2. Recombinant Proteins
  3. Viral Proteins
  4. HPV Proteins

HPV Proteins

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Human papillomavirus (HPV) is an infectious human virus of the skin. As most papillomaviruses do, HPV can cause papillomas, or skin lesions. low-risk HPV are much more common than high-risk HPV among humans and often do not cause any symptoms. In fact, only 18 types of HPV pose a cancer risk, mostly for anogenital cancers. Papillomaviruses are small, non-enveloped, icosahedral DNA viruses that have a diameter of 52–55 nm. The viral particles consist of a single double-stranded, circular DNA genome of about 8000 bp that contain approximately eight ORFs. The ORF can be divided into three functional parts: the early (E) region that encodes proteins (E1–E7) necessary for viral replication; the late (L) region that encodes the structural proteins (L1–L2) that are required for virion assembly; and a largely non-coding part that is referred to as the long control region (LCR), which contains cis elements that are necessary for the replication and transcription of viral DNA. The viral E proteins are transcribed from the early promoter (e.g. P97 in HPV 31) whereas the L proteins are transcribed principally from the late promoter (P742 in HPV 31).

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72260
    Protein E6, HPV16 (His)

    E6; Protein E6

    		Virus E. coli
    Protein E6 is one of three cancer proteins encoded by human papillomavirus (HPV). The binding of Protein E6 to ubiquitin protein ligase can inhibit the expression of p53. Protein E6 suppresses the immune response through the JAK-STAT signaling pathway. Protein E6 can promote cell proliferation and inhibit cell apoptosis. Protein E6, HPV16 (His) is the recombinant Virus-derived protein E6, HPV16, expressed by E. coli , with N-6*His labeled tag.
  • HY-P72259
    Protein E7, HPV16 (His)

    E7; Protein E7

    		Virus E. coli
    HPV protein E7 can induce dormant cells to enter the cell cycle and promote the efficient use of cellular DNA replication mechanisms for viral genome replication. Through translational and transactivation activities, E7 disrupts the RB1-E2F1 complex and activates E2F1-regulated S-phase genes. Protein E7, HPV16 (His) is the recombinant Virus-derived protein E7, HPV, expressed by E. coli , with N-6*His labeled tag.
  • HY-P700389
    Protein E7, HPV (N-His, C-His)

    Protein E7

    		Virus E. coli
    Protein E7, HPV, crucially induces quiescent cells to enter the cell cycle, facilitating efficient utilization of cellular DNA replicating machinery for viral genome replication. With transforming and trans-activating activities, E7 disrupts the RB1-E2F1 complex, activating E2F1-regulated S-phase genes. It interferes with host histone deacetylation by HDAC1 and HDAC2, inhibiting antiviral functions of interferon alpha. E7's interaction with host TMEM173/STING hinders sensing cytosolic DNA, repressing type I interferon production. Forming homodimers and homooligomers, E7 associates with RB1, disrupting its activity, and with EP300 to repress transcriptional activity. Complex formation with CHD4 and HDAC1 alters host histone deacetylation, while the interaction with protein E2 inhibits E7 oncogenic activity. E7's multifaceted actions underscore its pivotal role in HPV-associated cellular processes and intricate modulation of host cell functions. Protein E7, HPV (N-His, C-His) is the recombinant Virus-derived protein E7, HPV, expressed by E. coli, with N-6*His, C-6*His labeled tag. The total length of Protein E7, HPV (N-His, C-His) is 98 a.a., with molecular weight of 16.3 kDa.
Cat. No. Product Name Effect Purity