2. Signaling Pathways
  3. Immunology/Inflammation
  4. CD22

CD22

Siglec 2

CD22 (Siglec 2) is a 135-kDa B-cell restricted antigen, and is an inhibitory coreceptor of the B-cell receptor (BCR). The extracellular portion of CD22 comprises seven immunoglobulin domains, and is responsible for binding α2,6Sia ligands. Interaction with these ligands in cis (on the B-cell surface) regulates the association of CD22 with the BCR and thereby modulates the inhibitory function of CD22. Interaction of CD22 to ligands in trans (on the surface of other cells) can regulate both B-cell migration as well as the BCR signaling threshold.
CD22 can also recruit the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits BCR-induced Ca2+ signaling on normal B cells. CD22 is critical in maintaining a baseline level of B-cell inhibition and homeostasis in humoral immunity. CD22 is a target molecule in dysregulated B cells that cause autoimmune diseases and blood cancers[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P99264
    Inotuzumab
    		Inhibitor
    Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) is a humanized IgG4, κ antibody that targets human CD22. Inotuzumab can be linked to a toxic agent ozogamicin as an antibody-drug conjugate (ADC). Inotuzumab can be used for the research of acute lymphoblastic leukemia and non-Hodgkin lymphoma.
    Inotuzumab
  • HY-P99289
    Epratuzumab
    Epratuzumab (Antibody hLL 2) is an anti-CD22 IgG1 monoclonal antibody. Epratuzumab is also a tumor-imaging agent and an immunomodulatory agent. Epratuzumab can induce CD22 phosphorylation. Epratuzumab has been used to research non-Hodgkin’s lymphomas (NHL) and certain autoimmune diseases.
    Epratuzumab
  • HY-P99034
    Moxetumomab
    		Inhibitor
    Moxetumomab, a recombinant CD22-targeting immunotoxin, can be used for the research of hairy cell leukemia (HCL).
    Moxetumomab
  • HY-P990781
    Suciraslimab
    Suciraslimab is an anti-CD22 human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
    Suciraslimab
  • HY-P99230
    Pinatuzumab
    		Inhibitor
    Pinatuzumab is a CD22 monoclonal antibody. Pinatuzumab targets the cell-surface antigen CD22. Pinatuzumab can be used for synthesis of antibody agent conjugates (ADCs) to research several diseases including non-Hodgkin lymphoma (NHL).
    Pinatuzumab
  • HY-P990759
    Rezetamig
    Rezetamig is an anti-CD3E/CD22 monoclonal antibody.
    Rezetamig
  • HY-164761
    Anti-CD22-NMS249
    		Inhibitor
    Anti-CD22-NMS249 is a CD22-targeting antibody-drug conjugate (ADC). Anti-CD22-NMS249 is composed of a humanized anti-CD22 antibody Pinatuzumab (HY-P99230), a cleavable linker (Mc-VC-PAB), and a DNA topoisomerase II inhibitor payload PNU-159682 (HY-16700). Anti-CD22-NMS249 can be used for research in non-Hodgkin lymphoma (NHL).
    Anti-CD22-NMS249
  • HY-P99255
    Moxetumomab pasudotox
    		Inhibitor
    Moxetumomab pasudotox (CAT 8015) is anti-CD22 immunotoxin containing an anti-CD22 Fv and Pseudomonas exotoxin. CD22 is a cell surface receptor expressed on a variety of malignant B-cells. Moxetumomab pasudotox can be used in the research of hairy cell leukemia (HCL).
    Moxetumomab pasudotox
  • HY-146081
    CD22 ligand-1
    CD22 ligand-1 (compound 12) is a potent and selective CD22 ligand with KD of 0.335, 30.7 µM for hCD22 and MAG, respectively. CD22 ligand-1 has the potential for the research of B-cell related disease.
    CD22 ligand-1
  • HY-P99464
    Bectumomab
    Bectumomab (IMMU-LL 2) is an humanized IgG2a mAb against human CD22 (antigen). Bectumomab is also an anti-lymphoma antibody fragment. Bectumomab can be used for imaging in combination with technetium 99 (Tc99m LL2 Fab). Moreover, Bectumomab examines in the staging of recurrent or newly diagnosed non-Hodgkin's lymphoma (NHL) and to assess targeting before radioimmunoresearch (RIT).
    Bectumomab
Cat. No. Product Name / Synonyms Application Reactivity