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BMY-28090

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16192
    Elsamitrucin

    BMY-28090; SPI-28090; Antibiotic BBM 2478A

    		 Bacterial Infection
    Elsamitrucin, derived from actinomycete fermentation, exhibits potent cytotoxicity against a range of murine and human tumor cell lines in vitro, with IC50 values ranging from <0.02 to 3.25 μg/ml after 72-hour exposures. In vivo studies demonstrated significant antitumor activity in various experimental murine tumor models, including P388 leukemia, L1210 leukemia, B16 melanoma, and M5076 sarcoma, when administered intraperitoneally as a water-insoluble free base or as water-soluble lactate or succinate salts. Elsamitrucin also showed efficacy against human MX-1 mammary tumor and HCT116 colon tumor xenografts, highlighting its broad-spectrum cytotoxicity and potential as an antitumor agent across different tumor types and models .
    Elsamitrucin

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