2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Protein Kinase Inhibitor Peptide (PKI)

Protein Kinase Inhibitor Peptide (PKI)

Recombinant Protein Expression Service

Protein Kinase Inhibitor Peptide (PKI)

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The protein kinase inhibitors (PKIs) are a family of proteins which act as pseudosubstrates for PKA by binding to the PKA catalytic subunits, blocking its kinase activity, modulating the extent, and duration of PKA-mediated signaling events. PKI family includes three genes encoding small, heat-stable inhibitors, PKIα, PKIβ, and PKIγ. Each PKI isoform contains a PKA inhibitory domain and a nuclear export domain, enabling PKI to both inhibit PKA and remove it from the nucleus. PKIα is highly expressed in skeletal muscle, heart, cerebral cortex, and cerebellum, whereas PKIβ is most highly expressed in testis, with a small amount of expression in brain and little to none elsewhere. PKIγ mRNA is widely expressed and found most highly expressed in heart and testis. Some tissues possess multiple isoforms of PKI, in which case the expression pattern is cell specific. For example, PKIα is localized to the Sertoli cells and PKIβ is localized to the germ cells in the testis.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P71209
    PKI-beta Protein, Human (His)

    cAMP-Dependent Protein Kinase Inhibitor Beta; PKI-beta; PKIB; PRKACN2

    		Human E. coli
    The PKI-β protein emerged as an extremely potent competitive inhibitor of cAMP-dependent protein kinase activity. This protein operates at the molecular level, binding to the catalytic subunit of the enzyme after cAMP induces dissociation of its regulatory chain. PKI-beta Protein, Human (His) is the recombinant human-derived PKI-beta protein, expressed by E. coli , with N-6*His labeled tag.
  • HY-P74491
    TRIB3 Protein, Human (sf9, GST)

    Tribbles homolog 3; TRB-3; SINK; C20orf97; NIPK; SKIP3

    		Human Sf9 insect cells
    TRIB3 protein is an inactive kinase that centrally regulates the integrated stress response (ISR) and inhibits DDIT3/CHOP transcriptional activity. It causes DDIT3/CHOP-dependent cell death during endoplasmic reticulum (ER) stress, particularly in programmed neuronal cell death. TRIB3 Protein, Human (sf9, GST) is the recombinant human-derived TRIB3 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of TRIB3 Protein, Human (sf9, GST) is 358 a.a., with molecular weight of ~65.8 kDa.
  • HY-P74492
    TRIB2 Protein, Human (sf9, His-GST)

    Tribbles homolog 2; TRB-2; TRIB2; TRB2

    		Human Sf9 insect cells
    TRIB2 protein regulates MAP kinase activation by interacting with MAPK kinase, acting as a regulator without intrinsic kinase activity. Emphasizing its role in fine-tuning the MAP kinase signaling pathway. TRIB2 Protein, Human (sf9, His-GST) is the recombinant human-derived TRIB2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag. The total length of TRIB2 Protein, Human (sf9, His-GST) is 343 a.a., with molecular weight of ~66 kDa.
  • HY-P703010
    IRAK3 Protein, Human (sf9, GST)

    Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M (IRAK-M); Inactive IL-1 receptor-associated kinase 3; IRAK3

    		Human Sf9 insect cells
    IRAK3 Protein, Human (sf9, GST) is the recombinant human-derived IRAK3, expressed by Sf9 insect cells , with GST labeled tag. ,
  • HY-P703012
    14-3-3 theta Protein, Mouse (sf9, His)

    14-3-3 protein theta; 14-3-3 protein tau; Ywhaq

    		Mouse Sf9 insect cells
  • HY-P703013
    14-3-3 zeta Protein, Mouse (sf9, His)

    14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1 (KCIP-1); SEZ-2; Ywhaz

    		Mouse Sf9 insect cells
    14-3-3 zeta Protein, Mouse (sf9, His) is the recombinant mouse-derived 14-3-3 zeta, expressed by Sf9 insect cells , with His labeled tag. The total length of 14-3-3 zeta Protein, Mouse (sf9, His) is 245 a.a.,
Cat. No. Product Name Effect Purity