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Fluorescent-labeled proteins are protein molecules that covalently binding with fluorescent dyes. The fluorescent label (fluorescent tag, fluorescent probe) generally acts as a tool to investigate conformational dynamics and molecular interactions or track the movement of proteins in order to gain insight into their biological functions. + Fluorescent assays can be performed in real-time, in solution, with high-time resolution and sensitivity down to single molecules.
Mesothelin Protein, especially in its membrane-anchored forms, potentially mediates cellular adhesion, implicating its role in cell interactions. Furthermore, the associated Megakaryocyte-potentiating factor (MPF) actively enhances in vitro megakaryocyte colony formation, indicating its participation in fostering specialized blood cell colonies' development. FITC-Labeled Mesothelin Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled Mesothelin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FITC-Labeled Mesothelin Protein, Human (HEK293, Fc) is 285 a.a., with molecular weight of 70-80 kDa.
Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. FITC-Labeled Angiopoietin-2 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of FITC-Labeled Angiopoietin-2 Protein, Human (HEK293, His) is 222 a.a., with molecular weight of 30-40 kDa.
Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein, as cells overexpressing mesothelin have altered adhesive properties. Mesothelin is also a Megakaryocyte-potentiating factor (MPF) which potentiates megakaryocyte colony formation in vitro. Mesothelin may be related to cancer metastasis. PE-Labeled Mesothelin Protein, Human (HEK293, His) is the recombinant human-derived PE-Labeled Mesothelin protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of PE-Labeled Mesothelin Protein, Human (HEK293, His) is 285 a.a., with molecular weight of 35.9 kDa.
CD47 is an adhesion protein that regulates integrin signaling through G protein activation and serves as a receptor for thrombospondin THBS1, affecting signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, self-renewal and Immunomodulatory. It regulates pulmonary endothelin EDN1 signaling, acts as a pressor in blood pressure regulation, and is critical for memory formation. FITC-Labeled CD47 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled CD47 protein, expressed by HEK293 , with His labeled tag. The total length of FITC-Labeled CD47 Protein, Human (HEK293, His) is 121 a.a., with molecular weight of 35-45 kDa.
CEACAM5 protein is a cell surface glycoprotein that cooperates with carcinoembryonic antigen-related molecules (such as CEACAM6) to participate in cell adhesion, intracellular signaling, and tumor progression. FITC-Labeled CEACAM5 Protein, Human (HEK293, His, Avi) is the recombinant human-derived FITC-Labeled CEACAM5 protein, expressed by HEK293 , with His and Avi labeled tag.
VEGF145 Protein, with limited expression, exhibits specialized distribution and is not broadly present in tissues. Its restricted occurrence implies a specific, context-dependent role in physiological processes. Further research is needed to unveil the specific cellular contexts and functions where VEGF145 actively participates, providing insights into its potential contributions to localized biological activities. FITC-Labeled VEGF165 Protein, Human (HEK293, C-His) is the recombinant human-derived FITC-Labeled VEGF165 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of FITC-Labeled VEGF165 Protein, Human (HEK293, C-His) is 165 a.a., with molecular weight of 27-33 kDa.
HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. FITC-labeled HER3 Protein, Human (HEK293, His) is the recombinant human-derived FITC-labeled HER3 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.
The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells. It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses. FITC-Labeled NKG2D/CD314 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled NKG2D/CD314 protein, expressed by HEK293 , with N-hFc, N-Flag labeled tag. The total length of FITC-Labeled NKG2D/CD314 Protein, Human (HEK293, Fc) is 139 a.a., with molecular weight of 50-70 kDa.
Basigin/BSG proteins are critical for retinal maturation and development and function as retinal cell receptors for NXNL1, promoting the survival of retinal cone photoreceptors. FITC-Labeled Basigin/CD147 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled Basigin/CD147 protein, expressed by HEK293 , with His labeled tag. The total length of FITC-Labeled Basigin/CD147 Protein, Human (HEK293, His) is 184 a.a., with molecular weight of 28-40 kDa.
The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. PE-labeled Glypican-3/GPC3 Protein, Human (HEK293, His) is the recombinant human-derived PE-labeled Glypican-3/GPC3 protein, expressed by HEK293 , with His labeled tag.
CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. FITC-Labeled CD276/B7-H3 Protein, Human (435a.a, HEK293, Fc) is the recombinant human-derived FITC-Labeled CD276/B7-H3 protein, expressed by HEK293 , with Fc labeled tag.
The green fluorescent protein (GFP), Aequorea victoria is a protein that exhibits green fluorescence when exposed to light in the blue to ultraviolet range, found in organisms including Aequorea victoria, corals, sea anemones, zoanithids, copepods and lancelets. GFP Protein has a major excitation peak at a wavelength of 395 nm and a minor one at 475 nm, while its emission peak is at 509 nm, which is in the lower green portion of the visible spectrum. GFP Protein acts as an energy transfer receptor and actively transduces the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer, which is used as expression of reporter genes. GFP Protein, Aequorea victoria (His) is a recombinant jellyfish Aequorea victoria GFP protein with N-6*His labeled tag that consists of 238 amino acids, which is expressed in E. coli .
C-type lectin domain family 12 member A; CLL-1; DCAL-2; MICL; CD371
Human
HEK293
CLEC12A/MICL (C-type lectin domain family 12 member A/myelosuppressive C-type lectin-like receptor) is a cell surface receptor that acts as a modulator of signaling cascades, specifically promoting target MAP kinases Protease. FITC-Labeled CLEC12A/MICL Protein, Human (HEK293, His, solution) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293 , with N-His labeled tag.
The TROP-2 protein emerged as a potential growth factor receptor, implying involvement in cellular processes related to growth and signaling. As a putative receptor, TROP-2 may play a crucial role in transducing signals that regulate cell growth and proliferation. TROP-2 Protein, Human (FITC, HEK293, His) is the recombinant human-derived TROP-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of TROP-2 Protein, Human (FITC, HEK293, His) is 248 a.a., with molecular weight of 45-50 kDa.
The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). FITC-Labeled CD38 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled CD38 protein, expressed by HEK293 , with C-His labeled tag. The total length of FITC-Labeled CD38 Protein, Human (HEK293, His) is 258 a.a., with molecular weight of 40-50 kDa.
CD19 Protein, a B-cell antigen receptor coreceptor, enhances downstream signaling pathways, lowers activation threshold, and aids B-cell responses to antigens. It activates phosphatidylinositol 3-kinase and mobilizes intracellular Ca(2+). CD19 is essential for B-1 cell differentiation and influences B cell proliferation, immunoglobulin levels, and high-affinity antibody production. It complexes with CD21, CD81, and CD225, interacts with CD81 for receptor trafficking, and binds to VAV, GRB2, SOS, PLCG2, LYN, and p85 subunit of phosphatidylinositol 3-kinase when phosphorylated. CD19 Protein, Human (FITC, HEK293, His) is the recombinant human-derived CD19 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD19 Protein, Human (FITC, HEK293, His) is 272 a.a., with molecular weight of 68-72 kDa.
Mesothelin Protein, especially in its membrane-anchored forms, potentially mediates cellular adhesion, implicating its role in cell interactions. Furthermore, the associated Megakaryocyte-potentiating factor (MPF) actively enhances in vitro megakaryocyte colony formation, indicating its participation in fostering specialized blood cell colonies' development. FITC-Labeled Mesothelin Protein, Human (HEK293, His-Avi) is the recombinant human-derived FITC-Labeled Mesothelin protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FITC-Labeled Mesothelin Protein, Human (HEK293, His-Avi) is 285 a.a., with molecular weight of 40-50 kDa.
The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR vIII Protein, Human (FITC, HEK293, His-Avi) is the recombinant human-derived EGFR vIII protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (FITC, HEK293, His-Avi) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of EGFR Protein, Human (FITC, HEK293, His-Avi) is 621 a.a., with molecular weight of 90-115 kDa.
The LILRB4/CD85k/ILT3 protein is a key inhibitory receptor that plays a key role in immune regulation and tolerance. As a receptor for FN1, apolipoprotein APOE, and ALCAM/CD166, it inhibits receptor-mediated phosphorylation, intracellular calcium mobilization, and FCGR1A/CD64-mediated monocyte activation, thereby reducing TNF production. FITC-Labeled LILRB4/CD85k/ILT3 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled LILRB4/CD85k/ILT3 protein, expressed by HEK293 , with C-His labeled tag.
