2. Signaling Pathways
  3. Autophagy
    PROTAC
  4. ATTECs

ATTECs

Autophagosome-tethering compounds

ATTECs

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Autophagosome-tethering compound (ATTEC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. ATTEC degrades target proteins by molecular glue mechanism, and its molecular weight is smaller than AUTAC. ATTEC shorten the distance between LC3 receptor and target protein and then the target protein was phagocytosed and transferred into lysosomal for degradation.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130258
    LC3-mHTT-IN-AN1 486443-73-6 98.99%
    LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
    LC3-mHTT-IN-AN1
  • HY-130259
    LC3-mHTT-IN-AN2 7758-73-8 98.12%
    LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
    LC3-mHTT-IN-AN2
  • HY-157458
    PDEδ autophagic degrader 1
    PDEδ autophagic degrader 1 (compound 12c), an autophagosome-tethering compound (ATTEC). is a potent PDEδ autophagic degrader. PDEδ autophagic degrader 1 reduces the PDEδ protein level through lysosome-mediated autophagy without affecting the PDEδ mRNA expression. PDEδ autophagic degrader 1 suppresses the growth in KRAS mutant pancreatic cancer cells.
    PDEδ autophagic degrader 1
  • HY-162588
    MC-ND-18
    MC-ND-18 is an ATTEC degrader of NLRP3 through autophagic mechanisms, with the DC50 of 125.5 nM in THP-1 cell. MC-ND-18 is composed of a NLRP3 ligand, linker and LC3 ligand.
    MC-ND-18
  • HY-162540
    LLC355
    LLC355 is a discoidin domain receptor 1 (DDR1) ATTEC degrader. LLC355 efficiently degrades DDR1 protein with a DC50 value of 150.8 nM in non-small cell lung cancer NCI-H23 cells. LLC355 induces DDR1 degradation via lysosome-mediated autophagy. LLC355 potently inhibits cancer cell tumorigenicity, migration, and invasion.
    LLC355
  • HY-147656
    NAMPT degrader-1 3011778-39-2
    NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency.
    NAMPT degrader-1
Cat. No. Product Name / Synonyms Application Reactivity