2. Recombinant Proteins
  3. Fc Receptors
  4. Fc Receptor-like Proteins

Fc Receptor-like Proteins

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Fc Receptor-like Proteins

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Fc receptor-like (FCRL) molecules, members of the immunoglobulin superfamily (IgSF), are preferentially expressed by B-cells and some T-cell subsets including CD4+ T-cells, CD8+ T-cells, NK cells, and dysfunctional population of CD4+ regulatory T-cells (Tregs). FCRLs have variable number of extracellular immunoglobulin-like domains and cytoplasmic activating ITAMs and/or inhibitory ITIMs. FCRLs share homology with conventional FcRs for IgG and IgE isotypes and are well-conserved between humans and nonhuman primates. FCRL1-5 could regulate different features of B-cell evolution such as development, differentiation, activation, antibody secretion and isotype switching.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P71565
    FCRL6 Protein, Human (His)

    Fc receptor homolog 6; Fc receptor-like 6; Fc receptor-like protein 6; Fc receptor-like protein 7; FcR-like protein 6; FcRH6; FcRL6; FCRL6_HUMAN; FLJ16056; IFGP6; IgSF type I transmembrane receptor; leukocyte receptor

    		Human E. coli
    The FCRL6 protein acts as a receptor for MHC class II and interacts with HLA-DR when specific beta chains are associated. Although independent stimulation of FCRL6 does not promote cytokine production or cytotoxic activity, it exhibits tyrosine phosphorylation interactions with proteins such as PTPN11, PTPN6, INPP5D, INPPL1, and GRB2. FCRL6 Protein, Human (His) is the recombinant human-derived FCRL6 protein, expressed by E. coli , with N-His labeled tag.
  • HY-P72655
    FCRL1 Protein, Human (HEK293, His)

    Fc receptor-like protein 1; FcRL1; FcRH1; hIFGP1; CD307a; FCRH1; IFGP1; IRTA5

    		Human HEK293
    The FCRL1 protein may act as an activation coreceptor in B cells, suggesting involvement in B cell activation and differentiation processes. The dual role of FCRL1 makes it a key player in regulating B cell responses and enhancing signaling pathways associated with B cell activation. FCRL1 Protein, Human (HEK293, His) is the recombinant human-derived FCRL1 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P72656
    FCRL1 Protein, Mouse (203a.a, HEK293, His)

    Fc receptor-like protein 1; FcRL1; FcRH1; hIFGP1; CD307a; FCRH1; IFGP1; IRTA5

    		Mouse HEK293
    Fc receptor-like protein 1 (Fcrl1) is a cell-surface membrane protein that belongs to FCRL family. Fcrl1 is a BCR co-receptor and enhance signaling through the B cell receptor. Fcrl1 promotes B cell proliferation and calcium mobilization. Fcrl1 is a biomarker and an important target in B cell lymphoproliferative disorders. FCRL1 Protein, Mouse (203a.a, HEK293, His) is the recombinant mouse-derived FCRL1 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P76924
    FCRL2 Protein, Human (HEK293, His)

    Fc receptor-like protein 2; FcRH2; CD307b; IFGP4; IRTA4; SPAP1

    		Human HEK293
    The FCRL2 protein regulates normal and neoplastic B cell development and has been shown to be involved in complex processes that control B cell maturation. Its tyrosine-phosphorylated isoform 2 interacts with PTPN6, suggesting the existence of a signaling pathway and emphasizing the role of this protein in cellular regulation. FCRL2 Protein, Human (HEK293, His) is the recombinant human-derived FCRL2 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P700302
    FcRH5/FcRL5 Protein, Human (HEK293, His)

    FcR-like protein 5; FcRH5; FcRL5; BXMAS1; CD307; CD307e; IFGP5

    		Human HEK293
    FcRH5/FcRL5 protein potentially plays a role in fertilization, engaging in intricate molecular pathways by interacting with signaling molecules such as PTPN6, PTPN11, SYK, and ZAP70. Its involvement in reproductive processes adds to its significance, and further exploration is needed to uncover its precise functions and molecular connections in the complex events of fertilization. FcRH5/FcRL5 Protein, Human (HEK293, His) is the recombinant human-derived FcRH5/FcRL5 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P76924A
    FCRL2 Protein, Human (HEK293, C-His)

    Fc receptor-like protein 2; FcRH2; CD307b; IFGP4; IRTA4; SPAP1

    		Human HEK293
    The FCRL2 protein regulates normal and neoplastic B cell development and has been shown to be involved in complex processes that control B cell maturation. Its tyrosine-phosphorylated isoform 2 interacts with PTPN6, suggesting the existence of a signaling pathway and emphasizing the role of this protein in cellular regulation. FCRL2 Protein, Human (HEK293, C-His) is the recombinant human-derived FCRL2, expressed by HEK293 , with C-6*His labeled tag. The total length of FCRL2 Protein, Human (HEK293, C-His) is 376 a.a.,
  • HY-P77651
    FcRH5/FcRL5 Protein, Human (HEK293, His-Avi)

    FcR-like protein 5; FcRH5; FcRL5; BXMAS1; CD307; CD307e; IFGP5

    		Human HEK293
    FcRH5/FcRL5 Protein, potentially impacting B-cell development and differentiation in peripheral lymphoid organs, serves as a marker for B-cell stages. It may have an immunoregulatory role in marginal zone B-cells and is suggested to play a role in fertilization. FcRH5/FcRL5 Protein, Human (HEK293, His-Avi) is the recombinant human-derived FcRH5/FcRL5 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FcRH5/FcRL5 Protein, Human (HEK293, His-Avi) is 836 a.a., with molecular weight of 95-115 kDa.
  • HY-P76923
    FCRL1 Protein, Mouse (Q8R4Y0-2, HEK293, His)

    Fc receptor-like protein 1; FcRL1; FcRH1; hIFGP1; CD307a; FCRH1; IFGP1; IRTA5

    		Mouse HEK293
    FCRL1 Protein, a potential activating coreceptor in B-cells, may play a role in B-cell activation and differentiation. Although the precise mechanisms are under investigation, FCRL1's presence suggests involvement in intricate signaling pathways associated with B-cell function and immune responses. FCRL1 Protein, Mouse (Q8R4Y0-2, HEK293, His) is the recombinant mouse-derived FCRL1 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P77652
    FcRH5/FcRL5 Protein, Mouse (HEK293, His)

    FcR-like protein 5; FcRH5; FcRL5; BXMAS1; CD307; CD307e; IFGP5

    		Mouse HEK293
    FcRH5/FcRL5 protein potentially plays a role in fertilization, engaging in intricate molecular pathways by interacting with signaling molecules such as PTPN6, PTPN11, SYK, and ZAP70. Its involvement in reproductive processes adds to its significance, and further exploration is needed to uncover its precise functions and molecular connections in the complex events of fertilization. FcRH5/FcRL5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FcRH5/FcRL5 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P702590
    FcRH5/FcRL5 Protein, Human (Biotinylated, HEK293, His-Avi)

    FcR-like protein 5; FcRH5; FcRL5; BXMAS1; CD307; CD307e; IFGP5

    		Human HEK293
    FcRH5/FcRL5 Protein, potentially impacting B-cell development and differentiation in peripheral lymphoid organs, serves as a marker for B-cell stages. It may have an immunoregulatory role in marginal zone B-cells and is suggested to play a role in fertilization. FcRH5/FcRL5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FcRH5/FcRL5, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of FcRH5/FcRL5 Protein, Human (Biotinylated, HEK293, His-Avi) is 836 a.a.,
Cat. No. Product Name Effect Purity