2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. ADAMTS

ADAMTS

Adamalysin-like metalloproteinase with thrombospondin motifs

ADAMTS is a class of zinc-dependent secreted metalloproteases that primarily participate in extracellular matrix (ECM) degradation and remodeling, blood coagulation regulation, and cardiovascular homeostasis. This family consists of 19 ADAMTS proteases and 7 ADAMTS-like proteins, each with distinct biological functions. Among them, ADAMTS1, 4, and 5 are responsible for proteoglycan degradation, ADAMTS2, 3, and 14 facilitate procollagen processing, ADAMTS13 regulates coagulation by cleaving von Willebrand factor (vWF), and ADAMTS7 and 12 influence vascular smooth muscle cell migration, contributing to atherosclerosis. Additionally, ADAMTS1 and ADAMTS8 function as tumor suppressors, inhibiting angiogenesis and thereby restricting tumor growth. Dysregulation of ADAMTS functions is associated with various diseases. For example, mutations in ADAMTS2 lead to Ehlers-Danlos syndrome (a connective tissue disorder with skin hyperelasticity) due to impaired collagen maturation; excessive ADAMTS5 activity disrupts proteoglycan homeostasis and exacerbates osteoarthritis; ADAMTS13 deficiency causes thrombotic thrombocytopenic purpura (TTP), resulting in abnormal blood clot formation. Additionally, ADAMTS7 promotes vascular remodeling, accelerating atherosclerosis progression. Therefore, selective inhibitors or activators targeting ADAMTS have emerged as potential therapeutic strategies for joint diseases, thrombotic disorders, and cardiovascular conditions[1].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137430
    Aldumastat
    		Inhibitor 99.54%
    Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research.
    Aldumastat
  • HY-145061
    ADAMTS-5-IN-3
    		Inhibitor 98.90%
    ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis.
    ADAMTS-5-IN-3
  • HY-114996
    ADAMTS-5 Inhibitor
    		Inhibitor 99.30%
    ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).
    ADAMTS-5 Inhibitor
  • HY-162284
    BAY-9835
    		Antagonist 99.46%
    BAY-9835 is a potent and orally active ADAMTS7 and ADAMTS12 antagonist with IC50s of 6 nM and 30 nM, respectively. BAY-9835 is very selective against a range of off-targets and metalloproteases. BAY-9835 can be used for the atherogenesis research.
    BAY-9835
  • HY-P10398
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA is a substrate for ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5 activity.
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA
  • HY-168003
    ADAMTS7-IN-1
    		Inhibitor 98.91%
    ADAMTS7-IN-1 (Compound 3a) is an effective and selective inhibitor of ADAMTS7 with a Ki value of 9 nM. ADAMTS7-IN-1 can be used in the research of atherosclerosis.
    ADAMTS7-IN-1
  • HY-172394
    ZSNI-21
    		Inhibitor
    ZSNI-21 is a dual inhibitor of ADAM17 and HDAC2. ZSNI-21 effectively inhibits the proliferation of Bel-7402 cells and demonstrates significant anti-metastatic capabilities against HCC-LM3 cells. ZSNI-21 is promising for research of hepatocellular carcinoma (HCC).
    ZSNI-21
  • HY-135710
    ADAMTS-5-IN-2
    		Inhibitor 98.73%
    ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis.
    ADAMTS-5-IN-2
  • HY-P99671
    Isecarosmab
    		Inhibitor
    Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life.
    Isecarosmab
  • HY-P4003
    Adamtsostatin 16
    		Inhibitor
    Adamtsostatin 16 is an anti-angiogenic 17-amino acid peptide containing type I thrombospondin motifs.
    Adamtsostatin 16
  • HY-P10468
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5 activity.
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2
  • HY-P4002
    Adamtsostatin 18
    		Inhibitor
    Adamtsostatin 18 is an anti-angiogenic peptide derived from proteins containing type I thrombospondin motifs. Adamtsostatin 18 inhibits cell migration and proliferation.
    Adamtsostatin 18
  • HY-P4001
    Adamtsostatin 4
    		Inhibitor
    Adamtsostatin 4 is an anti-angiogenic peptide. Adamtsostatin 4 can be used for the research of anti-angiogenic.
    Adamtsostatin 4
  • HY-160822
    AGG-523
    		Inhibitor
    AGG-523 (PF-5212371) is a reversible, non-hydroxamate, zinc-binding selective aggrecanase 1 (ADAMTS4) and aggrecanase 2 (ADAMTS5) inhibitor. AGG-523 can be used for the study of osteoarthritis (OA).
    AGG-523
Cat. No. Product Name / Synonyms Application Reactivity