AUTOTACs

AUTOphagy-TArgeting Chimeras

AUTOphagy-TArgeting Chimera (AUTOTAC) employs bifunctional molecules composed of target-binding ligands linked to autophagy-targeting ligands. AUTOTACs bind the ZZ domain of the otherwise dormant autophagy receptor p62/Sequestosome-1/SQSTM1, which is activated into oligomeric bodies in complex with targets for their sequestration and degradation.

AUTOTACs Related Products (10):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-161742

Fumagilin-105	2410081-58-0
Fumagilin-105 is an autophagy targeting chimera (AUTOTAC) that induces p62 self-oligomerization with DC₅₀ values of 0.7 μM for MetAP2 in HEK293 cells.

HY-161740

PHTPP-1304	2410081-60-4	99.96%
PHTPP-1304 is a PHTPP-based autophagy targeting chimera (AUTOTAC) that induces p62 self-oligomerization and degradation of estrogen receptor ERβ (DC50:~2 nM, HEK293T). PHTPP-1304 also induces the formation of p62⁺ERβ⁺ puncta that are affected by autophagic flux in a dose-dependent manner.

HY-161739

YOK-1304	2409960-03-6
YOK-1304 is a ligand of p62-ZZ domain. YOK-1304 can activate p62-dependent selective macroautophagy. YOK-1304 can be used for AUTOTAC design.

HY-W489121

YTK-105	774192-20-0	98.81%
YTK-105 is a ligand of p62-ZZ domain. YTK-105 can activate p62-dependent selective macroautophagy. YTK-105 can be used for AUTOTAC design.

HY-161746

Anle138b-F105	2941386-44-1
Anle138b-F105 is an autophagy targeting chimera (AUTOTAC) with DC₅₀ values of 3 nM. Anle138b-F105 targetes tauP301L for lysosomal degradation.

HY-161738

YOK-2204	2409959-99-3
YOK-2204 is a ligand of p62-ZZ domain. YOK-2204 can activate p62-dependent selective macroautophagy. YOK-2204 can be used for AUTOTAC design.

HY-161744

PBA-1106	2410081-55-7
PBA-1106 is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1106 increases the autophagic flux of Ub-conjugated aggregates.

HY-161745

PBA-1105b	2941386-60-1
PBA-1105b is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105b increases the autophagic flux of Ub-conjugated aggregates. PBA-1105b is a drastically longer PEG-based linker than PBA-1105.

HY-161743

PBA-1105	2410081-56-8
PBA-1105 is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 increases the autophagic flux of Ub-conjugated aggregates.

HY-161737

YT-8-8	892572-23-5
YT-8-8 is a ligand of p62-ZZ domain. YT-8-8 can activate p62-dependent selective macroautophagy. YT-8-8 can be used for AUTOTAC design.

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