubiquitinating enzyme and plays a key role in the hydrolysis of the ubiquitin moiety conjugated to the substrate. This function enables processing of newly synthesized ubiquitin, recycling of ubiquitin molecules, and editing of polyubiquitin chains, thus preventing proteasomal degradation of substrates. USP25 Protein, Human is the recombinant human-derived USP25 protein, expressed by E. coli , with tag free. The total length of USP25 Protein, Human is 1054 a.a., .
The USP28 protein serves as a deubiquitinase and plays a key role in the DNA damage response checkpoint and the stability of the MYC proto-oncogene. It selectively deubiquitinates DNA damage pathway proteins such as CLSPN, thereby regulating apoptosis. USP28 Protein, Human (Sf9) is the recombinant human-derived USP28 protein, expressed by Sf9 insect cells , with tag free. The total length of USP28 Protein, Human (Sf9) is 1076 a.a., .
The USP28 protein serves as a deubiquitinase and plays a key role in the DNA damage response checkpoint and the stability of the MYC proto-oncogene. It selectively deubiquitinates DNA damage pathway proteins such as CLSPN, thereby regulating apoptosis. USP28 Protein, Human (Sf9, His) is the recombinant human-derived USP28 protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of USP28 Protein, Human (Sf9, His) is 1076 a.a., .
USP30 protein is anchored on the outer mitochondrial membrane and severely inhibits mitophagy by antagonizing Parkin (PRKN). Hydrolyzing ubiquitin on RHOT1/MIRO1 and target proteins such as TOMM20 and USP30 blocks Parkin-mediated mitophagy, thereby regulating the clearance of damaged mitochondria. USP30 Protein, Human (Sf9) is the recombinant human-derived USP30 protein, expressed by Sf9 insect cells , with tag free. The total length of USP30 Protein, Human (Sf9) is 461 a.a., .
The USP11 protein is a multifunctional protease that selectively removes ubiquitin from target proteins and polyubiquitin chains, thereby hindering their proteasomal degradation. It shows a preference for “Lys-6” and “Lys-63” linked ubiquitin chains and less activity towards other linkages. USP11 Protein, Human (Sf9) is the recombinant human-derived USP11 protein, expressed by Sf9 insect cells , with tag free. The total length of USP11 Protein, Human (Sf9) is 962 a.a., .
