<b>Escherichia coli</b>

By Targets:	Amyloid-β (1) Bacterial (2) Cholinesterase (ChE) (1) Dihydrofolate reductase (DHFR) (1) Fungal (1) Parasite (1) PROTACs (1) Tau Protein (1) Toll-like Receptor (TLR) (1) VEGFR (1)
By Research Areas:	Cancer (2) Infection (2) Inflammation/Immunology (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 170+ Cited Publications LPS, from Escherichia coli (O55:B5)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .

HY-N5102

D-(+)-Fucose	Others	Others
D-(+)-Fucose is a nonmetabolizable analogue of l-arabinose. D-(+)-Fucose prevents growth of Escherichia coli B/r on a mineral salts medium plus l-arabinose by inhibiting induction of the l-arabinose operon . D-fucose is a potent inducer of beta-methylgalactoside permease (MGP) .

HY-149679

PROTAC eDHFR Degrader-2	PROTACs Bacterial	Cancer
PROTAC eDHFR Degrader-2 (compound 7b) is a potent degrader targeting Escherichia coli dihydrofolate reductase (eDHFR), enabling robust degradation of eDHFR-tagged proteins .

HY-150585

BuChE-IN-5	Amyloid-β Cholinesterase (ChE) Tau Protein	Neurological Disease
BuChE-IN-5 (compound 25b) is a potent BuChE inhibitor with an IC₅₀ value of 1.94 μM. BuChE-IN-5 efficiently inhibits aggregation Aβ and tau protein in Escherichia coli. BuChE-IN-5 also has free radical scavenging capacity and antioxidant activity. BuChE-IN-5 can be used for researching Alzheimer’s disease .

HY-143487

Antimalarial agent 12	Parasite	Infection
Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC₅₀=155 nM), 3D7 strain (EC₅₀=136 nM). Antimalarial agent 12 has CC₅₀ values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli .

HY-151458

VEGFR-2/DHFR-IN-1	VEGFR Bacterial Dihydrofolate reductase (DHFR) Fungal	Infection Cancer
VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC₅₀s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC₅₀ values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer .

Cat. No.	Product Name	Type

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 170+ Cited Publications LPS, from Escherichia coli (O55:B5)	Biochemical Assay Reagents
Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .

Lipopolysaccharides, from E. coli O55:B5

170+ Cited Publications

LPS, from Escherichia coli (O55:B5)

Biochemical Assay Reagents

Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 170+ Cited Publications LPS, from Escherichia coli (O55:B5)	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Saccharides	Toll-like Receptor (TLR)
Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells . This product is derived from Escherichia coli O55:B5. Lipopolysaccharides induces secretion of cell migrasome .

HY-N5102

D-(+)-Fucose	Ipomoea muricata Source classification Other Diseases Plants Disease Research Fields Convolvulaceae Saccharides	Others
D-(+)-Fucose is a nonmetabolizable analogue of l-arabinose. D-(+)-Fucose prevents growth of Escherichia coli B/r on a mineral salts medium plus l-arabinose by inhibiting induction of the l-arabinose operon . D-fucose is a potent inducer of beta-methylgalactoside permease (MGP) .

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<b>Escherichia coli</b>

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