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  4. Cathepsin

Cathepsin

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Cathepsins are protease that can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). All the cathepsins share the same structural scaffold, also called the papain-like fold, which consists of two subdomains, referred to as the L- and R-domains. The active site cleft is at the top of the molecule between the L- and R-domains and contains the conserved catalytic dyad Cys-His. Cathepsins are vital for digestion, coagulation, immune response, adipogenesis, hormone liberation, peptide synthesis, among a litany of other functions.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7755
    Cathepsin L2 Protein, Human (HEK293, His)

    rHuCathepsin L2, His; Cathepsin L2; Cathepsin U; Cathepsin V; CTSL2; CATL2; CTSU; CTSV

    		Human HEK293
    Cathepsin L2 Protein, Human (HEK293, His) is a functional cysteine proteinase, mainly expressed in the cornea, testis, thymus, and epidermis.
  • HY-P7750
    Cathepsin E Protein, Human (HEK293, His)

    rHuCathepsin E, His; Cathepsin E; CTSE

    		Human HEK293
    Cathepsin E Protein, Human (HEK293, His) is a human cathepsin E with a His tag. Cathepsin E is an aspartic protease and a member of the peptidase A1 family of proteases..
  • HY-P7755A
    Cathepsin L2 Protein, Human (HEK293, His, solution)

    Cathepsin L2; Cathepsin U; Cathepsin V; CTSL2; CATL2; CTSU; CTSV

    		Human HEK293
    Cathepsin L2 is a cysteine protease thought to play a crucial role in corneal physiology, but its specific function and mechanism are still under investigation. The unique properties of cathepsin L2 suggest that it may be involved in important cellular and molecular events within the cornea, underscoring its importance in maintaining ocular tissue health. Cathepsin L2 Protein, Human (HEK293, His, solution) is the recombinant human-derived Cathepsin L2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cathepsin L2 Protein, Human (HEK293, His, solution) is 317 a.a., with molecular weight of ~33-38 kDa.
  • HY-P75448
    Cathepsin Z/CTSZ Protein, Mouse (HEK293, His)

    Cathepsin P; Cathepsin X/Z/P; Cathepsin Z; CTSX; CTSZ

    		Mouse HEK293
    The cathepsin Z/CTSZ protein displays multiple carboxyl monopeptidase and carboxyl dipeptidase activities, emphasizing its enzymatic versatility. It is capable of expertly producing kinin-enhancing peptides, which play a vital role in regulating biological processes. Cathepsin Z/CTSZ Protein, Mouse (HEK293, His) is the recombinant mouse-derived Cathepsin Z/CTSZ protein, expressed by HEK293 , with C-His labeled tag. The total length of Cathepsin Z/CTSZ Protein, Mouse (HEK293, His) is 284 a.a., with molecular weight of ~38 kDa.
  • HY-P7745
    Cathepsin A Protein, Human (HEK293, His, solution)

    rHuCathepsin A, His; Lysosomal protective protein; CTSA; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A

    		Human HEK293
    Cathepsin A Protein, Human (HEK293, His, solution) is a 58-60 kDa human cathepsin A protein with a His-flag. Cathepsin A is a multicatalytic enzyme with carboxypeptidase activities.
  • HY-P7745A
    Cathepsin A Protein, Human (HEK293, His)

    Lysosomal protective protein; CTSA; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A

    		Human HEK293
    Cathepsin A protein is an important protective factor for β-galactosidase and neuraminidase, maintaining their stability and optimizing enzyme activity. Its carboxypeptidase activity expands its functional repertoire and can deamid tachykinins and participate in a variety of biochemical processes. Cathepsin A Protein, Human (HEK293, His) is the recombinant human-derived Cathepsin A, expressed by HEK293 , with C-6*His labeled tag. The total length of Cathepsin A Protein, Human (HEK293, His) is 452 a.a.,
  • HY-P7754
    Cathepsin L1 Protein, Human (HEK293, His, solution)

    rHuCathepsin L1, His; Cathepsin L1; Major Excreted Protein; MEP; CTSL1; CTSL

    		Human HEK293
    Cathepsin L1 Protein, Human (HEK293, His, solution) is a major cysteine protease that plays a major role in intracellular protein catabolism.
  • HY-P7748
    Cathepsin D Protein, Human (HEK293, His, solution)

    rHuCathepsin D, His; Cathepsin D; CTSD; CPSD

    		Human HEK293
    Cathepsin D Protein, Human (HEK293, His, solution) is an approximately 50.0 kDa cathepsin D protein with a His-flag. Cathepsin D is a representative lysosomal aspartic proteinases and belongs to the peptidase C1 family.
  • HY-P7749
    Cathepsin D Protein, Mouse (HEK293, His)

    rMuCathepsin D, His; Cathepsin D; CTSD; CPSD

    		Mouse HEK293
    Cathepsin D Protein, Mouse (HEK293, His) is an approximately 56.0 kDa mouse cathepsin D with a His tag. Cathepsin D is a lysosomal aspartic protease of the pepsin family.
  • HY-P7753
    Cathepsin L1 Protein, Mouse (HEK293, His)

    rMuCathepsin L, His; Cathepsin L1; Major excreted protein; p39 cysteine proteinase; CTSL1

    		Mouse HEK293
    Cathepsin L Protein, Mouse (HEK293, His) is a lysosomal acid cysteine protease, which is associated with tumor occurrence, development, and metastasis.
  • HY-P7757
    Cathepsin S Protein, Mouse (HEK293, His)

    rMuCathepsin S, His; Cathepsin S; CTSS

    		Mouse HEK293
    Cathepsin S Protein, Mouse (HEK293, His) is potent cysteine protease which can promote degradation of damaged or unwanted proteins in the endo-lysosomal pathway.
  • HY-P70830
    Cathepsin B Protein, Human (His)

    Cathepsin B; APP Secretase; APPS; Cathepsin B1; CTSB; CPSB

    		Human E. coli
    Cathepsin B Protein, a thiol protease, is crucial for intracellular protein degradation, cleaving matrix extracellular phosphoglycoprotein MEPE. It's implicated in solubilizing cross-linked TG/thyroglobulin in the thyroid follicle lumen. Associated with tumor invasion and metastasis, Cathepsin B signifies potential relevance in cancer-related pathways. Cathepsin B Protein, Human (His) is the recombinant human-derived Cathepsin B protein, expressed by E. coli , with C-6*His labeled tag. The total length of Cathepsin B Protein, Human (His) is 322 a.a., with molecular weight of 34 & 38-50 kDa, respectively.
  • HY-P7747
    Cathepsin B Protein, Mouse (HEK293, His)

    rMuCathepsin B, His; Cathepsin B; Ctsb; Cathepsin B1

    		Mouse HEK293
    Cathepsin B Protein, Mouse (HEK293, His) is an approximately 32-50 kDa Cathepsin B protein with a His-flag. Cathepsin B is an enzymatic protein belonging to the peptidase C1 family.
  • HY-P7756
    Cathepsin S Protein, Human (HEK293, His)

    rHuCathepsin S, His; Cathepsin S; CTSS

    		Human HEK293
    Cathepsin S Protein, Human (HEK293, His) is potent cysteine protease which can promote degradation of damaged or unwanted proteins in the endo-lysosomal pathway.
  • HY-P7758
    Cathepsin Z/CTSZ Protein, Human (HEK293, His, solution)

    rHuCathepsin X, His; Cathepsin Z; Cathepsin P; Cathepsin X; CTSZ

    		Human HEK293
    Cathepsin Z/CTSZ Protein, Human (HEK293, His, solution) is a lysosomal cysteine protease, found predominantly in cells of monocyte/macrophage lineage.
  • HY-P78682
    Cathepsin B Protein, Human (L26V, HEK293, His)

    CTSB; CPSB; APPS

    		Human HEK293
    Cathepsin B Protein, a thiol protease, is crucial for intracellular protein degradation, cleaving matrix extracellular phosphoglycoprotein MEPE. It's implicated in solubilizing cross-linked TG/thyroglobulin in the thyroid follicle lumen. Associated with tumor invasion and metastasis, Cathepsin B signifies potential relevance in cancer-related pathways. Cathepsin B Protein, Human (L26V, HEK293, His) is the recombinant human-derived Cathepsin B protein, expressed by HEK293 , with C-His labeled tag and L26V, , , , mutation. The total length of Cathepsin B Protein, Human (L26V, HEK293, His) is 322 a.a., with molecular weight of 10-45 kDa.
  • HY-P7748A
    Cathepsin D Protein, Human (HEK293, C-His)

    rHuCathepsin D, His; Cathepsin D; CTSD; CPSD

    		Human HEK293
    Cathepsin D protein is an acidic protease that actively participates in intracellular protein breakdown. Studies have shown that it is critical in the processing of amyloid precursor protein (APP), with ADAM30-mediated cleavage and activation leading to APP degradation. Cathepsin D Protein, Human (HEK293, C-His) is the recombinant human-derived Cathepsin D protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cathepsin D Protein, Human (HEK293, C-His) is 392 a.a., with molecular weight of ~44.78 kDa.
  • HY-P7754A
    Cathepsin L1 Protein, Human (HEK293, C-His)

    rHuCathepsin L1, His; Cathepsin L1; Major Excreted Protein; MEP; CTSL1; CTSL

    		Human HEK293
    Cathepsin L1 protein is a thiol protease that plays a key role in lysosomal protein degradation, affecting cellular functions such as turnover, antigen processing, and bone remodeling. It dissolves cross-linked TG/thyroglobulin, releasing the thyroid hormone thyroxine (T4) in the thyroid follicular cavity. Cathepsin L1 Protein, Human (HEK293, C-His) is the recombinant human-derived Cathepsin L1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cathepsin L1 Protein, Human (HEK293, C-His) is 316 a.a., with molecular weight of ~32.8 kDa.
  • HY-P7758A
    Cathepsin Z/CTSZ Protein, Human (HEK293, C-His)

    rHuCathepsin X, His; Cathepsin Z; Cathepsin P; Cathepsin X; CTSZ

    		Human HEK293
    Cathepsin Z/CTSZ Protein exhibits dual carboxy-monopeptidase and carboxy-dipeptidase activities, as evidenced by research. Additionally, it displays functional versatility by generating kinin potentiating peptides. Cathepsin Z/CTSZ Protein, Human (HEK293, C-His) is the recombinant human-derived Cathepsin Z/CTSZ protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cathepsin Z/CTSZ Protein, Human (HEK293, C-His) is 280 a.a., with molecular weight of 37-40 kDa.
  • HY-P7993A
    Cathepsin B Protein, Human (HEK293, C-His)

    APPS, Cathepsin B1

    		Human HEK293
    Cathepsin B Protein, Human (HEK293, His) functions in intracellular protein catabolism and in certain situations may also be involved in other physiological processes, such as processing of antigens in the immune response, hormone activation and bone turnover.
Cat. No. Product Name Effect Purity