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Interferon & Receptors

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Interferons (IFNs) are a family of antiviral cytokines that are secreted by host cells in response to viral and microbial infections. The functions of IFNs are represented by three major biological activities: antiviral activity, antitumor activity and immunoregulatory activity. Based on their receptor specificity and sequence homology, the mammalian interferons are divided into three types based on amino acid sequence homology and the receptors they use: type I IFN (IFN-α, β, ε, κ, ω, δ, τ, ζ), type II IFN (IFN-γ), and type III IFN (IFN-λ1, λ2, λ3, λ4). IFN signaling is initiated by binding to distinct heterodimeric receptor complexes on the cell membrane.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7071
    IFN-gamma Protein, Mouse

    rMuIFN-γ; IFNG; IFN-gamma; Interferon gamma

    		Mouse E. coli
    IFN-gamma Protein is a cytokine belonging to the interferon family, secreted by activated immune cells such as T cells and NK cells. IFN-gamma Protein plays a key role in the immune system, exerting activities including regulating immune responses, antiviral effects, and antitumor effects. IFN-gamma Protein, Mouse is a recombinant IFN-gamma protein expressed by E. coli without any tag.
  • HY-P7023
    IFN-alpha 2b/IFNA2 Protein, Human

    rHuIFN-α2b; IFNA; INFA2; IFN-a 2b

    		Human E. coli
    IFN-alpha 2 (IFNA2), belongs to type I interferon family, is a protein secreted by cells infected by a virus and acting on other cells to inhibit viral infection. IFN-alpha 2 increases the frequencies of cytotoxic CD8+ T cells and induces CD4+ T cell depletion. IFN-alpha 2b/IFNA2 Protein, Human contains 165 a.a. (C24-E188), is a protein produced in E. coli with tag free.
  • HY-P7025
    IFN-gamma Protein, Human

    rHuIFN-γ; IFNG; IFN-gamma; Interferon gamma

    		Human E. coli
    IFN-gamma Protein, human activates STAT signaling pathway and affects gene regulation. IFN-gamma Protein, human activates effector immune cells and enhances antigen presentation. IFN-gamma Protein, human also regulates the hematopoietic stem cells development. IFN-gamma Protein, human is the recombinant human-derived IFN-gamma Protein, expressed by E. coli.
  • HY-P7025A
    IFN-gamma Protein, Human (CHO)

    rHuIFN-γ; IFNG; IFN-gamma; Interferon gamma

    		Human CHO
    IFN-gamma Protein, Human (CHO) is a cytokine with potent immunomodulatory, antiviral and antitumor activities.
  • HY-P7544
    IFN-alpha 2/IFNA2 Protein, Mouse

    Interferon alpha 2; IFNA2 Protein, Mouse

    		Mouse E. coli
    IFN-alpha 2/IFNA2 Protein, synthesized by macrophages, exhibits potent antiviral activities. Its interaction with IFNAR2 plays a pivotal role in signaling processes, contributing to the intricate network of antiviral defense mechanisms. IFN-alpha 2/IFNA2 Protein, Mouse is the recombinant mouse-derived IFN-alpha 2/IFNA2 protein, expressed by E. coli, with tag free.
  • HY-P7095
    IFN-gamma Protein, Rat

    rRtIFN-γ; IFNG; IFN-gamma; Interferon gamma

    		Rat E. coli
    IFN-gamma Protein, Rat is a pro-inflammatory cytokine with potent immunomodulatory, anti-proliferative, and antiviral properties.
  • HY-P73130
    IFN-beta Protein, Mouse (HEK293)

    Interferon beta; IFN-beta; IFNB1; IFB; IFNB

    		Mouse HEK293
    IFN-beta is a secretory cytokine produced by cells under viral infection or nucleic acid stimulation. IFNβ binds to cell surface heterodimeric receptors (IFNAR1/IFNAR2), activates the JAK-STAT signaling pathway, and induces the expression of interferon-stimulated genes (ISGs) (such as PKR, 2'5'-OAS). IFN-beta inhibits viral proliferation, regulates immune responses (such as inhibiting Th1 cell polarization, reducing pro-inflammatory cytokine secretion), inhibits the proliferation of vascular smooth muscle cells and tumor cells. IFN-beta has anti-atherosclerotic and vascular remodeling effects. Mouse (HEK293) is the recombinant mouse-derived IFN-beta protein, expressed by HEK293 , with tag free.
  • HY-P78141
    IFNAR1 Protein, Human (Biotinylated, HEK293, His-Avi)

    AVP; IFN-alpha/beta R1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-R-1; CRF2-1; IFRC ; IFN-alpha/β R1

    		Human HEK293
    IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2). Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2. IFNAR1 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human IFNAR1 (K28-K436) with C-terminal His and Avi tag, which is produced in HEK293 cells.
  • HY-P73128
    IFN-beta Protein, Human (CHO)

    Interferon beta; IFN-beta; IFNB1; IFB; IFNB

    		Human CHO
    IFN-beta is a secretory cytokine produced by cells under viral infection or nucleic acid stimulation. IFNβ binds to cell surface heterodimeric receptors (IFNAR1/IFNAR2), activates the JAK-STAT signaling pathway, and induces the expression of interferon-stimulated genes (ISGs) (such as PKR, 2'5'-OAS). IFN-beta inhibits viral proliferation, regulates immune responses (such as inhibiting Th1 cell polarization, reducing pro-inflammatory cytokine secretion), inhibits the proliferation of vascular smooth muscle cells and tumor cells. IFN-beta has anti-atherosclerotic and vascular remodeling effects. IFN-beta Protein, Human (CHO) is a recombinant interferon-beta protein (CHO), expressed by CHO, without a tag.
  • HY-P7024
    IFN-beta Protein, Human (HEK293)

    rHuIFN-β; IFNB

    		Human HEK293
    IFN-beta Protein, Human (HEK293) is a cytokine with immunomodulatory properties.IFN-beta Protein, Human (HEK293) can be used for the study of severe COVID-19 (coronavirus disease), it reduce viral load and improve lung pathology in a marmoset model.
  • HY-P70241
    IFN-alpha 1/IFNA13 Protein, Human (HEK293, His)

    rHuInterferon alpha-1, His; Interferon alpha-1/13; IFN-alpha-1/13; Interferon alpha-D; LeIF D; IFNA1; IFNA13

    		Human HEK293
    IFN-alpha 1 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1/IFNA13 Protein, Human (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag.
  • HY-P70610G
    GMP IFN-gamma Protein, Human (HEK293)

    Interferon Gamma; IFN-Gamma; Immune Interferon; IFNG

    		Human HEK293
    IFN-gamma Protein is a cytokine belonging to the interferon family, secreted by activated immune cells such as T cells and NK cells. IFN-gamma Protein plays a key role in the immune system, exerting activities including regulating immune responses, antiviral effects, and antitumor effects. GMP IFN-gamma Protein, Human (HEK293) is a recombinant GMP-grade IFN-gamma protein expressed by HEK293, untagged but glycosylated.
  • HY-P72796
    IFN-alpha 1b/IFNA13 Protein, Human

    Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1; IFNA13

    		Human E. coli
    IFN-alpha 1/13 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1b/IFNA13 Protein, Human contains 166 a.a. (C24-D189, A137V), produced in E. coli cells with tag free.
  • HY-P73131
    IFN-beta Protein, Mouse (HEK293, Fc)

    Interferon beta; IFN-beta; IFNB1; IFB; IFNB

    		Mouse HEK293
    IFN-β protein is a type I interferon that plays a key role in the innate immune response by binding to IFNAR2 and IFNAR1 receptors and activating Jak-STAT signaling. This results in transcriptional regulation of interferon-regulated genes, affecting antiviral proteins, cell proliferation regulators, and immunomodulatory proteins. IFN-beta Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IFN-beta protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P73202
    IFN-lambda 1/IL-29 Protein, Human (HEK293)

    IFN-λ1/IL-29; IL-29; IFN-lambda-1; Cytokine Zcyto21; Interleukin-29

    		Human HEK293
    IFN-lambda 1 (IL-29) is a member of the Type-III interferon family. IFN-lambda 1 signals through a heterodimeric receptor complex comprising IFNλ receptor 1 (IFNLR1) and IL-10 receptor subunit-β (IL-10RB). When IFN-lambda 1 binds with the receptor complex, Jak1 and Tyk2 will be activated, and leads to subsequent tyrosine phosphorylation of the IFN-λR1, and activation of STAT1 and STAT2. IFN-lambda 1 modulates immunity in infections and autoimmune diseases. IFN-lambda 1/IL-29 Protein, Human (HEK293) is a recombinant human IFN-lambda 1 (G20-T200) without any tag, which is produced in HEK293 cell.
  • HY-P73252
    IFN-gamma Protein, Mouse (HEK293, Fc)

    IFG; IFI; IFNG; IFN-gamma; Immune interferon; Interferon gamma

    		Mouse HEK293
    IFN-gamma is a type II interferon family cytokine that participates in antiviral, antibacterial, and antitumor responses. IFN-gamma Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IFN-gamma protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P73127
    IFNAR1 Protein, Mouse (HEK293, His)

    Interferon alpha/beta receptor 1; IFN-alpha/beta R1; Ifnar1; Ifar; Ifnar

    		Mouse HEK293
    IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2). Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2. IFNAR1 Protein, Mouse (HEK293, His) is a recombinant mouse IFNAR1 (M1-T429) with C-terminal His tag, which is produced in HEK293 cells.
  • HY-P73129
    IFN-beta Protein, Human (HEK293, Fc)

    Interferon beta; IFN-beta; IFNB1; IFB; IFNB

    		Human HEK293
    IFN-β (interferon-β) is a key type I interferon cytokine that coordinates the innate immune response to infection, tumors, and inflammation. IFN-β binds to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptors, activates Jak-STAT signaling, and modulates interferon-regulated genes. IFN-beta Protein, Human (HEK293, Fc) is the recombinant human-derived IFN-beta protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P74860
    IFN-alpha/beta R2 Protein, Human (HEK293, hFc)

    Interferon alpha/beta receptor 2; IFN-R-2; Interferon alpha binding protein; IFNAR2; IFNABR; IFNARB

    		Human HEK293
    IFN-alpha/beta R2, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFN-alpha/beta R2 forms the heterodimeric receptor with IFNAR1, and binds to type I IFNs. IFN-alpha/beta R2 also interacts with JAK1 and leads to tyrosine phosphorylation of the IFNARs and STAT proteins. Upon activation by these IFNs, IFNAR1 and IFN-alpha/beta R2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2. IFN-alpha/beta R2 Protein, Human (HEK293, hFc) is a recombinant human IFN-alpha/beta R2 (I27-K243) with C-terminal hFc tag, which is produced in HEK293 cells.
  • HY-P74866
    IFN-alpha 1/IFNA1 Protein, Mouse (P.pastoris, His)

    IFNA1; IFNalpha 1; IFN-alpha 1

    		Mouse P. pastoris
    IFN-alpha 1 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1/IFNA1 Protein, Mouse (P.pastoris, His) is produced in P.pastoris yeast cells with a C-Terminal His-tag.
Cat. No. Product Name Effect Purity