2. Signaling Pathways
  3. Apoptosis
  4. Transferrin Receptor

Transferrin Receptor

TfR; CD71

 

Transferrin Receptor Related Products (9):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P3267
    Transferrins
    		≥99.0%
    Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrins can bind to and mediate the transport of iron.
    Transferrins
  • HY-NP011
    Human transferrin (suitable for cell culture)
    Human transferrin (suitable for cell culture) is a glycoprotein with a branched sugar chain that mediates the transport of iron from plasma to cells.
    Human transferrin (suitable for cell culture)
  • HY-P2297A
    TfR-T12 TFA
    		99.10%
    TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range.
    TfR-T12 TFA
  • HY-P3267A
    Apo-Transferrin
    		Activator
    Apo-Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin indicates an iron deficient environment, can directly bind to hephaestin, which can convert Fe2+ to Fe3+. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1.
    Apo-Transferrin
  • HY-P99797
    Pabinafusp alfa
    Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice.
    Pabinafusp alfa
  • HY-159569
    TfR-1-IN-1
    		Inhibitor
    TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values ​​of 0.51, 0.46, and 0.48 μM, respectively.
    TfR-1-IN-1
  • HY-P990780
    Zeleciment
    Zeleciment is an anti-TFRC IgG1κ monoclonal antibody.
    Zeleciment
  • HY-P2314
    HAIYPRH hydrochloride
    		99.97%
    HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier.
    HAIYPRH hydrochloride
  • HY-P2297
    TfR-T12
    TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range.
    TfR-T12