2. Recombinant Proteins
  3. Receptor Proteins

Receptor Proteins

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Receptors are proteins molecules located on the cell surface or within the cytoplasm that function by specifically recognizing and binding to a ligand molecule. The ligands are the signaling molecules released by one cell to signal either itself or a different cell. The major types of cellular signaling include autocrine, signal across a gap junction, paracrine, and endocrine. These types of signaling require ligand and receptor. Cellular receptors are diverse and broadly categorized into internal receptors, cell-surface receptors, ion channel receptors, G-protein-coupled receptors (GPCRs), and enzyme-linked receptors.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P75294
    Delta-like protein 4/DLL4 Protein, Human (HEK293, Fc)

    Delta-like protein 4; Delta4; DLL4

    		Human HEK293
    The DLL4 protein, a homolog of the Drosophila delta gene family, encodes Notch ligands with a DSL domain, EGF repeats, and a transmembrane domain. DLL4 is widely expressed in tissues, including placenta (RPKM 11.5), fat (RPKM 11.2), and 22 others. Delta-like protein 4/DLL4 Protein, Human (HEK293, Fc) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Human (HEK293, Fc) is 498 a.a., with molecular weight of 100-110 kDa.
  • HY-P71963
    IL-17RA Protein, Human (HEK293, hFc)

    CANDF5; CD217; CD217 antigen; CDw217; CTLA8; HIL 17R; hIL17R; I17RA_HUMAN; IL 17 receptor A; IL 17 receptor; IL 17RA; IL-17 receptor A; IL-17RA; IL17; IL17A receptor; IL17R; IL17RA; IMD51; Interleukin 17 receptor A; Interleukin-17 receptor A; MGC10262

    		Human HEK293
    IL-17RA (Interleukin 17 receptor A), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed ubiquitously and exhibits a broad tissue distribution, and plays a role in many inflammatory and autoimmune diseases. IL-17RA is a common co-receptor subunit for other members of the IL-17 family. IL-17RA associates with IL-17RC to form a signaling receptor complex for IL-17A and IL-17F. IL-17RA Protein, Human (HEK 293, hFc) is produced in HEK293 cells with a C-Terminal hFc-tag.
  • HY-P70111
    Delta-like protein 4/DLL4 Protein, Human (HEK293, His)

    rHuDelta-like protein 4/DLL4, His; Delta-like protein 4; Drosophila Delta homolog 4; Delta4; DLL4

    		Human HEK293
    Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P70552
    VEGFR-2 Protein, Human (HEK293, His)

    Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; VEGFR2; VEGF R2

    		Human HEK293
    VEGFR-2 is a tyrosine-protein kinase of the cell surface receptors of VEGFA, VEGFC, and VEGFD that mediates activation of the MAPK1/ERK2, MAPK3/ERK1, and MAP kinase signaling pathways, as well as the AKT1 signaling pathway. VEGFR-2 can promote the proliferation, survival, migration and differentiation of endothelial cells. Overexpression of VEGFR-2 is associated with the development of tumors. VEGFR-2 Protein, Human (HEK293, His) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-2 Protein, Human (HEK293, His) is 745 a.a., with molecular weight of 84-140 kDa.
  • HY-P70807
    PVR/CD155 Protein, Human (HEK293, His)

    Poliovirus Receptor; Nectin-Like Protein 5; NECL-5; CD155; PVR; PVS

    		Human HEK293
    PVR/CD155 Protein, Human (HEK293, His) is a recombinant Human PVR expressed in HEK 293 cells with a His tag at the N-terminus. PVR, Human plays a role in cancer cell invasion and migration.
  • HY-P75292
    Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His)

    Delta-like protein 4; Delta4; DLL4

    		Mouse HEK293
    Delta-like 4/DLL4 protein is a key player in the Notch signaling pathway, acting as a ligand to activate NOTCH1 and NOTCH4. In angiogenesis, DLL4 regulates endothelial cell proliferation, migration, and angiogenic sprouting. Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) is 525 a.a., with molecular weight of ~68 kDa.
  • HY-P72024
    Growth Hormone R/GHR Protein, Human (HEK293, hFc)

    Somatotropin receptor Serum-binding protein;

    		Human HEK293
    Growth Hormone R (GHR) is the receptor for pituitary growth hormone, crucial in postnatal body growth regulation. Binding to its ligand activates the JAK2/STAT5 pathway, facilitating intracellular signaling. The soluble form, GHBP (Growth Hormone Binding Protein), acts as a growth hormone reservoir in the bloodstream. GHBP may modulate or inhibit growth hormone signaling, contributing to intricate growth process regulation. Growth Hormone R/GHR Protein, Human (HEK293, hFc) is the recombinant human-derived Growth Hormone R/GHR protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P70057
    TYRO3/DTK Protein, Mouse (388a.a, HEK293, His)

    rHuTyrosine-protein kinase receptor TYRO3/TYRO3, His; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF; TYRO3; BYK; DTK; RSE; SKY; TIF

    		Mouse HEK293
    TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as TULP1 or GAS6. TYRO3 is activated by ligand binding and regulates cell survival, migration, and differentiation, leading to dimerization and intracellular autophosphorylation to create docking sites for downstream signaling molecules. TYRO3/DTK Protein, Mouse (388a.a, HEK293, His) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TYRO3/DTK Protein, Mouse (388a.a, HEK293, His) is 388 a.a., with molecular weight of 55-70 kDa.
  • HY-P70635
    VEGFR-2 Protein, Human (745a.a, HEK293, Fc)

    Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; VEGFR2; VEGF R2

    		Human HEK293
    VEGFR-2 protein is a tyrosine protein kinase receptor for VEGFA, VEGFC and VEGFD and is critical in angiogenesis, blood vessel development and embryonic hematopoiesis. It promotes endothelial cell function and actin cytoskeletal reorganization. VEGFR-2 Protein, Human (745a.a, HEK293, Fc) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P70738
    Siglec-15 Protein, Human (HEK293, mFc)

    Sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3

    		Human HEK293
    The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (HEK293, mFc) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-mFc labeled tag.
  • HY-P70742
    Siglec-15 Protein, Human (HEK293, Fc)

    Sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3

    		Human HEK293
    The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P70767
    Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi)

    Sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3

    		Human HEK293
    The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.
  • HY-P70794
    TSLP R Protein, Human (HEK293, Fc)

    CRL2; CRL2cytokine receptor CRL2 precusor; CRLF2; CRLF2Y; CRLM-2; Cytokine receptor-like 2; cytokine receptor-like factor 2; ILXR; IL-XR; P2RY8/CRLF2 fusion; PCOR1; TSLP R; TSLP receptor; TSLPR

    		Human HEK293
    TSLP R Protein, a receptor for TSLP, forms a functional complex with IL7R, activating STAT3 and STAT5 for cell proliferation. It also activates JAK2, aiding in hematopoietic system development. TSLP R forms a heterodimer with CRLF2 and IL7R, highlighting its role in intricate signaling pathways crucial for cellular responses and hematopoietic development. TSLP R Protein, Human (HEK293, Fc) is the recombinant human-derived TSLP R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TSLP R Protein, Human (HEK293, Fc) is 207 a.a., with molecular weight of 60-80 kDa.
  • HY-P72019
    Siglec-2/CD22 Protein, Human (HEK293, His)

    B-cell receptor CD22; BL-CAM; Siglec-2; CD22; SIGLEC2

    		Human HEK293
    The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P7215
    IL-2R alpha/CD25 Protein, Human (HEK293, N-His)

    rHuIL-2Rα, His; TAC-antigen; CD25

    		Human HEK293
    IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions. IL-2R alpha/CD25 Protein, Human (HEK293, N-His) is a recombinant human IL-2R alpha protein with a His tag at the N-terminus and is expressed in HEK293 cells. It consists of 192 amino acids (E22-C213).
  • HY-P72267
    HGFR Protein, Human (HEK293, hFc)

    HGF receptor; SF receptor; Tyrosine-protein kinase Met

    		Human HEK293
    The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, hFc) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P72374
    HER2/CD340 Protein, Human (Biotinylated, HEK293, Fc-Avi)

    Proto-oncogene Neu; Tyrosine kinase-type cell surface receptor ERBB2; MLN19; NGL; TKR1

    		Human HEK293
    The HER2/CD340 protein is a dynamic tyrosine kinase that is essential in the neuregulin receptor complex and regulates microtubule dynamics. Upon activation, it triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B and promotes the association of APC and CLASP2 on the cell membrane to achieve microtubule stabilization. HER2/CD340 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived HER2/CD340 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.
  • HY-P72411
    Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi)

    MGC126774; PRO940; Siglec10; SLG2; sialic acid-binding Ig-like lectin 10; siglec-like gene 2

    		Human HEK293
    Siglec-10 Protein, identified as a putative adhesion molecule, mediates sialic-acid dependent cellular binding, preferring alpha-2,3- or alpha-2,6-linked sialic acid. Its sialic acid recognition site may undergo masking through cis interactions. In immune responses, Siglec-10 acts as an inhibitory receptor, inducing ligand-induced tyrosine phosphorylation, recruiting SH2 domain-containing phosphatases, and negatively regulating B-cell antigen receptor signaling via PTPN6/SHP-1. In collaboration with CD24, it selectively suppresses the immune response to DAMPs, regulates NK cell response, controls autoimmunity, and inhibits cross-presentation during adaptive immune responses by CD8-alpha(+) dendritic cells. Siglec-10 interacts with proteins including PTPN6/SHP-1, NCF1, CD24, HMGB1, RIGI, CBL, and PTPN11. Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived Siglec-10 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 530 a.a., with molecular weight of 100-130 kDa.
  • HY-P72812
    Activin RIA Protein, Human (HEK293, His-Fc)

    Activin receptor type-1; ACTR-I; ALK-2; SKR1; TSR-I; ACVR1; ACVRLK2

    		Human HEK293
    Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Activin RIA Protein, Human (HEK293, His-Fc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag . It consists of 124 amino acids (M1-V124).
  • HY-P72813
    ACVR2B Protein, Human (HEK293, Fc)

    Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B

    		Human HEK293
    ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 134amino acids (M1-T134).
Cat. No. Product Name Effect Purity