2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Kinesin

Kinesin

Kinesin

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Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins also can be classified into three groups based on the position of their motor domains: N-terminal, C-terminal and internal kinesins. Conventional kinesin operates as a dimer, walking in a co-ordinated, hand-over-hand fashion along a microtubule protofilament.

Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.

Kinesin Isoform Specific Products:

Kinesin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-132840
    Sovilnesib
    		Inhibitor 99.89%
    Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC50 value of 0.071 μM. Sovilnesib can be used for the research of cancer.
    Sovilnesib
  • HY-50759
    Ispinesib
    		Inhibitor 99.62%
    Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
    Ispinesib
  • HY-101071A
    Monastrol
    		Inhibitor 99.89%
    Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
    Monastrol
  • HY-10299
    GSK-923295
    		Inhibitor 99.82%
    GSK-923295 is a special, allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively.
    GSK-923295
  • HY-15187
    Filanesib
    		Inhibitor 98.23%
    Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity.
    Filanesib
  • HY-115570A
    (Z/E)-GW406108X
    		Inhibitor
    (Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM.
    (Z/E)-GW406108X
  • HY-162937
    KIF18A-IN-13
    		Inhibitor
    KIF18A-IN-13 (Compound 16) is an effective and orally active inhibitor of KIF18A with anticancer activity in vivo. KIF18A-IN-13 can be utilized for research in ovarian cancer.
    KIF18A-IN-13
  • HY-164978
    KIF18A-IN-14
    		Inhibitor
    KIF18A-IN-14 (Compound Example 81) is a KIF18A inhibitor. KIF18A-IN-14 is available in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit OVCAR-3 cells viability with IC50s of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be used in tumor (e.g. colon, breast, lung) studies.
    KIF18A-IN-14
  • HY-12241
    AZ82
    		Inhibitor 99.31%
    AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1.
    AZ82
  • HY-W011102
    S-Trityl-L-cysteine
    		Inhibitor 99.10%
    S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities.
    S-Trityl-L-cysteine
  • HY-12069
    SB-743921 hydrochloride
    		Inhibitor 99.87%
    SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM.
    SB-743921 hydrochloride
  • HY-14846
    Litronesib
    		Inhibitor 99.59%
    Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity.
    Litronesib
  • HY-101770
    BTB-1
    		Inhibitor 99.75%
    BTB-1 is a potent, selective and reversible mitotic motor protein Kif18A inhibitor with an IC50 of 1.69 μM.
    BTB-1
  • HY-101298
    Paprotrain
    		Inhibitor 99.87%
    Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.
    Paprotrain
  • HY-19944
    Dimethylenastron
    		Inhibitor 98.07%
    Dimethylenastron is a potent kinesin Eg5 inhibitor, with an IC50 of 200 nM.
    Dimethylenastron
  • HY-153065
    KIF18A-IN-6
    		Inhibitor 98.56%
    KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor with an IC50 of 0.016 μM against KIF18A microtubule-dependent ATPase activity.
    KIF18A-IN-6
  • HY-15000
    EMD534085
    		Inhibitor 99.55%
    EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.
    EMD534085
  • HY-144894
    AM-5308
    		Inhibitor 99.26%
    AM-5308 is a potent kinesin KIF18A inhibitor (WO2021211549A1, C13).
    AM-5308
  • HY-15857
    CW-069
    		Inhibitor 99.37%
    CW-069 is an allosteric inhibitor of microtubule motor protein HSET with an IC50 of 75 μM.
    CW-069
  • HY-15948
    Kif15-IN-1
    		Inhibitor 99.39%
    Kif15-IN-1 is an inhibitor of the mitotic Kinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases.
    Kif15-IN-1
Cat. No. Product Name / Synonyms Application Reactivity
Kinesin Isoform Comparison

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