1. Signaling Pathways
  2. Epigenetics
  3. METTL3

METTL3

Methyltransferase-like 3

Methyltransferase-like 3 (METTL3) is an enzyme that functions as a key methyltransferase in the process of N6-methyladenosine (m6A) RNA methylation. METTL3 contains a catalytic domain that is responsible for the transfer of methyl groups to adenosine residues in RNA. METTL3 usually forms a complex with METTL14 and other proteins to enhance its catalytic activity and substrate specificity. The m6A modification mediated by METTL3 plays crucial roles in various biological processes, including RNA splicing, stability, translation efficiency and degradation. METTL3 is involved in the regulation of gene expression and has a significant impact on cell differentiation, development and disease occurrence. Dysregulation of METTL3 has been implicated in many human diseases, especially in the occurrence and development of various cancers[1][2].

METTL3 Related Products (22):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-134836
    STM2457
    Inhibitor 99.86%
    STM2457 is a first-in-class, highly potent, selective and orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be used for the research of acute myeloid leukaemia (AML).
    STM2457
  • HY-156677
    STC-15
    Inhibitor 99.90%
    STC-15 is an orally active RNA methyltransferase METTL3 inhibitor with the activity of activating anti-tumor immunity and reshaping the tumor microenvironment. STC-15 inhibits tumor growth by activating anti-cancer immune responses associated with increased interferon signaling and synergizes with T-cell checkpoint blockade. STC-15 can be used in the study of proliferative diseases such as cancer and autoimmune diseases.
    STC-15
  • HY-115717
    UZH2
    Inhibitor 98.73%
    UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM.
    UZH2
  • HY-162080
    METTL1-WDR4-IN-1
    Inhibitor 98.87%
    METTL1-WDR4-IN-1 (1) is a METTL1-WDR4 inhibitor, with an IC50 of 144 μM.
    METTL1-WDR4-IN-1
  • HY-160415A
    WD6305 TFA
    Inhibitor 99.81%
    WD6305 TFA is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 TFA has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 TFA inhibits m6A modification and proliferation of AML cells, and induces apoptosis. WD6305 TFA has antitumor activity.(Pink: UZH2 (HY-115717); Black: Linker; Blue: VHL ligand (HY-150803))
    WD6305 TFA
  • HY-W037893
    METTL3 activator-1
    Activator 99.38%
    METTL3 activator-1 (2-Piperazinecarboxylic acid methyl ester dihydrochloride) is a Mettl3 activator that can promote the expression of Mettl3. METTL3 activator-1 can be used for the study of liver fibrosis.
    METTL3 activator-1
  • HY-P10387A
    RSM3 TFA
    Inhibitor 98.83%
    RSM3 TFA, a stapled peptide, is a METTL3-METTL14 inhibitor with an Kd of 3.10 μM. RSM3 TFA inhibits tumor growth while induces cell apoptosis. RSM3 TFA can be used for study of cancer.
    RSM3 TFA
  • HY-168878
    EP652
    Inhibitor
    EP652 (compound 56) potently inhibits the enzymatic activity of METTL3, with the IC50s of 2 nM, < 10 nM anf 37 nM in SPA, intracellular and ATPlite assay, respectively. EP652 plays an important role in liquid and solid tumors research.
    EP652
  • HY-153625
    STM2120
    Inhibitor 99.92%
    STM2120 is a METTL3-METTL14 inhibitor with an IC50 of 64.5 μM.
    STM2120
  • HY-158403
    METTL3-IN-7
    Inhibitor
    METTL3-IN-7 (F039-0002) is a potent METTL3 inhibitor. METTL3-IN-7 strongly ameliorates dextran sodium sulfate (DSS)-induced colitis. METTL3-IN-7 can be used Inflammatory bowel disease (IBD) research.
    METTL3-IN-7
  • HY-134673B
    UZH1b
    Inhibitor 99.75%
    UZH1b is an enantiomer of UZH1a (a METTL3 inhibitor). UZH1b is essentially inactive for METTL3 (IC50=28 µM).
    UZH1b
  • HY-159604
    METTL3-IN-9
    Inhibitor
    METTL3-IN-9 (compound C3) is an inhibitor of methyltransferase-like METTL3, an RNA methyltransferase that catalyzes the N6-methyladenosine (m6A) modification of mRNA in eukaryotic cells.
    METTL3-IN-9
  • HY-148467
    METTL3-IN-1
    Inhibitor
    METTL3-IN-1 (compound 23) is a polyheterocyclic compound, acts as METTL3 inhibitor.
    METTL3-IN-1
  • HY-148468
    METTL3-IN-2
    Inhibitor
    METTL3-IN-2 (compound 28) is a METTL3 inhibitor with an IC50 value of 6.1 nM. METTL3-IN-2 inhibits cell proliferation of Caov3 cancer cells.
    METTL3-IN-2
  • HY-148469
    METTL3-IN-3
    Inhibitor
    METTL3-IN-3 (compound 11) is a polyheterocyclic compound, acts as METTL3 inhibitor.
    METTL3-IN-3
  • HY-P10387
    RSM3
    Inhibitor
    RSM3, a stapled peptide, is a METTL3-METTL14 inhibitor with an Kd of 3.10 μM. RSM3 inhibits tumor growth while induces cell apoptosis. RSM3 can be used for study of cancer.
    RSM3
  • HY-158404
    METTL3-IN-8
    Inhibitor
    METTL3-IN-8 (7460-0250) is a potent METTL3 inhibitor. METTL3-IN-8 strongly ameliorates DSS-induced colitis. METTL3-IN-8 can be used Inflammatory bowel disease (IBD) research.
    METTL3-IN-8
  • HY-156759
    METTL3-IN-5
    Inhibitor
    METTL3-IN-5 (Compound 13) is a METTL3 inhibitor. METTL3-IN-5 inhibits MOLM-13 growth with an IC50 less than 2 μM. METTL3-IN-5 has weak hERG inhibitory activity (IC50 >30 μM). METTL3-IN-5 can be used for AML research.
    METTL3-IN-5
  • HY-154997
    7OQL
    Inhibitor
    7OQL (compound 54) is a selective METTL3 inhibitor (IC50=0.054 µM). 7OQL has the potential to be used in the study of cancer.
    7OQL
  • HY-W125425
    Methyl piperazine-2-carboxylate
    Activator
    Methyl piperazine-2-carboxylate (compound 4) is a potent METTL3/METTL14/WTAP activator. Methyl piperazine-2-carboxylate increases HIV-1 p24 virion production. Methyl piperazine-2-carboxylate increases the N6-adenosine methylation level in the viral RNA genome.
    Methyl piperazine-2-carboxylate