2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Butyrophilins

Butyrophilins

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Butyrophilins (BTN family), similarly as the B7 family of regulatory proteins, belongs to the immunoglobulin (Ig) superfamily. Butyrophilins are glycoproteins contain two extracellular immunoglobulin domains, stabilized with disulfide bonds: constant IgC, and variable IgV and a transmembrane region. Butyrophilins are present on lymphocytes, dendritic cells, monocytes, macrophages, neutrophils and eosinophils, and acts as immune system regulators (stimulatory or inhibitory effect). In humans, BTN family includes 7 butyrophilin proteins (BTN1A1, BTN2A1, BTN2A2, BTN2A3, BTN3A1, BTN3A2, BTN3A3), 5 butyrophilin-like proteins (BTNL) (BTNL2, BTNL3, BTNL8, BTNL9, BTNL10) and the SKINT-like factor (SKINTL-selection and upkeep of intraepithelial T-cells), while in mice, 11 proteins of this family have been described: BTN1A1, BTN2A2, BTNL1, BTNL2, BTLN4, BTNL5, BTNL6, BTNL7, BTNL9, BTNL10 and SKINTL, which differ in humans and mice. Butyrophilins have been also demonstrated to play a role in various infections, e.g. tuberculosis or diseases that include sarcoidosis, systemic lupus erythematosus, rheumatoid arthritis, genetic metabolic diseases, ulcerative colitis, cancer and kidney disease. Noteworthy, some BTN/BTNLs are co-inhibitory whereas others are co-stimulatory in the regard of conventional T cell function regulation. For instance, human BTN3A1 (CD277), mouse BTNL2 and murine BTNL1 are considered as co-inhibitory molecules; BTNL8 and BTN3A2 are recognized as co-stimulatory molecules.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70060
    BTN1A1 Protein, Human (HEK293, Fc)

    rHuButyrophilin subfamily 1 member A1/BTN1A1, Fc; Butyrophilin Subfamily 1 Member A1; BT; BTN1A1; BTN

    		Human HEK293
    BTN1A1 Protein is implicated in milk-fat droplet secretion and may serve as a membrane-associated receptor in lactation processes. Additionally, it exhibits immune-regulatory functions, inhibiting T-cell proliferation and modulating cytokine secretion. BTN1A1's association with xanthine dehydrogenase/oxidase suggests diverse cellular functions, inviting further exploration into its role in various biological pathways. BTN1A1 Protein, Human (HEK293, Fc) is the recombinant human-derived BTN1A1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of BTN1A1 Protein, Human (HEK293, Fc) is 216 a.a., with molecular weight of 60-80 kDa.
  • HY-P72762
    BTNL6 Protein, Mouse (HEK293, His)

    BTNL6; Gm6519; NG13; Butyrophilin-like 6; EG624681

    		Mouse HEK293
    BTNL6 Protein, part of the immunoglobulin superfamily in the BTN/MOG family, is associated with immune responses and cellular recognition. Its membership suggests involvement in diverse immunological processes, potentially contributing to intricate immune regulation. Further exploration is needed to understand BTNL6's specific functions within the broader immunoglobulin superfamily context and its role in modulating immune responses. BTNL6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived BTNL6 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of BTNL6 Protein, Mouse (HEK293, His) is 221 a.a., with molecular weight of ~30 kDa.
  • HY-P76179
    BTN3A1/CD277 Protein, Human (HEK293)

    Butyrophilin subfamily 3 member A1; CD277; BTN3A1; BTF5

    		Human HEK293
    BTN3A1/CD277 Protein, functioning as a homodimer, regulates activated T-cell proliferation, controls cytokine release, and mediates T-cell response to cells with elevated phosphorylated metabolites, such as isopentenyl pyrophosphate, contributing to T-cell activation and the adaptive immune response. BTN3A1/CD277 Protein, Human (HEK293) is the recombinant human-derived BTN3A1/CD277 protein, expressed by HEK293 , with tag free.
  • HY-P7681
    BTN2A1 Protein, Human (HEK293, His)

    rHuBTN2A1, His; Butyrophilin subfamily 2 member A1; BTN2A1

    		Human HEK293
    BTN2A1 Protein, Human (HEK293, His) is a recombinant mouse BTN2A1 produced in HEK293 cells, with His tag. BTN2A1 is a member of butyrophilin family.
  • HY-P7682
    BTN2A2 Protein, Human (HEK293, Fc)

    rHuBTN2A2, C-Fc; Butyrophilin subfamily 2 member A2; BTN2A2

    		Human HEK293
    BTN2A2 Protein, Human (HEK293, Fc) is a recombinant human BTN2A2 produced in HEK293 cells, with Fc tag. BTN2A2 is a member of butyrophilin family.
  • HY-P7686
    BTNL2 Protein, Mouse (HEK293, His)

    rMuBTNL2, His; Butyrophilin-like protein 2; BTNL2

    		Mouse HEK293
    BTNL2 Protein, Mouse (HEK293, His) is a recombinant mouse BTNL2 produced in HEK293 cells, with His tag. BTNL2 is a member of butyrophilin-like proteins.
  • HY-P7687
    BTNL9 Protein, Human (HEK293, His)

    rHuBTNL9, His; Butyrophilin-like protein 9; BTNL9

    		Human HEK293
    BTNL9 Protein, Human (HEK293, His) is a recombinant human BTNL9 produced in HEK293 cells, with His tag. BTNL9 is a member of BTNL family.
  • HY-P700958
    BTN2A2 Protein, Mouse (HEK293, His)

    BTN2A2; BT2.2; BTF2; BTN2.2

    		Mouse HEK293
    BTN2A2 protein inhibits CD4 and CD8 T-cell proliferation activated by anti-CD3 antibodies. It regulates T-cell metabolism, suppressing IL2 and IFNG cytokine secretion. BTN2A2 plays a pivotal role in immune response modulation, maintaining immune homeostasis by limiting T-cell activation and effector functions. BTN2A2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived BTN2A2 protein, expressed by HEK293 , with C-His labeled tag. The total length of BTN2A2 Protein, Mouse (HEK293, His) is 215 a.a., with molecular weight of 40-50 kDa.
  • HY-P79382
    BTNL8 Protein, Human (HEK293, hFc)

    Butyrophilin-like protein 8; BTNL8; Butyrophilin-like 8

    		Human HEK293
    BTNL8 protein potentially stimulates the primary immune response by affecting sub-optimally stimulated T-cells through the TCR/CD3 complex. It promotes T-cell proliferation and enhances cytokine production. BTNL8 Protein, Human (HEK293, hFc) is the recombinant human-derived BTNL8 protein, expressed by HEK293, with C-hFc labeled tag. The total length of BTNL8 Protein, Human (HEK293, hFc) is 221 a.a., with molecular weight of approximately 65 kDa.
  • HY-P78080
    BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, His-Avi)

    CD277; BTN3A1; BTF5; BT3.1; BTN3.1

    		Human HEK293
    BTN3A1/CD277 Protein, functioning as a homodimer, regulates activated T-cell proliferation, controls cytokine release, and mediates T-cell response to cells with elevated phosphorylated metabolites, such as isopentenyl pyrophosphate, contributing to T-cell activation and the adaptive immune response. BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived BTN3A1/CD277 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
  • HY-P72343
    BTN1A1 Protein, Human (Biotinylated, HEK293, His-Avi)

    Butyrophilin Subfamily 1 Member A1; BT; BTN

    		Human HEK293
    BTN1A1 Protein is implicated in milk-fat droplet secretion and may serve as a membrane-associated receptor in lactation processes. Additionally, it exhibits immune-regulatory functions, inhibiting T-cell proliferation and modulating cytokine secretion. BTN1A1's association with xanthine dehydrogenase/oxidase suggests diverse cellular functions, inviting further exploration into its role in various biological pathways. BTN1A1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived BTN1A1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of BTN1A1 Protein, Human (Biotinylated, HEK293, His-Avi) is 216 a.a., with molecular weight of 35-40 kDa.
  • HY-P72345
    BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, Fc-Avi)

    Butyrophilin subfamily 3 member A1; CD277; BTN3A1; BTF5

    		Human HEK293
    BTN3A1/CD277 Protein, functioning as a homodimer, regulates activated T-cell proliferation, controls cytokine release, and mediates T-cell response to cells with elevated phosphorylated metabolites, such as isopentenyl pyrophosphate, contributing to T-cell activation and the adaptive immune response. BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived BTN3A1/CD277 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.
  • HY-P72346
    BTN3A2 Protein, Human (Biotinylated, HEK293, His-Avi)

    Butyrophilin subfamily 3 member A2; BT3.2; BTF3; BTF4

    		Human HEK293
    BTN3A2 protein, functioning as a homodimer, regulates T-cell responses in the adaptive immune system by inhibiting the release of IFNG from activated T-cells. BTN3A2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived BTN3A2 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.
  • HY-P72763
    BTN3A1/CD277 Protein, Human (HEK293, His)

    Butyrophilin subfamily 3 member A1; CD277; BTN3A1; BTF5

    		Human HEK293
    BTN3A1/CD277 Protein, functioning as a homodimer, regulates activated T-cell proliferation, controls cytokine release, and mediates T-cell response to cells with elevated phosphorylated metabolites, such as isopentenyl pyrophosphate, contributing to T-cell activation and the adaptive immune response. BTN3A1/CD277 Protein, Human (HEK293, His) is the recombinant human-derived BTN3A1/CD277 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P7680
    BTN1A1 Protein, Mouse (HEK293, His)

    rMuBTN1A1, His; Butyrophilin subfamily 1 member A1; BTN1A1;

    		Mouse HEK293
    BTN1A1 Protein, Mouse (HEK293, His) is a recombinant mouse BTN1A1 produced in HEK293 cells, with His tag. BTN1A1 is a member of butyrophilin family.
  • HY-P7683
    BTN3A1/CD277 Protein, Human (HEK293, Fc)

    rHuBTN3A1/CD277, C-Fc; Butyrophilin subfamily 3 member A1; CD277; BTN3A1

    		Human HEK293
    BTN3A1/CD277 Protein, functioning as a homodimer, regulates activated T-cell proliferation, controls cytokine release, and mediates T-cell response to cells with elevated phosphorylated metabolites, such as isopentenyl pyrophosphate, contributing to T-cell activation and the adaptive immune response. BTN3A1/CD277 Protein, Human (HEK293, Fc) is a recombinant human BTN3A1 produced in HEK293 cells, with His tag. BTN3A1 is a member of butyrophilin family.
  • HY-P7684
    BTN3A2 Protein, Human (HEK293, His)

    rHuBTN3A2, His; Butyrophilin subfamily 3 member A2; BTN3A2

    		Human HEK293
    BTN3A2 Protein, Human (HEK293, His) is a recombinant human BTN3A2 produced in HEK293 cells, with His tag. BTN3A2 is a member of butyrophilin family.
  • HY-P7685
    BTN3A3 Protein, Human (HEK293, His)

    rHuBTN3A3, His; Butyrophilin subfamily 3 member A3; BTN3A3

    		Human HEK293
    BTN3A3 Protein, Human (HEK293, His) is a recombinant human BTN3A3 produced in HEK293 cells, with His tag. BTN3A3 is a member of butyrophilin family.
  • HY-P7689
    BTN1A1 Protein, Human (HEK293, His)

    rHuBTN, His; Butyrophilin Subfamily 1 Member A1; BTN

    		Human HEK293
    BTN1A1 Protein, Human (HEK293, His) is a recombinant human BTN1A1 produced in HEK293 cells, with His tag. BTN1A1 is a member of butyrophilin family.
  • HY-P77581
    BTN3A1/CD277 Protein, Cynomolgus (HEK293, His-Avi)

    CD277; BTN3A1; BTF5; BT3.1; BTN3.1

    		Cynomolgus HEK293
    BTN3A1/CD277 protein belongs to the BTN/MOG family of the immunoglobulin superfamily and may be involved in immune response and cell recognition. Its membership suggests involvement in immune processes, suggesting complex interactions underlying immune regulation. BTN3A1/CD277 Protein, Cynomolgus (HEK293, His-Avi) is the recombinant cynomolgus-derived BTN3A1/CD277 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of BTN3A1/CD277 Protein, Cynomolgus (HEK293, His-Avi) is 219 a.a., with molecular weight of 30-35 kDa.
Cat. No. Product Name Effect Purity