Sirtuin

Sirtuin Isoform Specific Products:

Sirtuin Related Products (211)
Antibodies (9)
Sirtuin Isoform Comparison

By Effects:	Inhibitors (127) Agonists (3) Degrader (1) Activators (58) Modulators (9)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B0150

Nicotinamide	Inhibitor	99.99%
Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC₅₀: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD₊, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity.

HY-16561

Resveratrol	Activator	99.94%
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.

HY-15452

Selisistat	Inhibitor	99.87%
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC₅₀ of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease.

HY-123033A

Nicotinamide riboside chloride	Activator	99.90%
Nicotinamide riboside Chloride, an orally active NAD⁺ precursor, increases NAD⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

HY-108331

3-TYP	Inhibitor	99.96%
3-TYP is an inhibitor of SIRT3 (IC₅₀of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases.

HY-169934

SIRT1-IN-4	Inhibitor
SIRT1-IN-4 (Compound 8c) is a SIRT1 inhibitor, with an IC₅₀ of 10.04 μM. SIRT1-IN-4 can be used for the research of cancer.

HY-173463

Sirtuin modulator 8	Modulator
Sirtuin modulator 8 is a sirtuin modulator that can activate Sirtuin activity. Sirtuin modulator 8 significantly downregulates the expression of monocyte chemoattractant protein-1 (MCP-1) and upregulates the expression of fibroblast growth factor 21 (FGF21). Sirtuin modulator 8 regulates the expression of inflammation- and metabolism-related genes, showing potential for studying metabolic diseases (such as diabetes, obesity) and inflammatory diseases.

HY-172204

SIRT-IN-7	Inhibitor
SIRT-IN-7 (Compound 7ba) is a SIRT inhibitor. SIRT-IN-7 can inhibit the expression of SIRT1, SIRT2, and SIRT3, and increase the acetylation and activation of p53. SIRT-IN-7 can inhibit the proliferation, and induce apoptosis and autophagy of breast cancer cells. SIRT-IN-7 has anti-tumor activity.

HY-N0182

Fisetin	Activator	99.99%
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

HY-B0879A

Suramin sodium salt	Inhibitor	99.48%
Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM). Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM). Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor. Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent.

HY-10532

SRT 1720	Activator	99.90%
SRT 1720 is a selective activator of human SIRT1 with an EC_1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC_1.5s of 37 μM and > 300 μM, respectively.

HY-107454

OSS_128167	Inhibitor	98.63%
OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC₅₀s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects.

HY-100578

AGK2	Inhibitor	99.62%
AGK2 is a selective SIRT2 inhibitor with an IC₅₀ of 3.5 μM. AGK2 inhibits SIRT1 and SIRT3 with IC₅₀s of 30 and 91 μM, respectively.

HY-15262

SRT 2104	Activator	99.00%
SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD⁺ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease.

HY-112587

MC3482	Inhibitor	99.22%
MC3482 is a specific sirtuin5 (SIRT5) inhibitor.

HY-13515

Sirtinol	Inhibitor	≥98.0%
Sirtinol is a sirtuin (SIRT) inhibitor, with IC₅₀s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.

HY-15145

SRT 1720 monohydrochloride	Activator	99.92%
SRT 1720 monohydrochloride is a selective and orally active activator of SIRT1 with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.

HY-115453

UBCS039	Activator	99.06%
UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC₅₀ of 38 μM.

HY-135899

SIRT7 inhibitor 97491	Inhibitor	98.81%
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC₅₀ of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway..

HY-101278

Thiomyristoyl	Inhibitor	99.74%
Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC₅₀ of 28 nM.

Nicotinamide		SIRT1, IC₅₀: 50-180 μM	SIRT2, EC₅₀: 2 μM					99.99%
Nicotinamide riboside chloride		SIRT1		SIRT3				99.90%
3-TYP				SIRT3, IC₅₀: 38 μM				99.96%
SIRT1-IN-4		SIRT1, IC₅₀: 10.04 μM
Suramin sodium salt		SIRT1, IC₅₀: 297 nM	SIRT2, IC₅₀: 1.15 μM			SIRT5, IC₅₀: 22 μM		99.48%
SRT 1720		SIRT1, EC1.5: 0.16 μM	SIRT2, EC1.5: 37 μM					99.90%
OSS_128167		SIRT1, IC₅₀: 1578 μM	SIRT2, IC₅₀: 751 μM		SIRT6, IC₅₀: 89 μM			98.63%
AGK2		SIRT1, IC₅₀: 30 μM	SIRT2, IC₅₀: 3.5 μM	SIRT3, IC₅₀: 91 μM				99.62%
SRT 2104		SIRT1						99.00%
Sirtinol		ySir2, IC₅₀: 48 μM hSIRT1, IC₅₀: 131 μM	hSIRT2, IC₅₀: 57.7 μM					≥98.0%
SRT 1720 monohydrochloride		SIRT1, EC1.5: 0.16 μM SIRT1, EC₅₀: 0.10 μM	SIRT2, EC1.5: 37 μM					99.92%
UBCS039					SIRT6, EC₅₀: 38 μM			99.06%
SIRT7 inhibitor 97491							SIRT7, IC₅₀: 325 nM	98.81%
Thiomyristoyl		SIRT1, IC₅₀: 98 μM	SIRT2, IC₅₀: 28 nM					99.74%
Resveratrol (Standard)	Sirtuin							99.73%
SRT 1460		SIRT1, EC1.5: 2.9 μM						98.16%
SirReal2			SIRT2, IC₅₀: 140 nM					≥99.0%
Cambinol		SIRT1, IC₅₀: 56 μM	SIRT2, IC₅₀: 59 μM					99.89%
AK-7			SIRT2, IC₅₀: 15.5 μM					99.63%
Ganoderic acid D				SIRT3				99.40%
SIRT6 activator 12q					SIRT6, EC1.5: 0.58 μM			98.01%
SRT 1720 dihydrochloride		SIRT1, EC₅₀: 0.10 μM						99.13%
Agrimol B		SIRT1						99.75%
Tenovin-6		SIRT1, IC₅₀: 21 μM	SIRT2, IC₅₀: 10 μM	SIRT3, IC₅₀: 67 μM				98.33%
Perindopril erbumine				SIRT3				99.98%
Inauhzin		SIRT1						99.49%
SRT 2183		SIRT1, EC1.5: 0.36 μM						98.06%
Tenovin-1	Sirtuin							99.88%
Scopolin		SIRT1						99.93%
SIRT1-IN-1		SIRT1, IC₅₀: 0.205 μM	SIRT2, IC₅₀: 11.5 μM	SIRT3, IC₅₀: >100 μM				98.19%
CAY10602		SIRT1						98.65%
Perindopril				SIRT3				98.11%
SIRT5 inhibitor 3						SIRT5, IC₅₀: 5.9 μM		≥98.0%
Et-29						SIRT5, Ki: 40 nM		99.89%
Salermide		SIRT1	SIRT2					≥98.0%
SIRT-IN-2		SIRT1, IC₅₀: 4 nM	SIRT2, IC₅₀: 1 nM	SIRT3, IC₅₀: 7 nM				98.08%
Dihydrocoumarin		hSIRT1, IC₅₀: 208 μM	hSIRT2, IC₅₀: 295 μM					99.81%
PROTAC Sirt2 Degrader-1			SIRT2, IC₅₀: 0.25 μM					98.71%
E1231		SIRT1, EC₅₀: 0.83 μM						98.55%
SIRT1-IN-2		SIRT1, IC₅₀: 1.6 μM	SIRT2, IC₅₀: 39 μM					98.86%
Tenovin-6 Hydrochloride		SIRT1, IC₅₀: 21 μM	SIRT2, IC₅₀: 10 μM	SIRT3, IC₅₀: 67 μM				98.88%
Segetalin B		SIRT1						99.51%
Nicotinamide (Standard)			SIRT2					99.85%
5-Heptadecylresorcinol				SIRT3				99.83%
AK-1			SIRT2, IC₅₀: 12.5 μM					99.97%
Gardenia yellow				SIRT3
Sirtuin-1 inhibitor 1		SIRT1						98.09%
SIRT-IN-1		SIRT1, IC₅₀: 15 nM	SIRT2, IC₅₀: 10 nM	SIRT3, IC₅₀: 33 nM				98.14%
(S)-Selisistat		SIRT1, IC₅₀: 98 nM						99.39%
SIRT2-IN-8			SIRT2					99.32%
YK-3-237		SIRT1						99.54%
SIRT3 activator 2				SIRT3				98.94%
Lumbokinase		SIRT1
SIRT2-IN-9		SIRT1, IC₅₀: ＞300 μM	SIRT2, IC₅₀: 1.3 μM	SIRT3, IC₅₀: ＞300 μM				99.45%
SIRT1-IN-3		SIRT1, IC₅₀: 4.2 μM	SIRT2, IC₅₀: 38 μM					99.18%
Sirt2-IN-1			SIRT2, IC₅₀: 163 nM					98.71%
Tanshindiol C		SIRT1						98.47%
Suramin		SIRT1, IC₅₀: 297 nM	SIRT2, IC₅₀: 1.15 μM			SIRT5, IC₅₀: 22 μM
SIRT2-IN-11		SIRT1, IC₅₀: 118.4 μM	SIRT2, IC₅₀: 18.5 μM					99.94%
RK-9123016			SIRT2, IC₅₀: 0.18 μM					99.02%
JGB1741		SIRT1, IC₅₀: ∼15 μM	SIRT2, IC₅₀: >100 μM	SIRT3, IC₅₀: >100 μM				99.05%
SIRT6-IN-3		SIRT1, IC₅₀: 80.52 μM	SIRT2, IC₅₀: 92.21 μM		SIRT6, IC₅₀: 7.46 μM			98.19%
AC-93253		SIRT1, IC₅₀: 45.3 μM	SIRT2, IC₅₀: 6 μM	SIRT3, IC₅₀: 24.6 μM
MIND4-19			SIRT2, IC₅₀: 7.0 μM					99.93%
Sirtuin modulator 1		SIRT1, EC1.5: 1 μM						99.85%
Ophiopogonin D'		SIRT1						99.85%
CrBKA					SIRT6			98.46%
Nicotinamide riboside		SIRT1		SIRT3
CHIC35		SIRT1, IC₅₀: 0.124 μM	SIRT2, IC₅₀: 2.8 μM	SIRT3, IC₅₀: >100 μM
SIRT1/2/3-IN-2		SIRT1	SIRT2	SIRT3
Sirt2-IN-5			SIRT2
SPC-180002		SIRT1, IC₅₀: 1.13 ± 0.3 μM		SIRT3, IC₅₀: 5.41 ± 4.8 μM
Epigenetic factor-IN-1							SIRT7
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol		SIRT1
SirReal-1			SIRT2, IC₅₀: 3.7 μM
Sirt2-IN-6			SIRT2, IC₅₀: 0.815 μM
Nicotinamide Hydrochloride		SIRT1, IC₅₀: 50-180 μM	SIRT2, EC₅₀: 2 μM
hsa62		SIRT1, IC₅₀: 1.3 μM	SIRT2, IC₅₀: 5.5 μM	SIRT3, IC₅₀: 43.6 μM
DCHC		SIRT1
C1A				SIRT3, IC₅₀: 55 μM
SIRT5 inhibitor 5						SIRT5, IC₅₀: 0.21 μM
SIRT5 inhibitor 4		SIRT1, IC₅₀: ＞400 μM	SIRT2, IC₅₀: ＞400 μM	SIRT3, IC₅₀: ＞400 μM	SIRT6, IC₅₀: ＞400 μM	SIRT5, IC₅₀: 26.4 μM	SIRT7, IC₅₀: ＞400 μM
Nicotinamide riboside tartrate		SIRT1		SIRT3
SIRT6 activator 2					SIRT6
Sirt1/2-IN-1		SIRT1, IC₅₀: 1.81 μg/mL	SIRT2, IC₅₀: 2.10 μg/mL	SIRT3, IC₅₀: 20.5 μg/mL
Sirtuin modulator 4		SIRT1, EC₅₀: 51-100 μM
SIRT1-IN-5		SIRT1
SIRT2-IN-14		SIRT1, IC₅₀: >200 μM	SIRT2, IC₅₀: 0.196 μM	SIRT3, IC₅₀: 85.8 μM
Nicotinamide riboside malate		SIRT1		SIRT3
SIRT5 inhibitor 2						SIRT5, IC₅₀: 2.3 μM
Sirtuin modulator 5		SIRT1, DC₅₀: ＜50 μM
Sirtuin-IN-2						SIRT5
SR94			SIRT2
HSP70/SIRT2-IN-1			SIRT2, IC₅₀: 17.3±2.0 μM
SIRT3-IN-1				SIRT3, IC₅₀: 0.043 μM
FLS-359			SIRT2, IC₅₀: 3 μM
SIRT6-IN-4		SIRT1, IC₅₀: 311.9 μM	SIRT2, IC₅₀: 157.2 μM	SIRT3, IC₅₀: 274.1 μM	SIRT6, IC₅₀: 5.86 μM
YZL-51N							SIRT7, IC₅₀: 12.71 μM
Cudraflavone B		SIRT1
ZINC08792229		SIRT1
SIRT3-IN-2				SIRT3
A2B57			SIRT2, IC₅₀: 6.3 μM
SIRT-IN-6		SIRT1, IC₅₀: >50 μM	SIRT2, IC₅₀: >50 μM	SIRT3, IC₅₀: >50 μM
A1B11			SIRT2, IC₅₀: 5.3 μM

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Sirtuin

Sirtuin

Sirtuin Isoform Specific Products:

Sirtuin Isoform Specific Products:

Sirtuin Related Products (211)

Antibodies (9)

Sirtuin Isoform Comparison

Sirtuin Related Products (211):