Fragment Libraries

Fragment-based drug discovery (FBDD) is a powerful method to develop potent small-molecule compounds starting from fragments binding weakly to targets. FBDD starts by screening libraries of low-molecular weight compounds (fragments) against the target of interest to identify ‘‘hits.’’ The identified hit is then grown into drug-like molecules through different strategies. Although FBDD cannot replace high-throughput screening (HTS) campaigns in drug discovery, it has some attractive advantages such as saving experimental cost, offering diverse hits, and exhibiting multiple ways to develop novel compounds.

Fragment Libraries( 5 )

Cysteine Targeted Covalent Fragment Library

Compound library containing fragments with various warheads targeting cysteine residue.

3,358compounds HY-L154
F-Fragments Library

Unique F (fluorine)-containing compounds developed for fragment-based drug discovery.

5,023compounds HY-L152
Drug Fragment Library

A collection contains 1,000 drug fragments derived from 2,946 FDA-approved drug molecules.

1,000compounds HY-L904
Fragment Library

Unique compounds developed for fragment-based drug discovery.

22,824compounds HY-L032
3D Diverse Fragment Library

Unique 3D diversity fragment library: a new opportunity for fragment-based drug discovery (FBDD).

5,400compounds HY-L903

Compound
Screening Libraries

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