2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Carboxypeptidase

Carboxypeptidase

Carboxypeptidase

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Carboxypeptidase is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of aprotein or peptide. Contrast with an aminopeptidase, which cleaves peptide bonds at the other end of the protein. Humans, animals, and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation. Carboxypeptidases function involved in the indigestion of food, biosynthesis of neuroendocrine peptides, blood clotting, growth factor production, wound healing, reproduction, and many other processes.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100788
    2-PMPA
    		Inhibitor ≥98.0%
    2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM.
    2-PMPA
  • HY-103345
    2-MPPA
    		Inhibitor ≥98.0%
    2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM.
    2-MPPA
  • HY-W044764
    2-Benzylsuccinic acid
    		Inhibitor 99.41%
    2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an potent inhibitor of carboxypeptidase A (CPA).
    2-Benzylsuccinic acid
  • HY-W096171
    D-Dopa
    		Inhibitor
    D-Dopa is a non-competitive, allosteric inhibitor for glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa exhibits good pharmacokinetic characteristics, and low blood-brain barrier permeability in mouse model.
    D-Dopa
  • HY-70005
    CPA inhibitor
    		Inhibitor 99.93%
    CPA inhibitor (Carboxypeptidase inhibitor; compound 5) is a potent carboxypeptidase A (CPA) inhibitor with a Ki of 0.32 μM.
    CPA inhibitor
  • HY-122369
    Histargin
    		Inhibitor
    Histargin is a carboxypeptidase B inhibitor with IC50 of 17 μg/ml and ＞ 100 μg/ml aganist Carboxypeptidase B and Carboxypeptidase A, respectively. Histargin can be produced by actinomycetes.
    Histargin
  • HY-139840A
    GCPII-IN-1 TFA
    		Inhibitor 99.99%
    GCPII-IN-1 TFA is a glutamate carboxypeptidase II (GCPII, or PSMA) inhibitor scaffold with a Ki of 44.3 nM.
    GCPII-IN-1 TFA
  • HY-W704574
    Mergetpa
    		Inhibitor
    Mergetpa is a carboxypeptidase inhibitor used to block the conversion of kinins and B2 receptor antagonists to metabolites lacking the C-terminal arginine.
    Mergetpa
  • HY-137840
    Hippuryl-L-phenylalanine
    		98.21%
    Hippuryl-L-phenylalanine is a substrate of carboxypeptidase. Carboxypeptidase is a protease enzyme that related with obesity, epilepsy and neurodegeneration. Hippuryl-L-phenylalanine can be used for the determination of carboxypeptidase activity.
    Hippuryl-L-phenylalanine
  • HY-70003
    Carboxypeptidase G2 (CPG2) Inhibitor
    		Inhibitor 98.03%
    Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.
    Carboxypeptidase G2 (CPG2) Inhibitor
  • HY-100788C
    2-PMPA sodium
    		Inhibitor
    2-PMPA sodium is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM.
    2-PMPA sodium
  • HY-P2981
    Carboxypeptidase C
    Carboxypeptidase C is a carboxypeptidase, is often used in biochemical studies. Carboxypeptidase C removes COOH-terminal lysine, arginine, and proline, as well as all other neutral, aliphatic, aromatic, and the acidic protein amino acids of a peptide chain.
    Carboxypeptidase C
  • HY-P10231
    Ac-Phe-Thiaphe-OH
    Ac-Phe-Thiaphe-OH is a modified peptide, which is utilized as substrate for carboxypeptidase A (CPA).
    Ac-Phe-Thiaphe-OH
  • HY-139840
    GCPII-IN-1
    		Inhibitor 99.83%
    GCPII-IN-1 is a glutamate carboxypeptidase II (GCPII, or PSMA) inhibitor scaffold with a Ki of 44.3 nM.
    GCPII-IN-1
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity