2. One-stop Drug Screening
  3. Screening Libraries
  4. 5K Scaffold Library
5K Scaffold Library

Cat. No.: HY-L902

MCE 5K Scaffold Library consists of 5,000 lead-like compounds. Each compound represents one unique scaffold. All compounds are compatible with Lipinski’s rule (Rule of 5) with multiple characteristics such as calculated good solubility (-3.2 < logP < 5), oral bioavailability (RotB <= 10), drug transportability (PSA < 120). Compounds contained within the library have been screened to remove any inappropriate chemical structures, avoiding “false hits”. The sufficient diverse of compound structure makes this library a powerful tool for drug screening.

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Description & Advantages

•    Maximum structural diversity.

•    Each compound represents one unique scaffold. 5,000 unique scaffods (Bemis-Murcko) totally.

•   Compatible with Lipinski’s rule (Rule of 5), with multiple characteristics such as calculated good solubility (-3.2 < logP < 5), oral bioavailability (RotB <= 10), drug transportability (PSA < 120), MW between 300 to 500, number of Hydrogen Bond Donor (HBD) ≤ 5, number of Hydrogen Bond Acceptor (HBA) ≤ 10.

•   Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.

•   All 5,000 compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.

•   NMR and HPLC validated to ensure high purity and quality.

Product Details

•    Maximum structural diversity.

•    Each compound represents one unique scaffold. 5,000 unique scaffods (Bemis-Murcko) totally.

•   Compatible with Lipinski’s rule (Rule of 5), with multiple characteristics such as calculated good solubility (-3.2 < logP < 5), oral bioavailability (RotB <= 10), drug transportability (PSA < 120), MW between 300 to 500, number of Hydrogen Bond Donor (HBD) ≤ 5, number of Hydrogen Bond Acceptor (HBA) ≤ 10.

•   Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.

•   All 5,000 compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.

•   NMR and HPLC validated to ensure high purity and quality.

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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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