2. Recombinant Proteins
  3. Viral Proteins
  4. Hepatitis C Virus Proteins

Hepatitis C Virus Proteins

Recombinant Protein Expression Service

Hepatitis C Virus Proteins

Related Products

XLSX 3.95 KB

Hepatitis C virus (HCV) is a positive-strand RNA virus grouped in the genus Hepacivirus within the family Flaviviridae. HCV is classified into at least 6 genotypes (gt), and its error-prone polymerase leads to more than 50 subtypes. The long open reading frame, which encodes the HCV polyprotein, is processed by host and viral proteases and gives rise to three structural proteins (the capsid protein core and envelope glycoproteins E1 and E2) and seven nonstructural (NS) proteins (p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B). NS2 and p7 are essential for virus assembly but not RNA replication, whereas NS3 to NS5B are involved in a membrane-associated RNA replicase complex (RC). The NS3 protein is composed of a serine protease and an RNA helicase/nucleoside triphosphatase (NTPase), NS4A serves as a cofactor for NS3 serine protease, NS5B is the RNA-dependent RNA polymerase, and NS5A is considered to play key roles in multiple steps of the HCV life cycle.NS5A inhibitors exhibit a rapid inhibition of virus infectivity shortly after administration to HCV-infected cells. The HCV protein NS5A prevents the apoptosis-enabling loss of intracellular potassium by inhibiting Kv2.1 function and thus blocking hepatocyte cell death. The HCV RNA-dependent RNA polymerase (RdRp) has long been a prime target for antiviral development because of its critical role in viral replication and the absence of a mammalian homologous enzyme. The combination of lucidone and alpha interferon, the protease inhibitor Telaprevir, the NS5A inhibitor BMS-790052, or the NS5B polymerase inhibitor PSI-7977, synergistically suppresses HCV RNA replication.

Subscribe Now to the List of Recombinant Proteins

 
Cat. No. Product Name / Synonyms Species Source
  • HY-P74183
    E2/Envelope Protein, Hepatitis C virus (AAC15723, HEK293, His)

    HCV-1a E2 Protein; Hepatitis C virus (serotype 1b, isolate HC-J4) Envelope/E2 Protein

    		Virus HEK293
    E2/Envelope Protein, Hepatitis C virus (AAC15723, HEK293, His) is the recombinant Virus-derived E2/Envelope protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P74184
    E2/Envelope Protein, Hepatitis C virus (BAA03581, HEK293, His)

    Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His Tag); HCV-1a E2 Protein

    		Virus HEK293
    E2/Envelope Protein, Hepatitis C virus (BAA03581, HEK293, His) is the recombinant Virus-derived E2/Envelope protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P74185
    E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His)

    Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His Tag); HCV-1a E2 Protein

    		Virus HEK293
    E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His) is the recombinant Virus-derived E2/Envelope protein, expressed by HEK293 , with C-His labeled tag. The total length of E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His) is 278 a.a., with molecular weight of ~32 kDa.
  • HY-P74898
    NS3 protease Protein, HCV (GST)

    Hepatitis C virus (HCV-1a) NS3 protease / helicase immunodominant region Protein ( GST)

    		Virus E. coli
    NS3 protease Protein is a zinc-dependent serine protease.NS3 needs to bind to the viral protein NS4A to enable additional conformation changes that enhance activity and appropriate intracellular localization.NS3 protein induces Caspase-8-mediated apoptosis independently of its protease or helicase activity.NS3 protease Protein, HCV (GST) is the recombinant Virus-derived NS3 protease protein, expressed by E.coli , with N-GST labeled tag.
  • HY-P74899
    Envelope Glycoprotein E1 Protein, HCV (HEK293, His)

    HCV-E1 Protein; Hepatitis C virus Envelope Glycoprotein E1 / HCV-E1 (subtype 1b, strain HC-J4) Protein

    		Virus HEK293
    Envelope Glycoprotein E1 Protein, one of two subunits of the envelope glycoprotein found in the hepatitis C virus, is a type 1 transmembrane protein.It associates with envelope glycoprotein E2 as a noncovalent heterodimer, which mediates virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane.E1/E2 heterodimer binds host apolipoproteins.And it also binds to CD81 and activates the epithelial growth factor receptor (EGFR) signaling pathway.Envelope Glycoprotein E1 Protein, HCV (HEK293, His) is the recombinant Virus-derived Envelope Glycoprotein E1 protein, expressed by HEK293 , with N-His labeled tag.
Cat. No. Product Name Effect Purity