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Hepatocyte growth factor (HGF, also known as Scatter Factor) is among a group of factors possessing angiogenic ability. It belongs to the soluble cytokine family and is also a member of the plasminogen-related growth factor family. HGF is secreted by mesenchymal stem cells，and regulates cell growth, cell motility and morphogenesis of epithelial cells, endothelial cells, and haematopoietic stem cells, through its receptor, c-Met. Under normal conditions, HGF/c-Met axis plays an important role in normal biological functions in organism. However, in cancer cells, abnormal activation of HGF/c-Met axis promotes tumor development and progression by stimulating the PI3K/AKT, Ras/MAPK, JAK/STAT, SRC, Wnt/β-catenin, and other signaling pathways.
Hepatocyte growth factor; F-TCF; Hepatopoeitin-A; HGF; HGFB; HPTA; SF
Mouse
HEK293
HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth and acts as a hepatotrophic factor for various tissues. As an activating ligand for MET receptor tyrosine kinase, HGF binds and promotes dimerization, activating MAPK signaling through TMPRSS13 cleavage. Structurally, HGF comprises alpha and beta chains connected by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. HGF Protein, Mouse (HEK293) is the recombinant mouse-derived HGF protein, expressed by HEK293 , with tag free.
HGF Protein is a hepatocyte growth factor involved in signaling pathways including MET and MAPK. The HGF Protein consists of 728 amino acids, with an alpha chain containing an n-terminal domain four kringle domains, and a β serine protease domain. HGF Protein, Human (HEK293, His) is the recombinant human-derived HGF protein, expressed by HEK293 , with C-His labeled tag. The total length of HGF Protein, Human (HEK293, His) is 697 a.a., with molecular weight of 32-37 & 52-70 & 80-100 kDa, respectively.
HGF receptor; SF receptor; Tyrosine-protein kinase Met
Human
HEK293
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, hFc) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag.
Hepatocyte growth factor receptor; HGF receptor; SF receptor; MET
Human
Sf9 insect cells
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (sf9, His-GST) is the recombinant human-derived HGFR protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
MET; oncogene MET; HGF R; HGF/SF receptor; AUTS9; cMET; Met (c-Met); RCCP2; SF receptor
Human
HEK293
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, His-Avi) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
Hepatocyte growth factor receptor; HGF receptor; SF receptor; MET
Canine
HEK293
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Canine (HEK293, His) is the recombinant canine-derived HGFR protein, expressed by HEK293 , with N-His labeled tag. The total length of HGFR Protein, Canine (HEK293, His) is 911 a.a., with molecular weight of ~35-43 kDa & 80-100 kDa, respectively.
Hepatocyte growth factor receptor; HGF receptor; SF receptor; MET
Mouse
HEK293
HGFR Protein, a receptor tyrosine kinase, transduces signals by binding hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding, HGFR undergoes autophosphorylation, creating docking sites for downstream molecules like PI3K, PLCG1, SRC, GRB2, STAT3, or GAB1, activating RAS-ERK, PI3K-AKT, and PLCgamma-PKC cascades. HGFR Protein, Mouse (HEK293, His) is the recombinant mouse-derived HGFR protein, expressed by HEK293, with C-His labeled tag. The total length of HGFR Protein, Mouse (HEK293, His) is 905 a.a., with molecular weight of ~34-42 kDa & 79-90 kDa, respectively.
HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth and acts as a hepatotrophic factor for various tissues. As an activating ligand for MET receptor tyrosine kinase, HGF binds and promotes dimerization, activating MAPK signaling through TMPRSS13 cleavage. Structurally, HGF comprises alpha and beta chains connected by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. HGF Protein, Mouse (HEK293, His) is the recombinant mouse-derived HGF protein, expressed by HEK293 , with C-6*His labeled tag.
Hepatocyte growth factor; F-TCF; Hepatopoeitin-A; HGF; HGFB; HPTA; SF
Rat
HEK293
The HGF gene encodes hepatocyte growth factor (HGF), a protein involved in organ regeneration, angiogenesis, and myelination. It is located in the extracellular space and serves as a biomarker for cholangiocarcinoma. Implicated in various diseases, HGF plays a crucial role in physiological and pathological conditions. It shows biased expression in the liver (RPKM 137.5), lung (RPKM 132.1), and other tissues. HGF Protein, Rat (HEK293) is the recombinant rat-derived HGF protein, expressed by HEK293 , with tag free.
Hepatocyte growth factor; F-TCF; Hepatopoeitin-A; HGF; HGFB; HPTA; SF
Cynomolgus
HEK293
HGF Protein, a potent mitogen, stimulates mature hepatocyte growth and exhibits hepatotrophic properties for various tissues. It acts as an activating ligand for the receptor tyrosine kinase MET, promoting dimerization upon binding. Structurally, HGF Protein comprises alpha and beta chains linked by a disulfide bond. Additionally, it interacts with SRPX2, enhancing HGF's mitogenic activity. HGF Protein, Cynomolgus (HEK293) is the recombinant cynomolgus-derived HGF protein, expressed by HEK293 , with tag free.
Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; MET
Human
HEK293
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, Fc) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag.
Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; MET
Human
HEK293
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, His) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-6*His labeled tag.
Hepatocyte growth factor receptor; HGF receptor; SF receptor; MET
Rhesus Macaque; Cynomolgus
HEK293
HGFR Protein, a receptor tyrosine kinase, transduces signals by binding hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding, HGFR undergoes autophosphorylation, creating docking sites for downstream molecules like PI3K, PLCG1, SRC, GRB2, STAT3, or GAB1, activating RAS-ERK, PI3K-AKT, and PLCgamma-PKC cascades. HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293) is the recombinant Rhesus Macaque, cynomolgus-derived HGFR protein, expressed by HEK293 , with tag free.
Hepatocyte growth factor receptor; HGF receptor; SF receptor; MET
Rat
HEK293
HGFR Protein is a receptor tyrosine kinase that acts as a signal transducer of the extracellular matrix by binding to hepatocyte growth factor /HGF ligands. HGFR Protein participate in the activation of RAS-ERK, PI3 kinase-AKT, and PLCgamma-PKC signaling pathways. HGFR Protein is essential for embryonic development, organogenesis, and wound healing. HGFR Protein, Rat (HEK293, Fc) is the recombinant rat-derived HGFR protein, expressed by HEK293, with C-hFc labeled tag. The total length of HGFR Protein, Rat (HEK293, Fc) is 908 a.a., with molecular weight of ~97 & 39 kDa, respectively.
HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth, acting as a hepatotrophic factor for various tissues.It activates MAPK signaling through TMPRSS13 cleavage and activates MET receptor tyrosine kinase by promoting its dimerization.Structurally, HGF comprises alpha and beta chains connected by a disulfide bond.Interaction with SRPX2 enhances its mitogenic activity.HGF Protein, Rat (GST) is the recombinant rat-derived HGF protein, expressed by E.coli , with N-GST labeled tag.
Hepatocyte growth factor; F-TCF; Hepatopoeitin-A; HGF; HGFB; HPTA; SF
Canine
HEK293
HGF protein is a potent hepatocyte mitogen that stimulates mature hepatocyte proliferation and exhibits multiple growth factor properties in different tissues. As a ligand of MET receptor tyrosine kinase, HGF initiates downstream signaling cascades upon binding, activating MAPK signaling after TMPRSS13 cleavage. HGF Protein, Canine (HEK293) is the recombinant canine-derived HGF protein, expressed by HEK293 , with tag free.
Hepatocyte growth factor receptor; HGF receptor; SF receptor; MET
Mouse
HEK293
The HGFR protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix by binding to hepatocyte growth factor/HGF ligand. This interaction regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag.
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. FITC-Labeled HGFR Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled HGFR protein, expressed by HEK293 , with His labeled tag. The total length of FITC-Labeled HGFR Protein, Human (HEK293, His) is 908 a.a., with molecular weight of 30-40 kDa & 90-100 kDa & 150 kDa, respectively.
Hepatocyte growth factor receptor; Proto-oncogene c-Met; SF receptor; Tyrosine-protein kinase Met; MET
Human
HEK293
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.
