2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. 15-PGDH

15-PGDH

15-Hydroxyprostaglandin dehydrogenase

15-PGDH

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15-PGDH (15-Hydroxyprostaglandin dehydrogenase) is a tumor suppressor in breast, colon, liver, lung, and pancreas since decreased expression of this enzyme is associated with increased tumorigenesis. 15-PGDH metabolizes intracellular PGE2 so that this ligand is unable to bind EP receptors, which results in suppression of PGE2 signaling.

The tumor suppressor 15-PGDH is the key enzyme in prostaglandin E2 catabolism and is down-regulated in colorectal cancer (CRC) tissue. Canonical Wnt signaling is frequently elevated in colon cancers and has been shown to down-regulate 15-PGDH expression.

Inhibition of 15-PGDH, a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice. 15-PGDH acts in vivo as a negative regulator of prostaglandin levels and activity, provides a candidate target.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16968
    SW033291
    		Inhibitor 99.68%
    SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration.
    SW033291
  • HY-151807
    15-PGDH-IN-1
    		Inhibitor 99.70%
    15-PGDH-IN-1 is a potent and orally active 15-PGDH inhibitior. 15-PGDH-IN-1 has inhibition activity against recombinant human 15-PGDH with an IC50 value of 3 nM. 15-PGDH-IN-1 can be used for the research of tissue repair and regeneration.
    15-PGDH-IN-1
  • HY-123548
    ML148
    		Inhibitor 99.77%
    ML148 is a potent and selective 15-PGDH inhibitor with an IC50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways.
    ML148
  • HY-124230
    15-PGDH-IN-3
    		Inhibitor
    15-PGDH-IN-3 (Compound 61) is a selective competitive inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH).
    15-PGDH-IN-3
  • HY-117723
    MF-PGDH-008
    		Inhibitor
    MF-PGDH-008 serves as an inhibitor of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.
    MF-PGDH-008
  • HY-174990
    HW201877
    		Inhibitor
    HW201877 is a potent and orally active 15-prostaglandin dehydrogenase (15-PGDH) inhibitor with an IC50 of 3.6 nM. HW201877 demonstrates robust cellular efficacy in elevating PGE2 levels in A549 cells and exhibits remarkable efficacy in animal models of tissue injury and fibrosis. HW201877 can be used for the study of inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF) and Crohn’s disease (CD).
    HW201877
  • HY-116096
    15-epi-PGE1
    		Inhibitor
    15-epi-PGE1 (15R-Prostaglandin E1; 15-Epiprostaglandin E1) is a stereoisomer of PGE1 (HY-B0131) but with less biological activity. 15-epi-PGE1 is a non-competitive inhibitor for human placental 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) with an IC50 of 170 μM.
    15-epi-PGE1
  • HY-116198
    15-PGDH-IN-2
    		Inhibitor
    15-PGDH-IN-2 (Compound 2) is a 15-PGDH inhibitor with an IC50 value of 0.274 nM. 15-PGDH-IN-2 can be used in research on hair loss, bone formation, gastric ulcer healing, and dermal wound healing.
    15-PGDH-IN-2
  • HY-P10457
    15-Hydroxy prostaglandin dehydrogenase blocking peptide
    		Inhibitor
    5-Hydroxy prostaglandin dehydrogenase blocking peptide (15-PGDH (92-105)) is a blocking peptide that corresponds to the amino acids (AGVNNEKNWEKTLQ) located at positions 92-105 of the 15-hydroxy prostaglandin dehydrogenase (15-PGDH) sequence. 5-Hydroxy prostaglandin dehydrogenase blocking peptide can block the formation of protein-antibody complexes during immunohistochemical analysis of 15-PGDH.
    15-Hydroxy prostaglandin dehydrogenase blocking peptide
Cat. No. Product Name / Synonyms Application Reactivity