2. Signaling Pathways
  3. PROTAC
  4. LYTACs

LYTACs

Lysosome-targeting chimeras

LYTACs

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Lysosome targeting chimera (LYTAC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. LYTAC degrades target proteins by binding to asialoglycoprotein receptor on lysosomal through its asialoglycoprotein receptor ligand. Another side of LYTAC is usually an antibody so it can bind to target protein for degradation.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-148476
    Tri-GalNAc-DBCO 99.92%
    Tri-GalNAc-DBCO can bind to the desialic acid glycoprotein receptor (ASGPR) to drive protein downregulation and target protein degradation, where GalNAc is a high-affinity ligand for hepatocyte-specific ASGPR. Tri-GalNAc-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Tri-GalNAc-DBCO
  • HY-147102
    tri-GalNAc biotin 99.40%
    tri-GalNAc biotin is a small molecule lysosome targeting degrader. tri-GalNAc is a ligand of ASGPR (asialoglycoprotein receptor). tri-GalNAc biotin can facilitate the uptake of NeutrAvidin (NA) through ASGPR in liver cells. tri-GalNAc biotin delivers NeutrAvidin to lysosome for degradation. tri-GalNAc biotin can be used for research of LYsosome TArgeting Chimera (LYTAC).
    tri-GalNAc biotin
  • HY-139482
    tri-GalNAc-COOH 1953146-81-0 ≥99.0%
    tri-GalNAc-COOH is an asialoglycoprotein receptor (ASGPR) ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research.
    tri-GalNAc-COOH
  • HY-145368B
    Tri-GalNAc(OAc)3-Perfluorophenyl
    Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl modified Tri-GalNAc(OAc)3 (HY-148118), a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation. tri-GalNAc: triantenerrary N-acetylgalactosamine; LYTAC: lysosome-targeting chimera.
    Tri-GalNAc(OAc)3-Perfluorophenyl
  • HY-147354
    TriGalNAc CBz 186613-57-0 99.02%
    TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies.
    TriGalNAc CBz
  • HY-148118A
    Tri-GalNAc(OAc)3 TFA 1159408-65-7 ≥98.0%
    Tri-GalNAc(OAc)3 TFA is a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation. tri-GalNAc: triantenerrary N-acetylgalactosamine; LYTAC: lysosome-targeting chimera.
    Tri-GalNAc(OAc)3 TFA
  • HY-148118
    Tri-GalNAc(OAc)3 1159408-64-6 98.09%
    Tri-GalNAc(OAc)3 is a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation. tri-GalNAc: triantenerrary N-acetylgalactosamine; LYTAC: lysosome-targeting chimera.
    Tri-GalNAc(OAc)3
  • HY-145368
    Tri-GalNAc-NHS ester 1953146-83-2
    Tri-GalNAc-NHS ester is a LYsosome TArgeting Chimera (LYTAC) and a ligand of asialoglycoprotein receptor (ASGPR). ASGPR is a lysosomal targeting receptor specifically expressed on liver cells, for the degradation of extracellular proteins including membrane proteins. Tri-GalNAc-NHS ester can be used as a protein degrader and it can be used for the research of LYTAC.
    Tri-GalNAc-NHS ester
  • HY-142885
    M-MoDE-A (2) 2378837-56-8
    M-MoDE-A (2) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR).
    M-MoDE-A (2)
  • HY-142881
    D-MoDE-A (1) 2378837-67-1
    D-MoDE-A (1) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR).
    D-MoDE-A (1)
  • HY-145013
    tri-GalNAc-COOH (acetylation) 3008204-26-7
    tri-GalNAc-COOH acetylation is the acetylated and modified form of tri-GalNAc-COOH. tri-GalNAc-COOH acetylation can be used for the synthesis of LYTAC.
    tri-GalNAc-COOH (acetylation)
Cat. No. Product Name / Synonyms Application Reactivity