2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Oct3/4

Oct3/4

POU5F1; Slc22a3

Oct3/4

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Oct3/4 (also known as POU5F1 and Oct4) is regarded as one of the key regulators of pluripotency. Oct-4 is a homeodomain transcription factor of the POU family. This protein is critically involved in the self-renewal of undifferentiated embryonic stem cells. it is frequently used as a marker for undifferentiated cells. Oct-4 expression must be closely regulated; too much or too little will cause differentiation of the cells.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12303
    OAC1
    		Activator 99.56%
    OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time.
    OAC1
  • HY-18772
    O4I2
    		Activator 99.30%
    O4I2 is a potent Oct3/4 inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1.
    O4I2
  • HY-12884
    OAC2
    		Activator 98.10%
    OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.
    OAC2
  • HY-B0380A
    Trimebutine maleate
    		99.91%
    Trimebutine maleate is an orally anti-tumor agent. Trimebutine maleate selectively suppresses stemness and proliferation of ovarian cancer stem cells (CSCs). Trimebutine maleate reduces the colonic muscle hypercontractility, modulates gastrointestinal motility, induces apoptosis and can be used for the research of glioma/glioblastoma and irritable bowel syndrome.
    Trimebutine maleate
  • HY-18771
    O4I1
    		Activator 98.05%
    O4I1 is as a potent Oct3/4 inducer.
    O4I1
  • HY-119666
    Rooperol
    Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as Oct4, Nanog, and Sox2, ultimately exerting its anticancer effects.
    Rooperol
  • HY-119672
    Oct4 inducer-1
    		Activator 98.27%
    Oct4 inducer-1 (compound OAC-3) is a potent Oct4 activator. Oct4 inducer-1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. Oct4 inducer-1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time.
    Oct4 inducer-1
  • HY-18773
    Oct3/4-inducer-1
    		Activator 98.12%
    Oct3/4-inducer-1 (compound 2) is a potent Oct3/4 inducer. Oct3/4-inducer-1 promotes expression and stabilization of Oct3/4, and enhances its transcriptional activity in diverse human somatic cells.
    Oct3/4-inducer-1
  • HY-B0380AR
    Trimebutine maleate (Standard)
    Trimebutine (maleate) (Standard) is the analytical standard of Trimebutine (maleate). This product is intended for research and analytical applications. Trimebutine maleate is an orally anti-tumor agent. Trimebutine maleate selectively suppresses stemness and proliferation of ovarian cancer stem cells (CSCs). Trimebutine maleate reduces the colonic muscle hypercontractility, modulates gastrointestinal motility, induces apoptosis and can be used for the research of glioma/glioblastoma and irritable bowel syndrome.
    Trimebutine maleate (Standard)
  • HY-154951
    Oct4 inducer-2
    		Inducer
    Oct4 inducer-2 is an OCT4 inducer, which can maintain the formation of hiPSCs by promoting the expression of endogenous OCT4, which can be used in anti-aging research.
    Oct4 inducer-2
Cat. No. Product Name / Synonyms Application Reactivity